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Vol. 11, Issue 5, 1571-1584, May 2000
*Department of Cell Biology, University of Massachusetts
Medical School, Worcester, Massachusetts 01655; Fertilization occurs after the completion of the sperm acrosome
reaction, a secretory event that is triggered during gamete adhesion.
ZP3, an egg zona pellucida glycoprotein, produces a sustained increase
of the internal Ca2+ concentration in mouse sperm, leading
to acrosome reactions. Here we show that the sustained Ca2+
concentration increase is due to the persistent activation of a
Ca2+ influx mechanism during the late stages of ZP3 signal
transduction. These cells also possess a Ca2+ store
depletion-activated Ca2+ entry pathway that is open after
treatment with thapsigargin. Thapsigargin and ZP3 activate the same
Ca2+ permeation mechanism, as demonstrated by fluorescence
quenching experiments and by channel antagonists. These studies show
that ZP3 generates a sustained Ca2+ influx through a store
depletion-operated pathway and that this drives the exocytotic
acrosome reaction.
Centre
d'Etudes de Grenoble, Departement de Biologie Moleculaire et
Structurale, 38054 Grenoble, France; Department
Genètica y Fisiologìa Molecular, Instituto d
Biotecnologia, Cuernavaca, Morelos 62210, Mèxico; and
§Department of Molecular and Cell Biology, University of
California, Berkeley, California 94720
Corresponding author. E-mail
address: harvey.florman{at}umassmed.edu.
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