![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 10, Issue 8, 2573-2582, August 1999
and
*School of Biological Sciences, University of Manchester,
Manchester, M13 9PT, United Kingdom; ERp57 is a lumenal protein of the endoplasmic reticulum (ER) and a
member of the protein disulfide isomerase (PDI) family. In contrast to
archetypal PDI, ERp57 interacts specifically with newly synthesized
glycoproteins. In this study we demonstrate that ERp57 forms discrete
complexes with the ER lectins, calnexin and calreticulin. Specific
ERp57/calreticulin complexes exist in canine pancreatic microsomes, as
demonstrated by SDS-PAGE after cross-linking, and by native
electrophoresis in the absence of cross-linking. After in vitro
translation and import into microsomes, radiolabeled ERp57 can be
cross-linked to endogenous calreticulin and calnexin while radiolabeled
PDI cannot. Likewise, radiolabeled calreticulin is cross-linked to
endogenous ERp57 but not PDI. Similar results were obtained in Lec23
cells, which lack the glucosidase I necessary to produce glycoprotein
substrates capable of binding to calnexin and calreticulin. This
observation indicates that ERp57 interacts with both of the ER lectins
in the absence of their glycoprotein substrate. This result was
confirmed by a specific interaction between in vitro synthesized
calreticulin and ERp57 prepared in solution in the absence of other ER
components. We conclude that ERp57 forms complexes with both calnexin
and calreticulin and propose that it is these complexes that can
specifically modulate glycoprotein folding within the ER lumen.
Department of
Physiology, University of Texas Health Science Center, San Antonio,
Texas 78284; and Department of Medical
Biochemistry, University of Wales College of Medicine, Heath Park,
Cardiff, CF4 4XN, United Kingdom
This article has been cited by other articles:
|
|
 |
|
  N. Del Cid, E. Jeffery, S. M. Rizvi, E. Stamper, L. R. Peters, W. C. Brown, C. Provoda, and M. Raghavan Modes of Calreticulin Recruitment to the Major Histocompatibility Complex Class I Assembly Pathway J. Biol. Chem., February 12, 2010; 285(7): 4520 - 4535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-a. Kawano, L. Xing, H. Tsukamoto, T. Inoue, H. Handa, and R. H. Cheng Calcium Bridge Triggers Capsid Disassembly in the Cell Entry Process of Simian Virus 40 J. Biol. Chem., December 11, 2009; 284(50): 34703 - 34712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. S. Yang, N. Y. Harel, and S. M. Strittmatter Reticulon-4A (Nogo-A) Redistributes Protein Disulfide Isomerase to Protect Mice from SOD1-Dependent Amyotrophic Lateral Sclerosis J. Neurosci., November 4, 2009; 29(44): 13850 - 13859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Matsuo, H. Masutani, A. Son, S. Kizaka-Kondoh, and J. Yodoi Physical and Functional Interaction of Transmembrane Thioredoxin-related Protein with Major Histocompatibility Complex Class I Heavy Chain: Redox-based Protein Quality Control and Its Potential Relevance to Immune Responses Mol. Biol. Cell, November 1, 2009; 20(21): 4552 - 4562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Schulz, C. U. Stirnimann, J. P. A. Grimshaw, M. S. Brozzo, F. Fritsch, E. Mohorko, G. Capitani, R. Glockshuber, M. G. Grutter, and M. Aebi Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency PNAS, July 7, 2009; 106(27): 11061 - 11066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Xu, R. E. Perez, M. H. Rezaiekhaligh, M. Bourdi, and W. E. Truog Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis Am J Physiol Lung Cell Mol Physiol, July 1, 2009; 297(1): L44 - L51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Doolittle, O. Ben-Zeev, S. Bassilian, J. P. Whitelegge, M. Peterfy, and H. Wong Hepatic lipase maturation: a partial proteome of interacting factors J. Lipid Res., June 1, 2009; 50(6): 1173 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Jessop, T. J. Tavender, R. H. Watkins, J. E. Chambers, and N. J. Bulleid Substrate Specificity of the Oxidoreductase ERp57 Is Determined Primarily by Its Interaction with Calnexin and Calreticulin J. Biol. Chem., January 23, 2009; 284(4): 2194 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Verweij, D. Koppers-Lalic, S. Loch, F. Klauschies, H. de