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Vol. 10, Issue 1, 47-61, January 1999

Association of Rab25 and Rab11a with the Apical Recycling System of Polarized Madin-Darby Canine Kidney Cells

James E. Casanova,* Xiaoye Wang,* Ravindra Kumar,dagger Sheela G. Bhartur,dagger Jennifer Navarre,dagger Julie E. Woodrum,dagger Yoram Altschuler,Dagger Greg S. Ray,dagger and James R. Goldenringdagger §

 dagger Institute for Molecular Medicine and Genetics, Departments of Medicine, Surgery, Cellular Biology and Anatomy, Medical College of Georgia and the Augusta Veterans Affairs Medical Center, Augusta, Georgia 30912;  *Pediatric Gastroenterology Unit, Massachusetts General Hospital East, and Program in Biological and Biomedical Sciences, Harvard University Medical School, Charlestown, Massachusetts 02129; and  Dagger Department of Anatomy, University of California, San Francisco, California 94143

Recent evidence suggests that apical and basolateral endocytic pathways in epithelia converge in an apically located, pericentriolar endosomal compartment termed the apical recycling endosome. In this compartment, apically and basolaterally internalized membrane constituents are thought to be sorted for recycling back to their site of origin or for transcytosis to the opposite plasma membrane domain. We report here that in the epithelial cell line Madin-Darby Canine Kidney (MDCK), antibodies to Rab11a label an apical pericentriolar endosomal compartment that is dependent on intact microtubules for its integrity. Furthermore, this compartment is accessible to a membrane-bound marker (dimeric immunoglobulin A [IgA]) internalized from either the apical or basolateral pole, functionally defining it as the apical recycling endosome. We have also examined the role of a closely related epithelial-specific Rab, Rab25, in the regulation of membrane recycling and transcytosis in MDCK cells. When cDNA encoding Rab25 was transfected into MDCK cells, the protein colocalized with Rab11a in subapical vesicles. Rab25 transfection also altered the distribution of Rab11a, causing the coalescence of immunoreactivity into multiple denser vesicular structures not associated with the centrosome. Nevertheless, nocodazole still dispersed these vesicles, and dimeric IgA internalized from either the apical or basolateral membrane was detected in endosomes labeled with antibodies to both Rab11a and Rab25. Overexpression of Rab25 decreased the rate of IgA transcytosis and of apical, but not basolateral, recycling of internalized ligand. Conversely, expression of the dominant-negative Rab25T26N did not alter either apical recycling or transcytosis. These results indicate that both Rab11a and Rab25 associate with the apical recycling system of epithelial cells and suggest that Rab25 may selectively regulate the apical recycling and/or transcytotic pathways.


§   Corresponding author. E-mail address: jgolden{at}mail.mcg.edu.


Molecular Biology of the Cell
Vol. 10, 47-61, January 1999
Copyright © 1999 by The American Society for Cell Biology



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[Abstract] [Full Text] [PDF]


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J. Cell Sci., March 9, 2002; 114(14): 2617 - 2626.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
L. Kolesnikova, H. Bugany, H.-D. Klenk, and S. Becker
VP40, the Matrix Protein of Marburg Virus, Is Associated with Membranes of the Late Endosomal Compartment
J. Virol., February 15, 2002; 76(4): 1825 - 1838.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. M. Hales, R. Griner, K. C. Hobdy-Henderson, M. C. Dorn, D. Hardy, R. Kumar, J. Navarre, E. K. L. Chan, L. A. Lapierre, and J. R. Goldenring
Identification and Characterization of a Family of Rab11-interacting Proteins
J. Biol. Chem., October 12, 2001; 276(42): 39067 - 39075.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
J. R. Goldenring
Pools of actin in polarized cells: some filaments are more stable than others.: Focus on "Functionally distinct pools of actin in secretory cells"
Am J Physiol Cell Physiol, August 1, 2001; 281(2): C386 - C387.
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Mol. Biol. CellHome page
R. Rojas, W. G. Ruiz, S.-M. Leung, T.-S. Jou, and G. Apodaca
Cdc42-dependent Modulation of Tight Junctions and Membrane Protein Traffic in Polarized Madin-Darby Canine Kidney Cells
Mol. Biol. Cell, August 1, 2001; 12(8): 2257 - 2274.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
F. Jankovics, R. Sinka, and M. Erdelyi
An Interaction Type of Genetic Screen Reveals a Role of the Rab11 Gene in oskar mRNA Localization in the Developing Drosophila melanogaster Oocyte
Genetics, July 1, 2001; 158(3): 1177 - 1188.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
L. A. Lapierre, R. Kumar, C. M. Hales, J. Navarre, S. G. Bhartur, J. O. Burnette, D. W. Provance Jr., J. A. Mercer, M. Bahler, and J. R. Goldenring
Myosin Vb Is Associated with Plasma Membrane Recycling Systems
Mol. Biol. Cell, June 1, 2001; 12(6): 1843 - 1857.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
C. T Okamoto and J. G Forte
Vesicular trafficking machinery, the actin cytoskeleton, and H+-K+-ATPase recycling in the gastric parietal cell
J. Physiol., April 15, 2001; 532(2): 287 - 296.
[Abstract] [Full Text] [PDF]


