![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 11, Issue 5, 1845-1858, May 2000
§
*Institut National de la Santé et de la Recherche
Médicale U-390, CHU Arnaud de Villeneuve, Montpellier,
34295 France; §Centre de Recherches de Biochimie
Macromoléculaire, Centre National de la Recherche Scientifique
UPR 1086, Montpellier, 34293 France; The signaling role of the Ca2+ releaser
inositol 1,4,5-trisphosphate (IP3) has been
associated with diverse cell functions. Yet, the physiological
significance of IP3 in tissues that feature a
ryanodine-sensitive sarcoplasmic reticulum has remained elusive. IP3 generated by photolysis of caged IP3 or by
purinergic activation of phospholipase CDivision of
Cardiovascular Diseases, Department of Medicine and Molecular
Pharmacology, Mayo Clinic, Rochester, Minnesota 55905; and
Department of Physiology, Centre Médical
Universitaire, Genève, Switzerland
slowed down or
abolished autonomic Ca2+ spiking in neonatal rat
cardiomyocytes. Microinjection of heparin, blocking dominant-negative
fusion protein, or anti-phospholipase C antibody prevented the
IP3-mediated purinergic effect. IP3 triggered a
ryanodine- and caffeine-insensitive Ca2+ release restricted
to the perinuclear region. In cells loaded with Rhod2 or expressing a
mitochondria-targeted cameleon and TMRM to monitor mitochondrial
Ca2+ and potential, IP3 induced transient
Ca2+ loading and depolarization of the organelles. These
mitochondrial changes were associated with Ca2+ depletion
of the sarcoplasmic reticulum and preceded the arrest of cellular
Ca2+ spiking. Thus, IP3 acting within a
restricted cellular region regulates the dynamic of calcium flow
between mitochondria and the endoplasmic/sarcoplasmic reticulum. We
have thus uncovered a novel role for IP3 in excitable
cells, the regulation of cardiac autonomic activity.
Corresponding author. E-mail address:
puceat{at}crbm.cnrs-mop.fr.
¶
Present address: Departement de Geriatrie, Centre
Médical Universitaire, Geneva, Switzerland.
#
Present address: Division of Biochemistry,
University of Tasmania, Hobart, Australia.
This article has been cited by other articles:
|
|
 |
|
  J. Satin, I. Itzhaki, S. Rapoport, E. A. Schroder, L. Izu, G. Arbel, R. Beyar, C. W. Balke, J. Schiller, and L. Gepstein Calcium Handling in Human Embryonic Stem Cell-Derived Cardiomyocytes Stem Cells, August 1, 2008; 26(8): 1961 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kapur and K. Banach Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes J. Physiol., June 15, 2007; 581(3): 1113 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, M. Stouffs, L. Serrander, B. Banfi, E. Bettiol, Y. Charnay, K. Steger, K.-H. Krause, and M. E. Jaconi The NADPH Oxidase NOX4 Drives Cardiac Differentiation: Role in Regulating Cardiac Transcription Factors and MAP Kinase Activation Mol. Biol. Cell, September 1, 2006; 17(9): 3978 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Miyamoto, A. L. Howes, J. W. Adams, G. W. Dorn II, and J. H. Brown Ca2+ Dysregulation Induces Mitochondrial Depolarization and Apoptosis: ROLE OF Na+/Ca2+ EXCHANGER AND AKT J. Biol. Chem., November 18, 2005; 280(46): 38505 - 38512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fauconnier, J. T. Lanner, S.-J. Zhang, P. Tavi, J. D. Bruton, A. Katz, and H. Westerblad Insulin and Inositol 1,4,5-Trisphosphate Trigger Abnormal Cytosolic Ca2+ Transients and Reveal Mitochondrial Ca2+ Handling Defects in Cardiomyocytes of ob/ob Mice Diabetes, August 1, 2005; 54(8): 2375 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Perez, J. A. Copello, Y. Li, K. L. Karko, L. Gomez, J. Ramos-Franco, M. Fill, A. L. Escobar, and R. Mejia-Alvarez Ryanodine receptor function in newborn rat heart Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2527 - H2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mery, F. Aimond, C. Menard, K. Mikoshiba, M. Michalak, and M. Puceat Initiation of Embryonic Cardiac Pacemaker Activity by Inositol 1,4,5-Trisphosphate-dependent Calcium Signaling Mol. Biol. Cell, May 1, 2005; 16(5): 2414 - 2423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Kirchhefer, H. A. Baba, G. Hanske, L. R. Jones, P. Kirchhof, W. Schmitz, and J. Neumann Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2216 - H2225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Zima and L. A. Blatter Inositol-1,4,5-trisphosphate-dependent Ca2+ signalling in cat atrial excitation-contraction coupling and arrhythmias J. Physiol., March 15, 2004; 555(3): 607 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ibarra, M. Estrada, L. Carrasco, M. Chiong, J. L. Liberona, C. Cardenas, G. Diaz-Araya, E. Jaimovich, and S. Lavandero Insulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes J. Biol. Chem., February 27, 2004; 279(9): 7554 - 7565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bouyer, Y. Zhou, and W. F. Boron An increase in intracellular calcium concentration that is induced by basolateral CO2 in rabbit renal proximal tubule Am J Physiol Renal Physiol, October 1, 2003; 285(4): F674 - F687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Papp, E. Dziak, M. Michalak, and M. Opas Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins J. Cell Biol., February 18, 2003; 160(4): 475 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, M. Puceat, C. Perez-Terzic, A. Mery, K. Nakamura, M. Michalak, K.-H. Krause, and M. E. Jaconi Calreticulin reveals a critical Ca2+ checkpoint in cardiac myofibrillogenesis J. Cell Biol., July 8, 2002; 158(1): 103 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. HOLMUHAMEDOV, L. LEWIS, M. BIENENGRAEBER, M. HOLMUHAMEDOVA, A. JAHANGIR, and A. TERZIC Suppression of human tumor cell proliferation through mitochondrial targeting FASEB J, July 1, 2002; 16(9): 1010 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. Dzeja, E. L. Holmuhamedov, C. Ozcan, D. Pucar, A. Jahangir, and A. Terzic Mitochondria: Gateway for Cytoprotection Circ. Res., October 26, 2001; 89(9): 744 - 746. [Full Text] [PDF]
|
|
|
|
|
|
H. Sauer, T. Theben, J. Hescheler, M. Lindner, M. C. Brandt, and M. Wartenberg Characteristics of calcium sparks in cardiomyocytes derived from embryonic stem cells Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H411 - H421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vassort Adenosine 5'-Triphosphate: a P2-Purinergic Agonist in the Myocardium Physiol Rev, April 1, 2001; 81(2): 767 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bony, S. Roche, U. Shuichi, T. Sasaki, M. A. Crackower, J. Penninger, H. Mano, and M. Puceat A Specific Role of Phosphatidylinositol 3-Kinase {gamma}: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells J. Cell Biol., February 20, 2001; 152(4): 717 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ralston, T. Ploug, J. Kalhovde, and T. Lomo Golgi Complex, Endoplasmic Reticulum Exit Sites, and Microtubules in Skeletal Muscle Fibers Are Organized by Patterned Activity J. Neurosci., February 1, 2001; 21(3): 875 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Perez-Terzic, A. M. Gacy, R. Bortolon, P. P. Dzeja, M. Puceat, M. Jaconi, F. G. Prendergast, and A. Terzic Directed Inhibition of Nuclear Import in Cellular Hypertrophy J. Biol. Chem., June 1, 2001; 276(23): 20566 - 20571. [Abstract] [Full Text] [PDF]
|
|