la Salle, E. Quinten, P. J. Lehner, A. Mulder, M. R. Knittler, R. Tampe, et al. The Varicellovirus UL49.5 Protein Blocks the Transporter Associated with Antigen Processing (TAP) by Inhibiting Essential Conformational Transitions in the 6+6 Transmembrane TAP Core Complex J. Immunol., October 1, 2008; 181(7): 4894 - 4907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Hebert and M. Molinari In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases Physiol Rev, October 1, 2007; 87(4): 1377 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Nawa, O. Shimada, N. Kawasaki, N. Matsumoto, and K. Yamamoto Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP Glycobiology, September 1, 2007; 17(9): 913 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Mondotte, P.-Y. Lozach, A. Amara, and A. V. Gamarnik Essential Role of Dengue Virus Envelope Protein N Glycosylation at Asparagine-67 during Viral Propagation J. Virol., July 1, 2007; 81(13): 7136 - 7148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Santos, E. C. Campbell, S. Lynch, V. Wong, A. N. Antoniou, and S. J. Powis Major Histocompatibility Complex Class I-ERp57-Tapasin Interactions within the Peptide-loading Complex J. Biol. Chem., June 15, 2007; 282(24): 17587 - 17593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. I. Alanen, R. A. Williamson, M. J. Howard, F. S. Hatahet, K. E. H. Salo, A. Kauppila, S. Kellokumpu, and L. W. Ruddock ERp27, a New Non-catalytic Endoplasmic Reticulum-located Human Protein Disulfide Isomerase Family Member, Interacts with ERp57 J. Biol. Chem., November 3, 2006; 281(44): 33727 - 33738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, E. Baig, and D. B. Williams Functions of ERp57 in the Folding and Assembly of Major Histocompatibility Complex Class I Molecules J. Biol. Chem., May 26, 2006; 281(21): 14622 - 14631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Martin, J. Groenendyk, S. S. Steiner, L. Guo, M. Dabrowska, J. M. R. Parker, W. Muller-Esterl, M. Opas, and M. Michalak Identification by Mutational Analysis of Amino Acid Residues Essential in the Chaperone Function of Calreticulin J. Biol. Chem., January 27, 2006; 281(4): 2338 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Kulp, E.-M. Frickel, L. Ellgaard, and J. S. Weissman Domain Architecture of Protein-disulfide Isomerase Facilitates Its Dual Role as an Oxidase and an Isomerase in Ero1p-mediated Disulfide Formation J. Biol. Chem., January 13, 2006; 281(2): 876 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Di Jeso, Y.-n. Park, L. Ulianich, A. S. Treglia, M. L. Urbanas, S. High, and P. Arvan Mixed-Disulfide Folding Intermediates between Thyroglobulin and Endoplasmic Reticulum Resident Oxidoreductases ERp57 and Protein Disulfide Isomerase Mol. Cell. Biol., November 15, 2005; 25(22): 9793 - 9805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kimura, Y. Hosoda, Y. Sato, Y. Kitamura, T. Ikeda, T. Horibe, and M. Kikuchi Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities J. Biol. Chem., September 9, 2005; 280(36): 31438 - 31441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, R. Daniels, and D. N. Hebert The Cotranslational Maturation of the Type I Membrane Glycoprotein Tyrosinase: The Heat Shock Protein 70 System Hands Off to the Lectin-based Chaperone System Mol. Biol. Cell, August 1, 2005; 16(8): 3740 - 3752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhu, J. Peng, D. Chen, X. Liu, L. Ye, H. Iijima, K. Kadavil, W. I. Lencer, and R. S. Blumberg Calnexin and ERp57 Facilitate the Assembly of the Neonatal Fc Receptor for IgG with {beta}2-Microglobulin in the Endoplasmic Reticulum J. Immunol., July 15, 2005; 175(2): 967 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hong, S. Sundaram, D.