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Vol. 10, Issue 6, 1923-1938, June 1999


*Cell Biology Unit, Glaxo-Wellcome Research and Development,
Stevenage, Hertfordshire, SG1 2NY, United Kingdom;
Six new members of the yeast p24 family have been identified and
characterized. These six genes, named ERP1-ERP6 (for
Emp24p- and Erv25p-related proteins) are not essential, but deletion of ERP1 or ERP2 causes defects in the
transport of Gas1p, in the retention of BiP, and deletion of
ERP1 results in the suppression of a
temperature-sensitive mutation in SEC13 encoding a
COPII vesicle coat protein. These phenotypes are similar to
those caused by deletion of EMP24 or
ERV25, two previously identified genes that encode
related p24 proteins. Genetic and biochemical studies demonstrate that
Erp1p and Erp2p function in a heteromeric complex with Emp24p and Erv25p.
Department of Molecular and Cell Biology, Howard Hughes
Medical Institute, University of California, Berkeley, California
94720;
Biotechnology Research Institute, National
Research Council of Canada, Montreal, Quebec, Canada H4P 2R2; and
§Department of Anatomy and Cell Biology, McGill
University, Montreal, Quebec, Canada H3A 2B2
Corresponding author. E-mail address:
ar14034{at}glaxowellcome.co.uk.
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