![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 10, Issue 11, 3801-3813, November 1999
and
*Department of Biochemistry, The Cancer Institute of the Japanese
Foundation for Cancer Research and Research for the Future Program,
Japan Society for the Promotion of Science, Tokyo 170-8455, Japan;
The biological effects of type I serine/threonine kinase receptors
and Smad proteins were examined using an adenovirus-based vector
system. Constitutively active forms of bone morphogenetic protein (BMP)
type I receptors (BMPR-IA and BMPR-IB; BMPR-I group) and those of
activin receptor-like kinase (ALK)-1 and ALK-2 (ALK-1 group) induced
alkaline phosphatase activity in C2C12 cells. Receptor-regulated Smads (R-Smads) that act in the BMP pathways, such as Smad1 and Smad5,
also induced the alkaline phosphatase activity in C2C12 cells. BMP-6
dramatically enhanced alkaline phosphatase activity induced by Smad1 or
Smad5, probably because of the nuclear translocation of R-Smads
triggered by the ligand. Inhibitory Smads, i.e., Smad6 and Smad7,
repressed the alkaline phosphatase activity induced by BMP-6 or the
type I receptors. Chondrogenic differentiation of ATDC5 cells
was induced by the receptors of the BMPR-I group but not by those of
the ALK-1 group. However, kinase-inactive forms of the receptors of the
ALK-1 and BMPR-I groups blocked chondrogenic differentiation. Although
R-Smads failed to induce cartilage nodule formation, inhibitory Smads
blocked it. Osteoblast differentiation induced by BMPs is thus mediated
mainly via the Smad-signaling pathway, whereas chondrogenic
differentiation may be transmitted by Smad-dependent and independent pathways.
Department of Biomaterials Science and
Second Department of Oral Surgery, Faculty of Dentistry,
Tokyo Medical and Dental University, Tokyo 113-8549, Japan; and
§Creative BioMolecules, Hopkinton, Massachusetts 01748
Corresponding author. E-mail address:
fjios2{at}dent.tmd.ac.jp.
This article has been cited by other articles:
|
|
 |
|
  H. Geng, R. Lan, G. Wang, A. R. Siddiqi, M. C. Naski, A. I. Brooks, J. L. Barnes, P. Saikumar, J. M. Weinberg, and M. A. Venkatachalam Inhibition of Autoregulated TGF{beta} Signaling Simultaneously Enhances Proliferation and Differentiation of Kidney Epithelium and Promotes Repair Following Renal Ischemia Am. J. Pathol., April 1, 2009; 174(4): 1291 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Retting, B. Song, B. S. Yoon, and K. M. Lyons BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation Development, April 1, 2009; 136(7): 1093 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Iwai, J. Murai, H. Yoshikawa, and N. Tsumaki Smad7 Inhibits Chondrocyte Differentiation at Multiple Steps during Endochondral Bone Formation and Down-regulates p38 MAPK Pathways J. Biol. Chem., October 3, 2008; 283(40): 27154 - 27164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nakashima, T. Kawamoto, K. K. Honda, T. Ueshima, M. Noshiro, T. Iwata, K. Fujimoto, H. Kubo, S. Honma, N. Yorioka, et al. DEC1 Modulates the Circadian Phase of Clock Gene Expression Mol. Cell. Biol., June 15, 2008; 28(12): 4080 - 4092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Itoh, S. Kanno, Z. Gai, H. Suemoto, M. Kawakatsu, H. Tanishima, Y. Morimoto, K. Nishioka, I. Hatamura, M. Yoshida, et al. Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells, April 1, 2008; 13(4): 355 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Jeon, H. J. Moon, M. J. Lee, H. Y. Song, Y. M. Kim, M. Cho, D.-S. Suh, M.-S. Yoon, C. L. Chang, J. S. Jung, et al. Cancer-Derived Lysophosphatidic Acid Stimulates Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells Stem Cells, March 1, 2008; 26(3): 789 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lagna, M. M. Ku, P. H. Nguyen, N. A. Neuman, B. N. Davis, and A. Hata Control of Phenotypic Plasticity of Smooth Muscle Cells by Bone Morphogenetic Protein Signaling through the Myocardin-related Transcription Factors J. Biol. Chem., December 21, 2007; 282(51): 37244 - 37255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Chan, P. H. Nguyen, B. N. Davis, N. Ohoka, H. Hayashi, K. Du, G. Lagna, and A. Hata A Novel Regulatory Mechanism of the Bone Morphogenetic Protein (BMP) Signaling Pathway Involving the Carboxyl-Terminal Tail Domain of BMP Type II Receptor Mol. Cell. Biol., August 15, 2007; 27(16): 5776 - 5789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Goto, Y. Kamiya, T. Imamura, K. Miyazono, and K. Miyazawa Selective Inhibitory Effects of Smad6 on Bone Morphogenetic Protein Type I Receptors J. Biol. Chem., July 13, 2007; 282(28): 20603 - 20611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Lien, O. K. Lee, and Y. Su Cbfb Enhances the Osteogenic Differentiation of Both Human and Mouse Mesenchymal Stem Cells Induced by Cbfa-1 via Reducing Its Ubiquitination-Mediated Degradation Stem Cells, June 1, 2007; 25(6): 1462 - 1468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Scherner, S. K. Meurer, L. Tihaa, A. M. Gressner, and R. Weiskirchen Endoglin Differentially Modulates Antagonistic Transforming Growth Factor-beta1 and BMP-7 Signaling J. Biol. Chem., May 11, 2007; 282(19): 13934 - 13943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mishima, T. Watabe, A. Saito, Y. Yoshimatsu, N. Imaizumi, S. Masui, M. Hirashima, T. Morisada, Y. Oike, M. Araie, et al. Prox1 Induces Lymphatic Endothelial Differentiation via Integrin {alpha}9 and Other Signaling Cascades Mol. Biol. Cell, April 1, 2007; 18(4): 1421 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kondo, C. Shukunami, Y. Morioka, N. Matsumoto, R. Takahashi, J. Oh, T. Atsumi, A. Umezawa, A. Kudo, H. Kitayama, et al. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells J. Cell Sci., March 1, 2007; 120(5): 849 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Wang, A. Narasanna, C. W. Whitell, F. Y. Wu, D. B. Friedman, and C. L. Arteaga Convergence of p53 and Transforming Growth Factor beta (TGFbeta) Signaling on Activating Expression of the Tumor Suppressor Gene maspin in Mammary Epithelial Cells J. Biol. Chem., February 23, 2007; 282(8): 5661 - 5669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mallet, D. Vittet, J.-J. Feige, and S. Bailly TGF{beta}1 Induces Vasculogenesis and Inhibits Angiogenic Sprouting in an Embryonic Stem Cell Differentiation Model: Respective Contribution of ALK1 and ALK5 Stem Cells, November 1, 2006; 24(11): 2420 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. I. Koleva, B. A. Conley, D. Romero, K. S. Riley, J. A. Marto, A. Lux, and C. P. H. Vary Endoglin Structure and Function: DETERMINANTS OF ENDOGLIN PHOSPHORYLATION BY TRANSFORMING GROWTH FACTOR-beta RECEPTORS J. Biol. Chem., September 1, 2006; 281(35): 25110 - 25123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shirakawa, S. Maeda, T. Gotoh, M. Hayashi, K. Shinomiya, S. Ehata, R. Nishimura, M. Mori, K. Onozaki, H. Hayashi, et al. CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Regulates Osteoblast Differentiation. Mol. Cell. Biol., August 1, 2006; 26(16): 6105 - 6116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ku, S. Howard, W. Ni, G. Lagna, and A. Hata OAZ Regulates Bone Morphogenetic Protein Signaling through Smad6 Activation J. Biol. Chem., February 24, 2006; 281(8): 5277 - 5287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ichijo, A. Voutetakis, A. P. Cotrim, N. Bhattachryya, M. Fujii, G. P. Chrousos, and T. Kino The Smad6-Histone Deacetylase 3 Complex Silences the Transcriptional Activity of the Glucocorticoid Receptor: POTENTIAL CLINICAL IMPLICATIONS J. Biol. Chem., December 23, 2005; 280(51): 42067 - 42077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Azuma, S. Ehata, H. Miyazaki, T. Watabe, O. Maruyama, T. Imamura, T. Sakamoto, S. Kiyama, Y. Kiyama, T. Ubai, et al. Effect of Smad7 Expression on Metastasis of Mouse Mammary Carcinoma JygMC(A) Cells J Natl Cancer Inst, December 7, 2005; 97(23): 1734 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Kim, H.-A. Kim, H.-S. Jong, J.-H. Park, N. K. Kim, S. H. Hong, T.-Y. Kim, and Y.