![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 10, Issue 4, 861-873, April 1999
2 Integrins
Lymphocyte Function-associated Antigen-1 and Mac-1 by
Chemokines Mediated by Distinct Pathways via the 
Subunit
Cytoplasmic Domains
and
*Institut für Prophylaxe der Kreislaufkrankheiten,
Ludwig-Maximilians-Universität, D-80336 München, Germany;
and We show that CC chemokines induced a sustained
increase in monocyte adhesion to intercellular adhesion
molecule-1 that was mediated by Mac-1 (Division of Rheumatology, Immunology and Allergy,
Brigham and Women's Hospital, Harvard Medical School, Boston,
Massachusetts 02115
M
2) but not
lymphocyte function-associated antigen-1 (LFA-1; L2). In
contrast, staining for an activation epitope revealed a rapid and
transient up-regulation of LFA-1 activity by monocyte chemotactic
protein-1 (MCP-1) in monocytes and Jurkat CCR2 chemokine receptor
transfectants or by stromal-derived factor-1 in Jurkat cells.
Differential kinetics for activation of Mac-1 (sustained) and LFA-1
(transient) avidity in response to stromal-derived factor-1 were
confirmed by expression of M or L in L-deficient Jurkat cells.
Moreover, expression of chimeras containing L and M cytoplasmic
domain exchanges indicated that cytoplasmic tails conferred the
specific mode of regulation. Coexpressing M or chimeras in mutant
Jurkat cells with a "gain of function" phenotype that results in
constitutively active LFA-1 demonstrated that Mac-1 was not
constitutively active, whereas constitutive activity was mediated via
the L cytoplasmic tail, implying the presence of
distinct signaling pathways for LFA-1 and Mac-1. Transendothelial
chemotaxis of monocytes in response to MCP-1 was dependent on LFA-1;
however, Mac-1 was involved at MCP-1 concentrations stimulating its
avidity, showing differential contributions of 2 integrins.
Our data suggest that a specific regulation of 2 integrin
avidity by chemokines may be important in leukocyte extravasation and
may be triggered by distinct activation pathways transduced via the subunit cytoplasmic domains.
Corresponding author. E-mail
address: christian.weber{at}klp.med.uni-muenchen.de.
This article has been cited by other articles:
|
|
 |
|
  M. Hristov, A. Zernecke, K. Bidzhekov, E. A. Liehn, E. Shagdarsuren, A. Ludwig, and C. Weber Importance of CXC Chemokine Receptor 2 in the Homing of Human Peripheral Blood Endothelial Progenitor Cells to Sites of Arterial Injury Circ. Res., March 2, 2007; 100(4): 590 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Chavakis, A. Hain, M. Vinci, G. Carmona, M. E. Bianchi, P. Vajkoczy, A. M. Zeiher, T. Chavakis, and S. Dimmeler High-Mobility Group Box 1 Activates Integrin-Dependent Homing of Endothelial Progenitor Cells Circ. Res., February 2, 2007; 100(2): 204 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wimmer, S. K. Khaldoyanidi, M. Judex, N. Serobyan, R. G. DiScipio, and I. U. Schraufstatter CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes Blood, December 1, 2006; 108(12): 3722 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wiedemann, J. C. Patel, J. Lim, A. Tsun, Y. van Kooyk, and E. Caron Two distinct cytoplasmic regions of the {beta}2 integrin chain regulate RhoA function during phagocytosis. J. Cell Biol., March 27, 2006; 172(7): 1069 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Fagerholm, T. J. Hilden, S. M. Nurmi, and C. G. Gahmberg Specific integrin {alpha} and {beta} chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms J. Cell Biol., November 21, 2005; 171(4): 705 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sendide, N. E. Reiner, J. S. I. Lee, S. Bourgoin, A. Talal, and Z. Hmama Cross-Talk between CD14 and Complement Receptor 3 Promotes Phagocytosis of Mycobacteria: Regulation by Phosphatidylinositol 3-Kinase and Cytohesin-1 J. Immunol., April 1, 2005; 174(7): 4210 - 4219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Calderwood, J. M. Williams, M. D. Morgan, G. B. Nash, and C. O. S. Savage ANCA induces {beta}2 integrin and CXC chemokine-dependent neutrophil-endothelial cell interactions that mimic those of highly cytokine-activated endothelium J. Leukoc. Biol., January 1, 2005; 77(1): 33 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-P. Chuang, Y.-F. Huang, Y.-L. Hsu, H.-S. Liu, H.