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Vol. 10, Issue 5, 1637-1652, May 1999
*Department of Biochemistry, We identified seven alternatively spliced forms of human
8-oxoguanine DNA glycosylase (OGG1) mRNAs, classified into two types based on their last exons (type 1 with exon 7: 1a and 1b; type 2 with
exon 8: 2a to 2e). Types 1a and 2a mRNAs are major in human tissues.
Seven mRNAs are expected to encode different polypeptides (OGG1-1a to
2e) that share their N terminus with the common mitochondrial targeting
signal, and each possesses a unique C terminus. A 36-kDa polypeptide,
corresponding to OGG1-1a recognized only by antibodies against the
region containing helix-hairpin-helix-PVD motif, was copurified from
the nuclear extract with an activity introducing a nick into DNA
containing 8-oxoguanine. A 40-kDa polypeptide corresponding to a
processed form of OGG1-2a was detected in their mitochondria using
antibodies against its C terminus. Electron microscopic
immunocytochemistry and subfractionation of the mitochondria revealed
that OGG1-2a locates on the inner membrane of mitochondria. Deletion
mutant analyses revealed that the unique C terminus of OGG1-2a and its
mitochondrial targeting signal are essential for mitochondrial
localization and that nuclear localization of OGG1-1a depends on the
NLS at its C terminus.
Department of Clinical Chemistry and Laboratory
Medicine,Department of Biochemistry, School of Medicine, Fukuoka
University, Fukuoka 814-0180, Japan
Corresponding author. E-mail address:
yusaku{at}bioreg.kyushu-u.ac.jp.
Molecular Biology of the Cell
Vol. 10, 1637-1652, May 1999
Copyright © 1999 by The American Society for Cell Biology
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