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Vol. 11, Issue 1, 369-391, January 2000
and
*Department of Biology, Virginia Polytechnic Institute and State
University, Blacksburg Virginia 24061; and The molecular machinery of cell cycle control is known in more
detail for budding yeast, Saccharomyces cerevisiae, than
for any other eukaryotic organism. In recent years, many elegant
experiments on budding yeast have dissected the roles of cyclin
molecules (Cln1-3 and Clb1-6) in coordinating the events of DNA
synthesis, bud emergence, spindle formation, nuclear division, and cell
separation. These experimental clues suggest a mechanism for the
principal molecular interactions controlling cyclin synthesis and
degradation. Using standard techniques of biochemical kinetics, we
convert the mechanism into a set of differential equations, which
describe the time courses of three major classes of cyclin-dependent
kinase activities. Model in hand, we examine the molecular events
controlling "Start" (the commitment step to a new round of
chromosome replication, bud formation, and mitosis) and "Finish"
(the transition from metaphase to anaphase, when sister chromatids are
pulled apart and the bud separates from the mother cell) in wild-type
cells and 50 mutants. The model accounts for many details of the
physiology, biochemistry, and genetics of cell cycle control in budding yeast.
Department of
Agricultural Chemical Technology, Technical University of Budapest,
Gellert Ter 4, H-1521 Budapest, Hungary
Corresponding author. E-mail address:
tyson{at}vt.edu.
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