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Vol. 10, Issue 8, 2735-2743, August 1999
Department of Molecular and Cellular Biology & Biochemistry, Brown
University, Providence, Rhode Island 02912
We recently identified a single family member homologue of syntaxin
in the sea urchin. Syntaxin is present throughout development, and in
rapidly dividing cleavage stage embryos it is present on numerous
vesicles at the cell cortex. We hypothesized that syntaxin mediates
essential membrane fusion events during early embryogenesis, reasoning
that the vesicles and/or their contents are important for development.
Here we show that functional inactivation of syntaxin with either
Botulinum neurotoxin C1, which specifically proteolyzes
syntaxin, or antibodies against syntaxin results in an inhibition of
cell division. These observations suggest that syntaxin is essential
for membrane fusion events critical for cell division.
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