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A more recent version of this article appeared on May 1, 2002
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Submitted on December 21, 2001
Accepted on February 7, 2002
1 Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Queensland, 4072, Australia
2 Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Queensland, 4072, Australia (present address: Institute of Pathology, University of Oslo, The National Hospital, 0027 Oslo, Norway)
3 European Molecular Biology Laboratory, Heidelberg, Germany
* Corresponding author. E-mail address: r.parton{at}imb.uq.edu.au.
Simian Virus 40 (SV40) is a non-enveloped virus which has been shown to pass from surface caveolae to the endoplasmic reticulum (ER) in an apparently novel infectious entry pathway. We now show that the initial entry step is blocked by brefeldin A (BFA) and by incubation at 20 degrees C. Subsequent to the entry step, the virus reaches a domain of the rough ER by an unknown pathway. This intracellular trafficking pathway is also BFA-sensitive. Infection is strongly inhibited by expression of GTP-restricted Arf1 and Sar1 mutants and by microinjection of antibodies to ßCOP. In addition we demonstrate a potent inhibition of SV40 infection by the dipeptide, Cbz-gly-phe-NH2, which also inhibits late events in cholera toxin action. Our results identify novel inhibitors of SV40 infection and show that SV40 requires COPI- and COPII-dependent transport steps for successful infection.
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