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Vol. 10, Issue 1, 47-61, January 1999
and§
Recent evidence suggests that apical and basolateral
endocytic pathways in epithelia converge in an apically located,
pericentriolar endosomal compartment termed the apical recycling
endosome. In this compartment, apically and basolaterally internalized
membrane constituents are thought to be sorted for recycling back to
their site of origin or for transcytosis to the opposite plasma
membrane domain. We report here that in the epithelial cell line
Madin-Darby Canine Kidney (MDCK), antibodies to Rab11a label an
apical pericentriolar endosomal compartment that is dependent on intact
microtubules for its integrity. Furthermore, this compartment is
accessible to a membrane-bound marker (dimeric immunoglobulin A
[IgA]) internalized from either the apical or basolateral pole,
functionally defining it as the apical recycling endosome. We have also
examined the role of a closely related epithelial-specific Rab, Rab25,
in the regulation of membrane recycling and transcytosis in MDCK cells. When cDNA encoding Rab25 was transfected into MDCK cells, the protein
colocalized with Rab11a in subapical vesicles. Rab25 transfection also
altered the distribution of Rab11a, causing the coalescence of
immunoreactivity into multiple denser vesicular structures not
associated with the centrosome. Nevertheless, nocodazole still dispersed these vesicles, and dimeric IgA internalized from either the
apical or basolateral membrane was detected in endosomes labeled with
antibodies to both Rab11a and Rab25. Overexpression of Rab25 decreased
the rate of IgA transcytosis and of apical, but not basolateral,
recycling of internalized ligand. Conversely, expression of the
dominant-negative Rab25T26N did not alter either apical recycling or
transcytosis. These results indicate that both Rab11a and Rab25
associate with the apical recycling system of epithelial cells and
suggest that Rab25 may selectively regulate the apical recycling and/or
transcytotic pathways.
Institute for Molecular Medicine and
Genetics, Departments of Medicine, Surgery, Cellular Biology and
Anatomy, Medical College of Georgia and the Augusta Veterans Affairs
Medical Center, Augusta, Georgia 30912;
*Pediatric Gastroenterology
Unit, Massachusetts General Hospital East, and Program in Biological
and Biomedical Sciences, Harvard University Medical School,
Charlestown, Massachusetts 02129; and
Department of
Anatomy, University of California, San Francisco, California 94143
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 F. Jankovics, R. Sinka, and M. Erdelyi An Interaction Type of Genetic Screen Reveals a Role of the Rab11 Gene in oskar mRNA Localization in the Developing Drosophila melanogaster Oocyte Genetics, July 1, 2001; 158(3): 1177 - 1188. [Abstract] [Full Text] [PDF]
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L. A. Lapierre, R. Kumar, C. M. Hales, J. Navarre, S. G. Bhartur, J. O. Burnette, D. W. Provance Jr., J. A. Mercer, M. Bahler, and J. R. Goldenring Myosin Vb Is Associated with Plasma Membrane Recycling Systems Mol. Biol. Cell, June 1, 2001; 12(6): 1843 - 1857. [Abstract] [Full Text] [PDF]
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 C. T Okamoto and J. G Forte Vesicular trafficking machinery, the actin cytoskeleton, and H+-K+-ATPase recycling in the gastric parietal cell J. Physiol., April 15, 2001; 532(2): 287 - 296. [Abstract] [Full Text] [PDF]
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Y. Takai, T. Sasaki, and T. Matozaki Small GTP-Binding Proteins Physiol Rev, January 1, 2001; 81(1): 153 - 208. [Abstract] [Full Text] [PDF]
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R. Gagescu, N. Demaurex, R. G. Parton, W. Hunziker, L. A. Huber, and J. Gruenberg The Recycling Endosome of Madin-Darby Canine Kidney Cells Is a Mildly Acidic Compartment Rich in Raft Components Mol. Biol. Cell, August 1, 2000; 11(8): 2775 - 2791. [Abstract] [Full Text]
