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MBC in Press, published online ahead of print April 3, 2002
Mol. Biol. Cell 10.1091/mbc.02-01-0608

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Submitted on January 9, 2002
Revised on February 28, 2002
Accepted on March 8, 2002

A polymer model for large-scale chromatin organization in lower eukaryotes

Joseph Ostashevsky1*

1 Department of Radiation Oncology, SUNY Downstate Medical Center, Box 1212, Brooklyn, NY 11203, USA

* Corresponding author. E-mail address: jostashevsky{at}netmail.hscbklyn.edu.

A quantitative model of large-scale chromatin organization was applied to nuclei of fission yeast S. pombe (meiotic prophase and G2 phase), budding yeast S. cerevisiae (young and senescent cells), Drosophila (embryonic cycles 10 and 14, and polytene tissues) and C. elegans (G1 phase). The model is based on the coil-like behavior of chromosomal fibers, and the tight packing of discrete chromatin domains in a nucleus. Intra-chromosomal domains are formed by chromatin anchoring to nuclear structures (e.g., the nuclear envelope). The observed sizes for confinement of chromatin diffusional motion are similar to the estimated sizes of corresponding domains. The model correctly predicts chromosome configurations (linear, Rabl, loop) and chromosome associations (homologous pairing, centromere and telomere clusters) on the basis of the geometrical constraints imposed by nuclear size and shape. Agreement between the model predictions and literature observations supports the notion that the average linear density of the 30-nm chromatin fiber is ~ 4 nucleosomes per 10 nm contour length.




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