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Vol. 10, Issue 8, 2703-2734, August 1999
Laboratory of Molecular Pharmacology, Division of Basic Sciences,
National Cancer Institute, Bethesda, Maryland 20892
Eventually to understand the integrated function of the cell cycle
regulatory network, we must organize the known interactions in the form
of a diagram, map, and/or database. A diagram convention was designed
capable of unambiguous representation of networks containing
multiprotein complexes, protein modifications, and enzymes that are
substrates of other enzymes. To facilitate linkage to a database, each
molecular species is symbolically represented only once in each
diagram. Molecular species can be located on the map by means of
indexed grid coordinates. Each interaction is referenced to an
annotation list where pertinent information and references can be
found. Parts of the network are grouped into functional subsystems. The
map shows how multiprotein complexes could assemble and function at
gene promoter sites and at sites of DNA damage. It also portrays the
richness of connections between the p53-Mdm2 subsystem and other parts
of the network.
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