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S.-M. Leung, W. G. Ruiz, and G. Apodaca Sorting of Membrane and Fluid at the Apical Pole of Polarized Madin-Darby Canine Kidney Cells Mol. Biol. Cell, June 1, 2000; 11(6): 2131 - 2150. [Abstract] [Full Text]
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E. Orzech, S. Cohen, A. Weiss, and B. Aroeti Interactions between the Exocytic and Endocytic Pathways in Polarized Madin-Darby Canine Kidney Cells J. Biol. Chem., May 12, 2000; 275(20): 15207 - 15219. [Abstract] [Full Text] [PDF]
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S. C.D. van IJzendoorn and D. Hoekstra Polarized Sphingolipid Transport from the Subapical Compartment Changes during Cell Polarity Development Mol. Biol. Cell, March 1, 2000; 11(3): 1093 - 1101. [Abstract] [Full Text]
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R. Feniger-Barish, D. Belkin, A. Zaslaver, S. Gal, M. Dori, M. Ran, and A. Ben-Baruch GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR+-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling Blood, March 1, 2000; 95(5): 1551 - 1559. [Abstract] [Full Text] [PDF]
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C. Bucci, P. Thomsen, P. Nicoziani, J. McCarthy, and B. van Deurs Rab7: A Key to Lysosome Biogenesis Mol. Biol. Cell, February 1, 2000; 11(2): 467 - 480. [Abstract] [Full Text]
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D. Cox, D. J. Lee, B. M. Dale, J. Calafat, and S. Greenberg A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis PNAS, January 18, 2000; 97(2): 680 - 685. [Abstract] [Full Text] [PDF]
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U Rescher, N Zobiack, and V Gerke Intact Ca(2+)-binding sites are required for targeting of annexin 1 to endosomal membranes in living HeLa cells J. Cell Sci., January 11, 2000; 113(22): 3931 - 3938. [Abstract] [PDF]
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J Somsel Rodman and A Wandinger-Ness Rab GTPases coordinate endocytosis J. Cell Sci., January 1, 2000; 113(2): 183 - 192. [Abstract] [PDF]
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T.-S. Jou, S.-M. Leung, L. M. Fung, W. G. Ruiz, W. J. Nelson, and G. Apodaca Selective Alterations in Biosynthetic and Endocytic Protein Traffic in Madin-Darby Canine Kidney Epithelial Cells Expressing Mutants of the Small GTPase Rac1 Mol. Biol. Cell, January 1, 2000; 11(1): 287 - 304. [Abstract] [Full Text]
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N.-O. Ku, X. Zhou, D. M. Toivola, and M. B. Omary The cytoskeleton of digestive epithelia in health and disease Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1108 - G1137. [Abstract] [Full Text] [PDF]
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S.-M. Leung, R. Rojas, C. Maples, C. Flynn, W. G. Ruiz, T.-S. Jou, and G. Apodaca Modulation of Endocytic Traffic in Polarized Madin-Darby Canine Kidney Cells by the Small GTPase RhoA Mol. Biol. Cell, December 1, 1999; 10(12): 4369 - 4384. [Abstract] [Full Text]
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I. Fialka, P. Steinlein, H. Ahorn, G. Bock, P. D. Burbelo, M. Haberfellner, F. Lottspeich, K. Paiha, C. Pasquali, and L. A. Huber Identification of Syntenin as a Protein of the Apical Early Endocytic Compartment in Madin-Darby Canine Kidney Cells J. Biol. Chem., September 10, 1999; 274(37): 26233 - 26239. [Abstract] [Full Text] [PDF]
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M. Verges, R. J. Havel, and K. E. Mostov A tubular endosomal fraction from rat liver: Biochemical evidence of receptor sorting by default PNAS, August 31, 1999; 96(18): 10146 - 10151. [Abstract] [Full Text] [PDF]
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X. Wang, R. Kumar, J. Navarre, J. E. Casanova, and J. R. Goldenring Regulation of Vesicle Trafficking in Madin-Darby Canine Kidney Cells by Rab11a and Rab25 J. Biol. Chem., September 8, 2000; 275(37): 29138 - 29146. [Abstract] [Full Text] [PDF]
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G. Lalli and G. Schiavo Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR J. Cell Biol., January 21, 2002; 156(2): 233 - 240. [Abstract] [Full Text] [PDF]
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