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Vol. 10, Issue 11, 3825-3834, November 1999
Department of Molecular Biology and Oncology, University of Texas
Southwestern Medical Center, Dallas, Texas 75235-9148
The Drosophila fusome is a germ cell-specific
organelle assembled from membrane skeletal proteins and membranous
vesicles. Mutational studies that have examined inactivating alleles of fusome proteins indicate that the organelle plays central roles in germ
cell differentiation. Although mutations in genes encoding skeletal
fusome components prevent proper cyst formation, mutations in the
bag-of-marbles gene disrupt the assembly of membranous cisternae within the fusome and block cystoblast differentiation altogether. To understand the relationship between fusome cisternae and
cystoblast differentiation, we have begun to identify other proteins in
this network of fusome tubules. In this article we present evidence
that the fly homologue of the transitional endoplasmic reticulum ATPase
(TER94) is one such protein. The presence of TER94 suggests that the
fusome cisternae grow by vesicle fusion and are a germ cell
modification of endoplasmic reticulum. We also show that fusome
association of TER94 is Bam-dependent, suggesting that cystoblast
differentiation may be linked to fusome reticulum biogenesis.
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