-J. Bang The Endogenous Ratio of Smad2 and Smad3 Influences the Cytostatic Function of Smad3 Mol. Biol. Cell, October 1, 2005; 16(10): 4672 - 4683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hoffmann, O. Preobrazhenska, C. Wodarczyk, Y. Medler, A. Winkel, S. Shahab, D. Huylebroeck, G. Gross, and K. Verschueren Transforming Growth Factor-{beta}-activated Kinase-1 (TAK1), a MAP3K, Interacts with Smad Proteins and Interferes with Osteogenesis in Murine Mesenchymal Progenitors J. Biol. Chem., July 22, 2005; 280(29): 27271 - 27283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Yu, H. Beppu, N. Kawai, E. Li, and K. D. Bloch Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells J. Biol. Chem., July 1, 2005; 280(26): 24443 - 24450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Brown, Q. Zhao, K. A. Baker, C. Naik, C. Chen, L. Pukac, M. Singh, T. Tsareva, Y. Parice, A. Mahoney, et al. Crystal Structure of BMP-9 and Functional Interactions with Pro-region and Receptors J. Biol. Chem., July 1, 2005; 280(26): 25111 - 25118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kopp, E. Preis, H. Said, B. Hafemann, L. Wickert, A. M. Gressner, N. Pallua, and S. Dooley|| Abrogation of Transforming Growth Factor-{beta} Signaling by SMAD7 Inhibits Collagen Gel Contraction of Human Dermal Fibroblasts J. Biol. Chem., June 3, 2005; 280(22): 21570 - 21576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Wang, F. Y. Wu, I. Shin, S. Qu, and C. L. Arteaga Transforming Growth Factor {beta} (TGF-{beta})-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-{beta} Function Mol. Cell. Biol., June 1, 2005; 25(11): 4703 - 4715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Yoon, D. A. Ovchinnikov, I. Yoshii, Y. Mishina, R. R. Behringer, and K. M. Lyons Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo PNAS, April 5, 2005; 102(14): 5062 - 5067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Valcourt, M. Kowanetz, H. Niimi, C.-H. Heldin, and A. Moustakas TGF-{beta} and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition Mol. Biol. Cell, April 1, 2005; 16(4): 1987 - 2002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Vardouli, A. Moustakas, and C. Stournaras LIM-kinase 2 and Cofilin Phosphorylation Mediate Actin Cytoskeleton Reorganization Induced by Transforming Growth Factor-{beta} J. Biol. Chem., March 25, 2005; 280(12): 11448 - 11457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Furumatsu, M. Tsuda, N. Taniguchi, Y. Tajima, and H. Asahara Smad3 Induces Chondrogenesis through the Activation of SOX9 via CREB-binding Protein/p300 Recruitment J. Biol. Chem., March 4, 2005; 280(9): 8343 - 8350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sammar, S. Stricker, G. C. Schwabe, C. Sieber, A. Hartung, M. Hanke, I. Oishi, J. Pohl, Y. Minami, W. Sebald, et al. Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2 Genes Cells, December 1, 2004; 9(12): 1227 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Reinhold, M. Abe, R. M. Kapadia, Z. Liao, and M. C. Naski FGF18 Represses Noggin Expression and Is Induced by Calcineurin J. Biol. Chem., September 10, 2004; 279(37): 38209 - 38219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. C. de Sousa Lopes, B. A.J. Roelen, R. M. Monteiro, R. Emmens, H. Y. Lin, E. Li, K. A. Lawson, and C. L. Mummery BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo Genes & Dev., August 1, 2004; 18(15): 1838 - 1849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mochizuki, H. Miyazaki, T. Hara, T. Furuya, T. Imamura, T. Watabe, and K. Miyazono Roles for the MH2 Domain of Smad7 in the Specific Inhibition of Transforming Growth Factor-{beta} Superfamily Signaling J. Biol. Chem., July 23, 2004; 279(30): 31568 - 31574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Kim, H. van Gelder, T. A. Kim, H.-J. Lee, K. G. Baik, H. H. Chun, D. A. Lee, K. S. Choi, and S.-J. Kim Activin Receptor-like Kinase-7 Induces Apoptosis through Activation of MAPKs in a Smad3-dependent Mechanism in Hepatoma Cells J. Biol. Chem., July 2, 2004; 279(27): 28458 - 28465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Kim, H.-J. Lee, S. H. Park, S. R. Lee, T. S. Karpova, J. G. McNally, A. Felici, D. K. Lee, and S.-J. Kim Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor {beta} Signaling by Binding to Smad7 and Promoting Its Degradation Mol. Cell. Biol., March 15, 2004; 24(6): 2251 - 2262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takeda, M. Mizuide, M. Oka, T. Watabe, H. Inoue, H. Suzuki, T. Fujita, T. Imamura, K. Miyazono, and K. Miyazawa Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski Mol. Biol. Cell, March 1, 2004; 15(3): 963 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson The Bone Morphogenetic Protein System In Mammalian Reproduction Endocr. Rev., February 1, 2004; 25(1): 72 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Shi, H. Chen, J. Sun, C. Chen, J. Zhao, Y.