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Vol. 10, Issue 2, 407-416, February 1999
1 in Human Prostate Cancer Cell Lines
*Scott Department of Urology, The type IV collagenases/gelatinases matrix metalloproteinase-2
(MMP-2) and MMP-9 play a variety of important roles in both physiological and pathological processes and are regulated by various
growth factors, including transforming growth factor-Department of Radiotherapy, Baylor College of Medicine, Houston,
Texas 77030
1 (TGF-1),
in several cell types. Previous studies have suggested that cellular
control of one or both collagenases can occur through direct
transcriptional mechanisms and/or after secretion through proenzyme
processing and interactions with metalloproteinase inhibitors. Using
human prostate cancer cell lines, we have found that TGF-1 induces
the MMP-9 proenzyme; however, this induction does not result from
direct effects on gene transcription but, instead, through a protein
synthesis-requiring process leading to increased MMP-9 mRNA stability.
In addition, we have examined levels of TGF-1 regulation of MMP-2 in
one prostate cancer cell line and found that TGF-1 induces higher
secreted levels of this collagenase through increased stability of the
secreted 72-kDa proenzyme. These results identify two novel
nontranscriptional pathways for the cellular regulation of MMP-9 and
MMP-2 collagenase gene expression and activities.
Corresponding author. E-mail address:
timothyt{at}bcm.tmc.edu.
Molecular Biology of the Cell
Vol. 10, 407-416, February 1999
Copyright © 1999 by The American Society for Cell Biology
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