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MBC in Press, published online ahead of print March 7, 2002
Mol. Biol. Cell 10.1091/mbc.01-09-0455

A more recent version of this article appeared on April 1, 2002
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Submitted on September 17, 2001
Revised on December 4, 2001
Accepted on December 24, 2001

The spindle pole body protein Cdc11p links Sid4p to the fission yeast septation initiation network

Gregory Tomlin1, Jennifer L. Morrell1, and Kathleen L. Gould1*

1 HHMI and Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232

* Corresponding author. E-mail address: kathy.gould{at}mcmail.vanderbilt.edu.

The Schizosaccharomyces pombe septation initiation network (SIN) signals the onset of cell division from the spindle pole body (SPB) and is regulated by the small GTPase Spg1p. The localization of SIN components including Spg1p to the SPB is required for cytokinesis and is dependent on Sid4p, a constitutive resident of SPBs. However, a direct interaction between Sid4p and other members of the SIN has not been detected. To understand how Sid4p is linked to other SIN components, we have begun to characterize a S. pombe homolog of the Saccharomyces cerevisiae SPB protein Nud1p. We have determined that this S. pombe Nud1p homolog corresponds to Cdc11p, a previously uncharacterized SIN element. We report that Cdc11p is present constitutively at SPBs and that its function appears to be required for the localization of all other SIN components to SPBs with the exception of Sid4p. The Cdc11p C-terminus localizes the protein to SPBs in a Sid4p-dependent manner, and we demonstrate a direct Cdc11p-Sid4p interaction. The N-terminus of Cdc11p is required for Spg1p binding to SPBs. Our studies indicate that Cdc11p provides a physical link between Sid4p and the Spg1p signaling pathway.




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