-J. Shin, and P. Stanley The Lec23 Chinese Hamster Ovary Mutant Is a Sensitive Host for Detecting Mutations in {alpha}-Glucosidase I That Give Rise to Congenital Disorder of Glycosylation IIb (CDG IIb) J. Biol. Chem., November 26, 2004; 279(48): 49894 - 49901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chakravarthi and N. J. Bulleid Glutathione Is Required to Regulate the Formation of Native Disulfide Bonds within Proteins Entering the Secretory Pathway J. Biol. Chem., September 17, 2004; 279(38): 39872 - 39879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bertoli, T. Simmen, T. Anelli, S. N. Molteni, R. Fesce, and R. Sitia Two Conserved Cysteine Triads in Human Ero1{alpha} Cooperate for Efficient Disulfide Bond Formation in the Endoplasmic Reticulum J. Biol. Chem., July 16, 2004; 279(29): 30047 - 30052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mizrachi and D. L. Segaloff Intracellularly Located Misfolded Glycoprotein Hormone Receptors Associate with Different Chaperone Proteins than Their Cognate Wild-Type Receptors Mol. Endocrinol., July 1, 2004; 18(7): 1768 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Wearsch, C. A. Jakob, A. Vallin, R. A. Dwek, P. M. Rudd, and P. Cresswell Major Histocompatibility Complex Class I Molecules Expressed with Monoglucosylated N-Linked Glycans Bind Calreticulin Independently of Their Assembly Status J. Biol. Chem., June 11, 2004; 279(24): 25112 - 25121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Frenkel, M. Shenkman, M. Kondratyev, and G. Z. Lederkremer Separate Roles and Different Routing of Calnexin and ERp57 in Endoplasmic Reticulum Quality Control Revealed by Interactions with Asialoglycoprotein Receptor Chains Mol. Biol. Cell, May 1, 2004; 15(5): 2133 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-M. Frickel, P. Frei, M. Bouvier, W. F. Stafford, A. Helenius, R. Glockshuber, and L. Ellgaard ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase J. Biol. Chem., April 30, 2004; 279(18): 18277 - 18287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Russell, L. W. Ruddock, K. E. H. Salo, J. D. Oliver, Q. P. Roebuck, D. H. Llewellyn, H. L. Roderick, P. Koivunen, J. Myllyharju, and S. High The Primary Substrate Binding Site in the b' Domain of ERp57 Is Adapted for Endoplasmic Reticulum Lectin Association J. Biol. Chem., April 30, 2004; 279(18): 18861 - 18869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Silvennoinen, J. Myllyharju, M. Ruoppolo, S. Orru, M. Caterino, K. I. Kivirikko, and P. Koivunen Identification and Characterization of Structural Domains of Human ERp57: ASSOCIATION WITH CALRETICULIN REQUIRES SEVERAL DOMAINS J. Biol. Chem., April 2, 2004; 279(14): 13607 - 13615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Antoniou, S. Ford, J. D. Taurog, G. W. Butcher, and S. J. Powis Formation of HLA-B27 Homodimers and Their Relationship to Assembly Kinetics J. Biol. Chem., March 5, 2004; 279(10): 8895 - 8902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li and P. Camacho Ca2+-dependent redox modulation of SERCA 2b by ERp57 J. Cell Biol., January 5, 2004; 164(1): 35 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Knoblach, B. O. Keller, J. Groenendyk, S. Aldred, J. Zheng, B. D. Lemire, L. Li, and M. Michalak ERp19 and ERp46, New Members of the Thioredoxin Family of Endoplasmic Reticulum Proteins Mol. Cell. Proteomics, October 1, 2003; 2(10): 1104 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Trombetta The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis Glycobiology, September 1, 2003; 13(9): 77R - 91R. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Conte, C. Labriola, J. J. Cazzulo, R. Docampo, and A. J. Parodi The Interplay between Folding-facilitating Mechanisms in Trypanosoma cruzi Endoplasmic Reticulum Mol. Biol. Cell, September 1, 2003; 14(9): 3529 - 3540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. P. Eschenlauer and A. P. Page The Caenorhabditis elegans ERp60 Homolog Protein Disulfide Isomerase-3 Has Disulfide Isomerase and Transglutaminase-like Cross-linking Activity and Is Involved in the Maintenance of Body Morphology J. Biol. Chem., January 31, 2003; 278(6): 4227 - 4237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hosoda, Y. Kimata, A. Tsuru, and K. Kohno JPDI, a Novel Endoplasmic Reticulum-resident Protein Containing Both a BiP-interacting J-domain and Thioredoxin-like Motifs J. Biol. Chem., January 17, 2003; 278(4): 2669 - 2676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Jeffers, D. A. Sanders, and A. Sanchez Covalent Modifications of the Ebola Virus Glycoprotein J. Virol., December 15, 2002; 76(24): 12463 - 12472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Meunier, Y.