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Vol. 10, Issue 4, 1235-1245, April 1999
Department of Cell and Developmental Biology,
Theodor-Boveri-Institute (Biocenter), University of Würzburg, Am
Hubland, D-97074 Würzburg, Germany
The nucleus of spermatocytes provides during the first meiotic
prophase an interesting model for investigating relationships of the
nuclear envelope (NE) with components of the nuclear interior. During
the pachytene stage, meiotic chromosomes are synapsed via synaptonemal
complexes (SCs) and attached through both ends to the nuclear
periphery. This association is dynamic because chromosomes move during
the process of synapsis and desynapsis that takes place during meiotic
prophase. The NE of spermatocytes possesses some peculiarities (e.g.,
lower stability than in somatic cells, expression of short
meiosis-specific lamin isoforms called C2 and B3) that could be
critically involved in this process. For better understanding of the
association of chromosomes with the nuclear periphery, in the present
study we have investigated the distribution of NE proteins in relation
to SC attachment sites. A major outcome was the finding that lamin C2
is distributed in the form of discontinuous domains at the NE of
spermatocytes and that SC attachment sites are embedded in these
domains. Lamin C2 appears to form part of larger structures as
suggested by cell fractionation experiments. According to these
results, we propose that the C2-containing domains represent local
reinforcements of the NE that are involved in the proper attachment of SCs.
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