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Vol. 11, Issue 10, 3485-3494, October 2000
§
*Group of Cellular Biology of Tumoral Immunity, Institut National
de la Santé et de la Recherche Médicale U520, Institut
Curie, F-75248 Paris Cédex 05, France; Soluble N-ethyl maleimide-sensitive fusion protein
attachment protein receptors (SNAREs) are core machinery for membrane
fusion during intracellular vesicular transport. Synaptosome-associated protein of 23 kDa (SNAP23) is a target SNARE previously identified at
the plasma membrane, where it is involved in exocytotic membrane fusion. Here we show that SNAP23 associates with vimentin filaments in
a Triton X-100 insoluble fraction in fibroblasts in primary culture and
HeLa cells. Upon treatment of human fibroblasts with N-ethyl-maleimide, SNAP23 dissociates from vimentin
filaments and forms a protein complex with syntaxin 4, a plasma
membrane SNARE. The vimentin-associated pool of SNAP23 can therefore be a reservoir, which would supply the plasma membrane fusion machinery, in fibroblasts. Our observation points to a yet unexplored role of
intermediate filaments.
Group of
Membrane Traffic and Neuronal Plasticity, Institut National de la
Santé et de la Recherche Médicale U536, Institut Curie,
F-75248 Paris Cédex 05, France; §Group of
Morphogenesis and Cell Signalling, Centre National de la Recherche
Scientifique Unite Mixte de Recherche 144, Institut Curie, F-75248
Paris Cédex 05, France; and Unité de Biologie
du Développement, Institut Pasteur, Centre National de la
Recherche Scientifique Unité de Recherche Associée 1960, 75724 Paris Cédex 15, France
Corresponding author: E-mail address:
thierry.galli{at}curie.fr.
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