-C. Chen, and C.-C. Shieh Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway Blood, December 15, 2004; 104(13): 4046 - 4053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Baltus, K. S. C. Weber, Z. Johnson, A. E. I. Proudfoot, and C. Weber Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium Blood, September 15, 2003; 102(6): 1985 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Na, M. Marsden, and D. W. DeSimone Differential regulation of cell adhesive functions by integrin {alpha} subunit cytoplasmic tails in vivo J. Cell Sci., June 1, 2003; 116(11): 2333 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Maus, S. Henning, H. Wenschuh, K. Mayer, W. Seeger, and J. Lohmeyer Role of endothelial MCP-1 in monocyte adhesion to inflamed human endothelium under physiological flow Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2584 - H2591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Hyduk and M. I. Cybulsky {alpha}4 Integrin Signaling Activates Phosphatidylinositol 3-Kinase and Stimulates T Cell Adhesion to Intercellular Adhesion Molecule-1 to a Similar Extent As CD3, but Induces a Distinct Rearrangement of the Actin Cytoskeleton J. Immunol., January 15, 2002; 168(2): 696 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Dunne, C. M. Ballantyne, A. L. Beaudet, and K. Ley Control of leukocyte rolling velocity in TNF-alpha -induced inflammation by LFA-1 and Mac-1 Blood, January 1, 2002; 99(1): 336 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ronald, C. V. Ionescu, K. A. Rogers, and M. Sandig Differential regulation of transendothelial migration of THP-1 cells by ICAM-1/LFA-1 and VCAM-1/VLA-4 J. Leukoc. Biol., October 1, 2001; 70(4): 601 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S.C. Weber, G. Ostermann, A. Zernecke, A. Schroder, L. B. Klickstein, and C. Weber Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1alpha : Implications for Leukocyte Transmigration Mol. Biol. Cell, October 1, 2001; 12(10): 3074 - 3086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rezzonico, V. Imbert, R. Chicheportiche, and J.-M. Dayer Ligation of CD11b and CD11c {beta}2 integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1{alpha} (MIP-1{alpha}) and MIP-1{beta} production in primary human monocytes through a pathway dependent on nuclear factor-{kappa}B Blood, May 15, 2001; 97(10): 2932 - 2940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. M. Soede, I. S. Zeelenberg, Y. M. Wijnands, M. Kamp, and E. Roos Stromal Cell-Derived Factor-1-Induced LFA-1 Activation During In Vivo Migration of T Cell Hybridoma Cells Requires Gq/11, RhoA, and Myosin, as well as Gi and Cdc42 J. Immunol., April 1, 2001; 166(7): 4293 - 4301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Weber, K. S. C. Weber, C. Klier, S. Gu, R. Wank, R. Horuk, and P. J. Nelson Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+ T cells Blood, February 15, 2001; 97(4): 1144 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tyagi, L. B. Klickstein, and A. Nicholson-Weller C5a-stimulated human neutrophils use a subset of {beta}2 integrins to support the adhesion-dependent phase of superoxide production J. Leukoc. Biol., November 1, 2000; 68(5): 679 - 686. [Abstract] [Full Text]
|
|
|
|
|
|
N. Mozaffarian, A. Casadevall, and J. W. Berman Inhibition of Human Endothelial Cell Chemokine Production by the Opportunistic Fungal Pathogen Cryptococcus neoformans J. Immunol., August 1, 2000; 165(3): 1541 - 1547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. M. Soede, Y. M. Wijnands, M. Kamp, M. A. van der Valk, and E. Roos Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi Blood, July 15, 2000; 96(2): 691 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Liu, D. Calderwood, and M. Ginsberg Integrin cytoplasmic domain-binding proteins J. Cell Sci., January 10, 2000; 113(20): 3563 - 3571. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Ashida, H. Arai, M. Yamasaki, and T. Kita Distinct Signaling Pathways for MCP-1-dependent Integrin Activation and Chemotaxis J. Biol. Chem., May 4, 2001; 276(19): 16555 - 16560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Harris, T. M. McIntyre, S. M. Prescott, and G. A. Zimmerman The Leukocyte Integrins J. Biol. Chem., July 28, 2000; 275(31): 23409 - 23412. [Full Text] [PDF]
|
|