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Physiol. Rev.Home page
Y. Takai, T. Sasaki, and T. Matozaki
Small GTP-Binding Proteins
Physiol Rev, January 1, 2001; 81(1): 153 - 208.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
R. Gagescu, N. Demaurex, R. G. Parton, W. Hunziker, L. A. Huber, and J. Gruenberg
The Recycling Endosome of Madin-Darby Canine Kidney Cells Is a Mildly Acidic Compartment Rich in Raft Components
Mol. Biol. Cell, August 1, 2000; 11(8): 2775 - 2791.
[Abstract] [Full Text]


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Mol. Biol. CellHome page
S.-M. Leung, W. G. Ruiz, and G. Apodaca
Sorting of Membrane and Fluid at the Apical Pole of Polarized Madin-Darby Canine Kidney Cells
Mol. Biol. Cell, June 1, 2000; 11(6): 2131 - 2150.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
E. Orzech, S. Cohen, A. Weiss, and B. Aroeti
Interactions between the Exocytic and Endocytic Pathways in Polarized Madin-Darby Canine Kidney Cells
J. Biol. Chem., May 12, 2000; 275(20): 15207 - 15219.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
S. C.D. van IJzendoorn and D. Hoekstra
Polarized Sphingolipid Transport from the Subapical Compartment Changes during Cell Polarity Development
Mol. Biol. Cell, March 1, 2000; 11(3): 1093 - 1101.
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BloodHome page
R. Feniger-Barish, D. Belkin, A. Zaslaver, S. Gal, M. Dori, M. Ran, and A. Ben-Baruch
GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR+-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling
Blood, March 1, 2000; 95(5): 1551 - 1559.
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Mol. Biol. CellHome page
C. Bucci, P. Thomsen, P. Nicoziani, J. McCarthy, and B. van Deurs
Rab7: A Key to Lysosome Biogenesis
Mol. Biol. Cell, February 1, 2000; 11(2): 467 - 480.
[Abstract] [Full Text]


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Proc. Natl. Acad. Sci. USAHome page
D. Cox, D. J. Lee, B. M. Dale, J. Calafat, and S. Greenberg
A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis
PNAS, January 18, 2000; 97(2): 680 - 685.
[Abstract] [Full Text] [PDF]


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J. Cell Sci.Home page
U Rescher, N Zobiack, and V Gerke
Intact Ca(2+)-binding sites are required for targeting of annexin 1 to endosomal membranes in living HeLa cells
J. Cell Sci., January 11, 2000; 113(22): 3931 - 3938.
[Abstract] [PDF]


Home page
J. Cell Sci.Home page
J Somsel Rodman and A Wandinger-Ness
Rab GTPases coordinate endocytosis
J. Cell Sci., January 1, 2000; 113(2): 183 - 192.
[Abstract] [PDF]


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Mol. Biol. CellHome page
T.-S. Jou, S.-M. Leung, L. M. Fung, W. G. Ruiz, W. J. Nelson, and G. Apodaca
Selective Alterations in Biosynthetic and Endocytic Protein Traffic in Madin-Darby Canine Kidney Epithelial Cells Expressing Mutants of the Small GTPase Rac1
Mol. Biol. Cell, January 1, 2000; 11(1): 287 - 304.
[Abstract] [Full Text]


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Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N.-O. Ku, X. Zhou, D. M. Toivola, and M. B. Omary
The cytoskeleton of digestive epithelia in health and disease
Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1108 - G1137.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
S.-M. Leung, R. Rojas, C. Maples, C. Flynn, W. G. Ruiz, T.-S. Jou, and G. Apodaca
Modulation of Endocytic Traffic in Polarized Madin-Darby Canine Kidney Cells by the Small GTPase RhoA
Mol. Biol. Cell, December 1, 1999; 10(12): 4369 - 4384.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
I. Fialka, P. Steinlein, H. Ahorn, G. Bock, P. D. Burbelo, M. Haberfellner, F. Lottspeich, K. Paiha, C. Pasquali, and L. A. Huber
Identification of Syntenin as a Protein of the Apical Early Endocytic Compartment in Madin-Darby Canine Kidney Cells
J. Biol. Chem., September 10, 1999; 274(37): 26233 - 26239.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
M. Verges, R. J. Havel, and K. E. Mostov
A tubular endosomal fraction from rat liver: Biochemical evidence of receptor sorting by default
PNAS, August 31, 1999; 96(18): 10146 - 10151.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
X. Wang, R. Kumar, J. Navarre, J. E. Casanova, and J. R. Goldenring
Regulation of Vesicle Trafficking in Madin-Darby Canine Kidney Cells by Rab11a and Rab25
J. Biol. Chem., September 8, 2000; 275(37): 29138 - 29146.
[Abstract] [Full Text] [PDF]


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JCBHome page
G. Lalli and G. Schiavo
Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR
J. Cell Biol., January 21, 2002; 156(2): 233 - 240.
[Abstract] [Full Text] [PDF]




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