-L. Wang, K. D. Anderson, and D. Warburton Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L293 - L300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Kim, H.-S. Jong, T.-Y. Kim, J. W. Lee, N. K. Kim, S. H. Hong, and Y.-J. Bang Transforming Growth Factor-{beta}1 Induces Apoptosis through Fas Ligand-independent Activation of the Fas Death Pathway in Human Gastric SNU-620 Carcinoma Cells Mol. Biol. Cell, February 1, 2004; 15(2): 420 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hay, J. Lemonnier, O. Fromigue, H. Guenou, and P. J. Marie Bone Morphogenetic Protein Receptor IB Signaling Mediates Apoptosis Independently of Differentiation in Osteoblastic Cells J. Biol. Chem., January 16, 2004; 279(3): 1650 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Buckley, W. Shi, B. Driscoll, A. Ferrario, K. Anderson, and D. Warburton BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L81 - L86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, J. Lee, M. Cooley, E. Bhogte, S. Hartley, and A. Glick Smad7 but not Smad6 Cooperates with Oncogenic ras to Cause Malignant Conversion in a Mouse Model for Squamous Cell Carcinoma Cancer Res., November 15, 2003; 63(22): 7760 - 7768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Matsuyama, M. Iwadate, M. Kondo, M. Saitoh, A. Hanyu, K. Shimizu, H. Aburatani, H. K. Mishima, T. Imamura, K. Miyazono, et al. SB-431542 and Gleevec Inhibit Transforming Growth Factor-{beta}-Induced Proliferation of Human Osteosarcoma Cells Cancer Res., November 15, 2003; 63(22): 7791 - 7798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-X. Ying, Z. J. Hussain, and Y. E. Zhang Smurf1 Facilitates Myogenic Differentiation and Antagonizes the Bone Morphogenetic Protein-2-induced Osteoblast Conversion by Targeting Smad5 for Degradation J. Biol. Chem., October 3, 2003; 278(40): 39029 - 39036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xiao, A. M. Brownawell, I. G. Macara, and H. F. Lodish A Novel Nuclear Export Signal in Smad1 Is Essential for Its Signaling Activity J. Biol. Chem., September 5, 2003; 278(36): 34245 - 34252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Lee, Y.-J. Kim, H.-J. Kim, H.-D. Park, A.-R. Kang, H.-M. Kyung, J.-H. Sung, J. M. Wozney, H.-J. Kim, and H.-M. Ryoo BMP-2-induced Runx2 Expression Is Mediated by Dlx5, and TGF-{beta}1 Opposes the BMP-2-induced Osteoblast Differentiation by Suppression of Dlx5 Expression J. Biol. Chem., September 5, 2003; 278(36): 34387 - 34394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hatakeyama, J. Nguyen, X. Wang, G. H. Nuckolls, and L. Shum Smad Signaling in Mesenchymal and Chondroprogenitor Cells J. Bone Joint Surg. Am., August 1, 2003; 85(90003): 13 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kurisaki, A. Kurisaki, U. Valcourt, A. A. Terentiev, K. Pardali, P. ten Dijke, C.-H. Heldin, J. Ericsson, and A. Moustakas Nuclear Factor YY1 Inhibits Transforming Growth Factor {beta}- and Bone Morphogenetic Protein-Induced Cell Differentiation Mol. Cell. Biol., July 1, 2003; 23(13): 4494 - 4510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Vijayachandra, J. Lee, and A. B. Glick Smad3 Regulates Senescence and Malignant Conversion in a Mouse Multistage Skin Carcinogenesis Model Cancer Res., July 1, 2003; 63(13): 3447 - 3452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Oda, K. Suardita, K. Fujimoto, H. Pan, W. Yan, A. Shimazu, H. Shintani, and Y. Kato Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A J. Cell Sci., May 15, 2003; 116(10): 2029 - 2038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Canalis, A. N. Economides, and E. Gazzerro Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton Endocr. Rev., April 1, 2003; 24(2): 218 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Wada, M. Inagawa-Ogashiwa, S. Shimizu, S. Yasumoto, and N. Hashimoto Generation of different fates from multipotent muscle stem cells Development, March 8, 2003; 