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Vol. 10, Issue 5, 1511-1520, May 1999
Department of Physiology, Tufts University School of Medicine,
Boston, Massachusetts 02111
Immunocytochemistry and in vitro studies have suggested that the
ERM (ezrin-radixin-moesin) protein, radixin, may have a role in nerve
growth cone motility. We tested the in situ role of radixin in chick
dorsal root ganglion growth cones by observing the effects of
its localized and acute inactivation. Microscale chromophore-assisted laser inactivation (micro-CALI) of radixin in growth cones causes a
30% reduction of lamellipodial area within the irradiated region whereas all control treatments did not affect lamellipodia. Micro-CALI of radixin targeted to the middle of the leading edge often split growth cones to form two smaller growth cones during continued forward
movement (>80%). These findings suggest a critical role for radixin
in growth cone lamellipodia that is similar to ezrin function in
pseudopodia of transformed fibroblasts. They are consistent with
radixin linking actin filaments to each other or to the membrane during motility.
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