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Vol. 10, Issue 11, 3815-3824, November 1999
*E. C. Slater Instituut, University of Amsterdam, BioCentrum
Amsterdam, 1018 TV Amsterdam, The Netherlands; and
Nuclear domains, called cleavage bodies, are enriched in the RNA
3'-processing factors CstF 64 kDa and and CPSF 100 kDa. Cleavage bodies
have been found either overlapping with or adjacent to coiled bodies.
To determine whether the spatial relationship between cleavage bodies
and coiled bodies was influenced by the cell cycle, we performed cell
synchronization studies. We found that in G1 phase cleavage bodies and
coiled bodies were predominantly coincident, whereas in S phase they
were mostly adjacent to each other. In G2 cleavage bodies were often
less defined or absent, suggesting that they disassemble at this point
in the cell cycle. A small number of genetic loci have been reported to
be juxtaposed to coiled bodies, including the genes for U1 and U2 small
nuclear RNA as well as the two major histone gene clusters. Here
we show that cleavage bodies do not overlap with small nuclear RNA
genes but do colocalize with the histone genes next to coiled bodies. These findings demonstrate that the association of cleavage bodies and
coiled bodies is both dynamic and tightly regulated and suggest that
the interaction between these nuclear neighbors is related to the cell
cycle-dependent expression of histone genes.
Department of Genetics, Center for Human Genetics and
Program in Cell Biology, Case Western Reserve University, Cleveland,
Ohio 44106-4955
Corresponding author. E-mail address:
a311luit{at}chem.uva.nl.
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