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Vol. 11, Issue 4, 1305-1313, April 2000
Department of Molecular and Cellular Biology, Baylor College of
Medicine, Houston, Texas 77030
This work describes BRN1, the budding yeast
homologue of Drosophila Barren and
Xenopus condensin subunit XCAP-H. The
Drosophila protein is required for proper chromosome
segregation in mitosis, and Xenopus protein functions in
mitotic chromosome condensation. Mutant brn1 cells show
a defect in mitotic chromosome condensation and sister chromatid
separation and segregation in anaphase. Chromatid cohesion before
anaphase is properly maintained in the mutants. Some
brn1 mutant cells apparently arrest in S-phase, pointing to a possible function for Brn1p at this stage of the cell cycle. Brn1p
is a nuclear protein with a nonuniform distribution pattern, and its
level is up-regulated at mitosis. Temperature-sensitive mutations of
BRN1 can be suppressed by overexpression of a novel gene
YCG1, which is homologous to another
Xenopus condensin subunit, XCAP-G. Overexpression of
SMC2, a gene necessary for chromosome condensation, and a homologue of the XCAP-E condensin, does not suppress brn1, pointing to functional specialization of
components of the condensin complex.
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