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A more recent version of this article appeared on June 1, 2002
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Submitted on January 8, 2002
Revised on February 26, 2002
Accepted on March 7, 2002
1 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305
2 Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL
3 Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
4 Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305
* Corresponding author. E-mail address: pbrown{at}cmgm.stanford.edu.
* Corresponding author. E-mail address: Botstein{at}genome.stanford.edu.
The genome-wide program of gene expression during the cell division cycle in a human cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of more than 850 genes showed periodic variation during the cell cycle. Hierarchical clustering of the expression patterns revealed co-expressed groups of previously well-characterized genes involved in essential cell cycle processes such as DNA replication, chromosome segregation and cell adhesion along with genes of uncharacterized function. Most of the genes whose expression had previously been reported to correlate with the proliferative state of tumors were found here also to be periodically expressed during the HeLa cell cycle. However, some of the genes periodically expressed in the HeLa cell cycle do not have a consistent correlation with tumor proliferation. Cell cycle regulated transcripts of genes involved in fundamental processes such as DNA replication and chromosome segregation appear to be more highly expressed in proliferative tumors simply because they contain more cycling cells. The data in this report provide a comprehensive catalog of cell cycle regulated genes that can serve as a starting point for functional discovery. The full data set is available at http://genome-www.stanford.edu/Human-CellCycle/HeLa/.
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