129(12): 2987 - 2995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Chou, V. Prokova, K. Shiraishi, U. Valcourt, A. Moustakas, M. Hadzopoulou-Cladaras, V. I. Zannis, and D. Kardassis Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-beta -regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4 Mol. Biol. Cell, March 1, 2003; 14(3): 1279 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kaivo-Oja, J. Bondestam, M. Kamarainen, J. Koskimies, U. Vitt, M. Cranfield, K. Vuojolainen, J. P. Kallio, V. M. Olkkonen, M. Hayashi, et al. Growth Differentiation Factor-9 Induces Smad2 Activation and Inhibin B Production in Cultured Human Granulosa-Luteal Cells J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 755 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Dumont, A. V. Bakin, and C. L. Arteaga Autocrine Transforming Growth Factor-beta Signaling Mediates Smad-independent Motility in Human Cancer Cells J. Biol. Chem., January 24, 2003; 278(5): 3275 - 3285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ishisaki, H. Hayashi, A.-J. Li, and T. Imamura Human Umbilical Vein Endothelium-derived Cells Retain Potential to Differentiate into Smooth Muscle-like Cells J. Biol. Chem., January 3, 2003; 278(2): 1303 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lamouille, C. Mallet, J.-J. Feige, and S. Bailly Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis Blood, December 15, 2002; 100(13): 4495 - 4501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shen, E. Yoshida, W. Yan, T. Kawamoto, K. Suardita, Y. Koyano, K. Fujimoto, M. Noshiro, and Y. Kato Basic Helix-loop-helix Protein DEC1 Promotes Chondrocyte Differentiation at the Early and Terminal Stages J. Biol. Chem., December 13, 2002; 277(51): 50112 - 50120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tomita, M. I. Reinhold, J. D. Molkentin, and M. C. Naski Calcineurin and NFAT4 Induce Chondrogenesis J. Biol. Chem., October 25, 2002; 277(44): 42214 - 42218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Skillington, L. Choy, and R. Derynck Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes J. Cell Biol., October 14, 2002; 159(1): 135 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Valcourt, J. Gouttenoire, A. Moustakas, D. Herbage, and F. Mallein-Gerin Functions of Transforming Growth Factor-beta Family Type I Receptors and Smad Proteins in the Hypertrophic Maturation and Osteoblastic Differentiation of Chondrocytes J. Biol. Chem., September 6, 2002; 277(37): 33545 - 33558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nishihara, T. Watabe, T. Imamura, and K. Miyazono Functional Heterogeneity of Bone Morphogenetic Protein Receptor-II Mutants Found in Patients with Primary Pulmonary Hypertension Mol. Biol. Cell, September 1, 2002; 13(9): 3055 - 3063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Lai and S.-L. Cheng Signal Transductions Induced by Bone Morphogenetic Protein-2 and Transforming Growth Factor-beta in Normal Human Osteoblastic Cells J. Biol. Chem., May 3, 2002; 277(18): 15514 - 15522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Kim, M. Mamura, K. S. Choi, B. Calabretta, and S.-J. Kim Transforming Growth Factor {beta}1 Induces Apoptosis through Cleavage of BAD in a Smad3-Dependent Mechanism in FaO Hepatoma Cells Mol. Cell. Biol., March 1, 2002; 22(5): 1369 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hoffmann, S. Czichos, C. Kaps, D. Bachner, H. Mayer, Y. Zilberman, G. Turgeman, G. Pelled, G. Gross, and D. Gazit The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2 J. Cell Sci., February 15, 2002; 115(4): 769 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bai and X. Cao A Nuclear Antagonistic Mechanism of Inhibitory Smads in Transforming Growth Factor-beta Signaling J. Biol. Chem., February 1, 2002; 277(6): 4176 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Samuel, C. N. Nagineni, R. K. Kutty, W. T. Parks, J. S. Gordon, S. M. Prouty, J. J. Hooks, and B. Wiggert Transforming Growth Factor-beta Regulates Stearoyl Coenzyme A Desaturase Expression through a Smad Signaling Pathway J. Biol. Chem., January 4, 2002; 277(1): 59 - 66. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Theilhaber, T. Connolly, S. Roman-Roman, S. Bushnell, A. Jackson, K. Call, T. Garcia, and R. Baron Finding Genes in the C2C12 Osteogenic Pathway by k-Nearest-Neighbor Classification of Expression Data Genome Res., January 1, 2002; 12(1): 165 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hanyu, Y. Ishidou, T. Ebisawa, T. Shimanuki, T. Imamura, and K. Miyazono The N domain of Smad7 is essential for specific inhibition of transforming growth factor-{beta} signaling J. Cell Biol., December 10, 2001; 155(6): 1017 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tylzanowski, K. Verschueren, D. Huylebroeck, and F. P. Luyten Smad-interacting Protein 1 Is a Repressor of Liver/Bone/Kidney Alkaline Phosphatase Transcription in Bone Morphogenetic Protein-induced Osteogenic Differentiation of C2C12 Cells J. Biol. Chem., October 19, 2001; 276(43): 40001 - 40007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Aoki, M Fujii, T Imamura, K Yagi, K Takehara, M Kato, and K Miyazono Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction J. Cell Sci., January 4, 2001; 114(8): 1483 - 1489. [Abstract] [PDF]
|
|
|
|
 |
|
 F. De Luca, K. M. Barnes, J. A. Uyeda, S. De-Levi, V. Abad, T. Palese, V. Mericq, and J. Baron Regulation of Growth Plate Chondrogenesis by Bone Morphogenetic Protein-2 Endocrinology, January 1, 2001; 142(1): 430 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-S. Lee, H.-J. Kim, Q.-L. Li, X.-Z. Chi, C. Ueta, T. Komori, J. M. Wozney, E.-G. Kim, J.-Y. Choi, H.-M. Ryoo, et al. Runx2 Is a Common Target of Transforming Growth Factor beta 1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12 Mol. Cell. Biol., December 1, 2000; 20(23): 8783 - 8792. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-W. Zhang, N. Yasui, K. Ito, G. Huang, M. Fujii, J.-i. Hanai, H. Nogami, T. Ochi, K. Miyazono, and Y. Ito A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia PNAS, August 23, 2000; (2000) 180309597. [Abstract] [Full Text]
|
|
|
|
|
|
A. Yamaguchi, T. Komori, and T. Suda Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1 Endocr. Rev., August 1, 2000; 21(4): 393 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ishida, T. Hamamoto, K. Kusanagi, K. Yagi, M. Kawabata, K. Takehara, T. K. Sampath, M. Kato, and K. Miyazono Smad6 Is a Smad1/5-induced Smad Inhibitor. CHARACTERIZATION OF BONE MORPHOGENETIC PROTEIN-RESPONSIVE ELEMENT IN THE MOUSE Smad6 PROMOTER J. Biol. Chem., February 25, 2000; 275(9): 6075 - 6079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Watanabe, M. P. de Caestecker, and Y. Yamada Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-beta -induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells J. Biol. Chem., April 20, 2001; 276(17): 14466 - 14473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nishimori, Y. Tanaka, T. Chiba, M. Fujii, T. Imamura, K. Miyazono, T. Ogasawara, H. Kawaguchi, T. Igarashi, T. Fujita, et al. Smad-mediated Transcription Is Required for Transforming Growth Factor-beta 1-induced p57Kip2 Proteolysis in Osteoblastic Cells J. Biol. Chem., March 30, 2001; 276(14): 10700 - 10705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Izumi, Y. Fujio, K. Kunisada, S. Negoro, E. Tone, M. Funamoto, T. Osugi, Y. Oshima, Y. Nakaoka, T. Kishimoto, et al. Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway J. Biol. Chem., August 10, 2001; 276(33): 31133 - 31141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Piek, W. J. Ju, J. Heyer, D. Escalante-Alcalde, C. L. Stewart, M. Weinstein, C. Deng, R. Kucherlapati, E. P. Bottinger, and A. B. Roberts Functional Characterization of Transforming Growth Factor beta Signaling in Smad2- and Smad3-deficient Fibroblasts J. Biol. Chem., June 1, 2001; 276(23): 19945 - 19953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Pardali, A. Kurisaki, A. Moren, P. ten Dijke, D. Kardassis, and A. Moustakas Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-beta J. Biol. Chem., September 15, 2000; 275(38): 29244 - 29256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Zhang, N. Yasui, K. Ito, G. Huang, M. Fujii, J.-i. Hanai, H. Nogami, T. Ochi, K. Miyazono, and Y. Ito A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia PNAS, September 12, 2000; 97(19): 10549 - 10554. [Abstract] [Full Text] [PDF]
|
|
