![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 11, Issue 4, 1169-1181, April 2000
Section of Microbiology, University of California, Davis,
California 95616
In response to oxidative stress, eukaryotic cells induce
transcription of genes required for detoxification of oxidants. Here we
present evidence that oxidative stress stimuli are transmitted by a
multistep phosphorelay system to the Spc1/Sty1
stress-activated protein kinase in the fission yeast
Schizosaccharomyces pombe. The fission yeast
mpr1+ gene encodes a novel protein with a
histidine-containing phosphotransfer domain homologous to the budding
yeast Ypd1. Spc1 activation upon oxidative stress is severely impaired
in the 
mpr1 mutant as well as in the
mpr1HQ strain, in which the putative phosphorylation site Mpr1-His221 is substituted with glutamine. In response to oxidative stress, Mpr1 binds to the Mcs4 response regulator that functions upstream of the Spc1 cascade, suggesting that Mcs4 is a
cognate response regulator for Mpr1. Unexpectedly, when exposed to
hydrogen peroxide, mpr1 cells can induce the catalase
gene ctt1+, one of the transcriptional
targets of the Spc1 pathway, and survive oxidative stress in the
absence of significant Spc1 activation. We have found that Pap1, a bZIP
transcription factor homologous to human c-Jun, can mediate induction
of ctt1+ expression upon oxidative stress
independently of the Spc1 stress-activated protein kinase. These
studies show that oxidative stress stimuli are transmitted by multiple
pathways to induce specific gene expression.
This article has been cited by other articles:
|
|
 |
|
  M. Sanso, M. Gogol, J. Ayte, C. Seidel, and E. Hidalgo Transcription Factors Pcr1 and Atf1 Have Distinct Roles in Stress- and Sty1-Dependent Gene Regulation Eukaryot. Cell, May 1, 2008; 7(5): 826 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chen, C. R.M. Wilkinson, S. Watt, C. J. Penkett, W. M. Toone, N. Jones, and J. Bahler Multiple Pathways Differentially Regulate Global Oxidative Stress Responses in Fission Yeast Mol. Biol. Cell, January 1, 2008; 19(1): 308 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Vargas-Perez, O. Sanchez, L. Kawasaki, D. Georgellis, and J. Aguirre Response Regulators SrrA and SskA Are Central Components of a Phosphorelay System Involved in Stress Signal Transduction and Asexual Sporulation in Aspergillus nidulans Eukaryot. Cell, September 1, 2007; 6(9): 1570 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Lawrence, H. Maekawa, J. L. Worthington, W. Reiter, C. R. M. Wilkinson, and N. Jones Regulation of Schizosaccharomyces pombe Atf1 Protein Levels by Sty1-mediated Phosphorylation and Heterodimerization with Pcr1 J. Biol. Chem., February 23, 2007; 282(8): 5160 - 5170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Georgiou, N. Patsoukis, I. Papapostolou, and G. Zervoudakis Sclerotial metamorphosis in filamentous fungi is induced by oxidative stress Integr. Comp. Biol., December 1, 2006; 46(6): 691 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takatsume, S. Izawa, and Y. Inoue Methylglyoxal as a Signal Initiator for Activation of the Stress-activated Protein Kinase Cascade in the Fission Yeast Schizosaccharomyces pombe J. Biol. Chem., April 7, 2006; 281(14): 9086 - 9092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Martin, M. A. Rodriguez-Gabriel, W. H. McDonald, S. Watt, J. R. Yates III, J. Bahler, and P. Russell Cip1 and Cip2 Are Novel RNA-Recognition-Motif Proteins That Counteract Csx1 Function during Oxidative Stress Mol. Biol. Cell, March 1, 2006; 17(3): 1176 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dunand-Sauthier, C. A. Walker, J. Narasimhan, A. K. Pearce, R. C. Wek, and T. C. Humphrey Stress-Activated Protein Kinase Pathway Functions To Support Protein Synthesis and Translational Adaptation in Response to Environmental Stress in Fission Yeast Eukaryot. Cell, November 1, 2005; 4(11): 1785 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Rodriguez-Gabriel and P. Russell Distinct Signaling Pathways Respond to Arsenite and Reactive Oxygen Species in Schizosaccharomyces pombe Eukaryot. Cell, August 1, 2005; 4(8): 1396 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Davidson, H. K. Shandilya, K. Hirota, K. Ohta, and W. P. Wahls Atf1-Pcr1-M26 Complex Links Stress-activated MAPK and cAMP-dependent Protein Kinase Pathways via Chromatin Remodeling of cgs2+ J. Biol. Chem., December 3, 2004; 