-K. Usherwood, K. T. Chung, and L. M. Hendershot A Subset of Chaperones and Folding Enzymes Form Multiprotein Complexes in Endoplasmic Reticulum to Bind Nascent Proteins Mol. Biol. Cell, December 1, 2002; 13(12): 4456 - 4469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Radcliffe, G. Diedrich, D. J. Harvey, R. A. Dwek, P. Cresswell, and P. M. Rudd Identification of Specific Glycoforms of Major Histocompatibility Complex Class I Heavy Chains Suggests That Class I Peptide Loading Is an Adaptation of the Quality Control Pathway Involving Calreticulin and ERp57 J. Biol. Chem., November 22, 2002; 277(48): 46415 - 46423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Kang and P. Cresswell Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain J. Biol. Chem., November 15, 2002; 277(47): 44838 - 44844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Leach, M. F. Cohen-Doyle, D. Y. Thomas, and D. B. Williams Localization of the Lectin, ERp57 Binding, and Polypeptide Binding Sites of Calnexin and Calreticulin J. Biol. Chem., August 9, 2002; 277(33): 29686 - 29697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Dangoria, M. L. DeLay, D. J. Kingsbury, J. P. Mear, B. Uchanska-Ziegler, A. Ziegler, and R. A. Colbert HLA-B27 Misfolding Is Associated with Aberrant Intermolecular Disulfide Bond Formation (Dimerization) in the Endoplasmic Reticulum J. Biol. Chem., June 21, 2002; 277(26): 23459 - 23468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Paulsson, M. J. Kleijmeer, J. Griffith, M. Jevon, S. Chen, P. O. Anderson, H.-O. Sjogren, S. Li, and P. Wang Association of Tapasin and COPI Provides a Mechanism for the Retrograde Transport of Major Histocompatibility Complex (MHC) Class I Molecules from the Golgi Complex to the Endoplasmic Reticulum J. Biol. Chem., May 17, 2002; 277(21): 18266 - 18271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bolt, K. Berg, and M. Blixenkrone-Moller Measles virus-induced modulation of host-cell gene expression J. Gen. Virol., May 1, 2002; 83(5): 1157 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ellgaard, R. Riek, T. Herrmann, P. Güntert, D. Braun, A. Helenius, and K. Wüthrich NMR structure of the calreticulin P-domain PNAS, March 1, 2001; (2001) 51630098. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Farmery, S. Allen, A. J. Allen, and N. J. Bulleid The Role of ERp57 in Disulfide Bond Formation during the Assembly of Major Histocompatibility Complex Class I in a Synchronized Semipermeabilized Cell Translation System J. Biol. Chem., May 12, 2000; 275(20): 14933 - 14938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ellgaard, M. Molinari, and A. Helenius Setting the Standards: Quality Control in the Secretory Pathway Science, December 3, 1999; 286(5446): 1882 - 1888. [Abstract] [Full Text]
|
|
|
|
|
|
A. Pirneskoski, L. W. Ruddock, P. Klappa, R. B. Freedman, K. I. Kivirikko, and P. Koivunen Domains b' and a' of Protein Disulfide Isomerase Fulfill the Minimum Requirement for Function as a Subunit of Prolyl 4-Hydroxylase. THE N-TERMINAL DOMAINS a AND b ENHANCE THIS FUNCTION AND CAN BE SUBSTITUTED IN PART BY THOSE OF ERp57 J. Biol. Chem., March 30, 2001; 276(14): 11287 - 11293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Johnson and B. Mook-Kanamori Dependence of Elevated Human Leukocyte Antigen Class I Molecule Expression on Increased Heavy Chain, Light Chain (beta 2-Microglobulin), Transporter Associated with Antigen Processing, Tapasin, and Peptide J. Biol. Chem., May 26, 2000; 275(22): 16643 - 16649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-M. Frickel, R. Riek, I. Jelesarov, A. Helenius, K. Wuthrich, and L. Ellgaard TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain PNAS, February 19, 2002; 99(4): 1954 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ellgaard, R. Riek, T. Herrmann, P. Guntert, D. Braun, A. Helenius, and K. Wuthrich NMR structure of the calreticulin P-domain PNAS, March 13, 2001; 98(6): 3133 - 3138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Wyse, N. Ali, and D. H. Ellison Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter Am J Physiol Renal Physiol, March 1, 2002; 282(3): F424 - F430. [Abstract] [Full Text] [PDF]
|
|
