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Vol. 11, Issue 2, 543-554, February 2000
Instituto de Microbiología Bioquímica, Departamento
de Microbiología y Genética, Consejo Superior de
Investigaciones Científicas/Universidad de Salamanca, 37007 Salamanca, Spain
Eukaryotic cells coordinate cell size with cell division by
regulating the length of the G1 and G2 phases of the cell cycle. In
fission yeast, the length of the G1 phase depends on a precise balance
between levels of positive (cig1, cig2, puc1, and cdc13 cyclins) and
negative (rum1 and ste9-APC) regulators of cdc2. Early in G1, cyclin
proteolysis and rum1 inhibition keep the cdc2/cyclin complexes
inactive. At the end of G1, the balance is reversed and cdc2/cyclin
activity down-regulates both rum1 and the cyclin-degrading activity of
the APC. Here we present data showing that the puc1 cyclin, a close
relative of the Cln cyclins in budding yeast, plays an important role
in regulating the length of G1. Fission yeast cells lacking cig1 and
cig2 have a cell cycle distribution similar to that of wild-type cells,
with a short G1 and a long G2. However, when the
puc1+ gene is deleted in this genetic
background, the length of G1 is extended and these cells undergo S
phase with a greater cell size than wild-type cells. This G1 delay is
completely abolished in cells lacking rum1. Cdc2/puc1 function may be
important to down-regulate the rum1 Cdk inhibitor at the end of G1.
Corresponding author. E-mail address:
smo{at}gugu.usal.es.
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