279(49): 50857 - 50863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Zhan, J. Narasimhan, and R. C. Wek Differential Activation of eIF2 Kinases in Response to Cellular Stresses in Schizosaccharomyces pombe Genetics, December 1, 2004; 168(4): 1867 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Madrid, T. Soto, A. Franco, V. Paredes, J. Vicente, E. Hidalgo, M. Gacto, and J. Cansado A Cooperative Role for Atf1 and Pap1 in the Detoxification of the Oxidative Stress Induced by Glucose Deprivation in Schizosaccharomyces pombe J. Biol. Chem., October 1, 2004; 279(40): 41594 - 41602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watson, J. Mata, J. Bahler, A. Carr, and T. Humphrey Global Gene Expression Responses of Fission Yeast to Ionizing Radiation Mol. Biol. Cell, February 1, 2004; 15(2): 851 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Castillo, A. P. Vivancos, N. Jones, J. Ayte, and E. Hidalgo Schizosaccharomyces pombe Cells Lacking the Ran-binding Protein Hba1 Show a Multidrug Resistance Phenotype Due to Constitutive Nuclear Accumulation of Pap1 J. Biol. Chem., October 17, 2003; 278(42): 40565 - 40572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tatebe and K. Shiozaki Identification of Cdc37 as a Novel Regulator of the Stress-Responsive Mitogen-Activated Protein Kinase Mol. Cell. Biol., August 1, 2003; 23(15): 5132 - 5142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Moye-Rowley Regulation of the Transcriptional Response to Oxidative Stress in Fungi: Similarities and Differences Eukaryot. Cell, June 1, 2003; 2(3): 381 - 389. [Full Text] [PDF]
|
|
|
|
|
|
D. Chen, W. M. Toone, J. Mata, R. Lyne, G. Burns, K. Kivinen, A. Brazma, N. Jones, and J. Bahler Global Transcriptional Responses of Fission Yeast to Environmental Stress Mol. Biol. Cell, January 1, 2003; 14(1): 214 - 229. [Abstract] [Full Text]
|
|
|
|
|
|
K. Zhan, K. M. Vattem, B. N. Bauer, T. E. Dever, J.-J. Chen, and R. C. Wek Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses Mol. Cell. Biol., October 15, 2002; 22(20): 7134 - 7146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Greenall, A. P. Hadcroft, P. Malakasi, N. Jones, B. A. Morgan, C. S. Hoffman, and S. K. Whitehall Role of Fission Yeast Tup1-like Repressors and Prr1 Transcription Factor in Response to Salt Stress Mol. Biol. Cell, September 1, 2002; 13(9): 2977 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Smith, W. M. Toone, D. Chen, J. Bahler, N. Jones, B. A. Morgan, and J. Quinn The Srk1 Protein Kinase Is a Target for the Sty1 Stress-activated MAPK in Fission Yeast J. Biol. Chem., August 30, 2002; 277(36): 33411 - 33421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hohmann Osmotic Stress Signaling and Osmoadaptation in Yeasts Microbiol. Mol. Biol. Rev., June 1, 2002; 66(2): 300 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sanchez-Piris, F. Posas, V. Alemany, I. Winge, E. Hidalgo, O. Bachs, and R. Aligue The Serine/Threonine Kinase Cmk2 Is Required for Oxidative Stress Response in Fission Yeast J. Biol. Chem., May 10, 2002; 277(20): 17722 - 17727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Mizuno, T. Hasemi, T. Ubukata, T. Yamada, E. Lehmann, J. Kohli, Y. Watanabe, Y. Iino, M. Yamamoto, M. E. Fox, et al. Counteracting Regulation of Chromatin Remodeling at a Fission Yeast cAMP Responsive Element-Related Recombination Hotspot by Stress-Activated Protein Kinase, cAMP-Dependent Kinase and Meiosis Regulators Genetics, December 1, 2001; 159(4): 1467 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Santos and K. Shiozaki Fungal Histidine Kinases Sci. Signal., September 4, 2001; 2001(98): re1 - re1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Buck, J. Quinn, T. S. Pino, H. Martin, J. Saldanha, K. Makino, B. A. Morgan, and J. B.A. Millar Peroxide Sensors for the Fission Yeast Stress-activated Mitogen-activated Protein Kinase Pathway Mol. Biol. Cell, February 1, 2001; 12(2): 407 - 419. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Aoyama, Y. Mitsubayashi, H. Aiba, and T. Mizuno Spy1, a Histidine-Containing Phosphotransfer Signaling Protein, Regulates the Fission Yeast Cell Cycle through the Mcs4 Response Regulator J. Bacteriol., September 1, 2000; 182(17): 4868 - 4874. [Abstract] [Full Text]
|
|
|
|
 |
|
 P Thomason and R Kay Eukaryotic signal transduction via histidine-aspartate phosphorelay J. Cell Sci., January 9, 2000; 113(18): 3141 - 3150. [Abstract] [PDF]
|
|
