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Vol. 11, Issue 9, 2845-2862, September 2000
Department of Biochemistry and Molecular Biology, The University of
Tokyo, Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan
In the fission yeast Schizosaccharomyces pombe, the
"start" of the cell cycle is controlled by the two functionally
redundant transcriptional regulator complexes, Res1p-Cdc10p and
Res2p-Cdc10p, that activate genes essential for the onset and
progression of S phase. The activity of the Res2p-Cdc10p complex is
regulated at least by the availability of the Rep2
trans-activator subunit in the mitotic cell cycle. We
have recently isolated the pas1+ gene as a
multicopy suppressor of the res1 null mutant. This gene
encodes a novel cyclin that shares homology with the Pho85 kinase-associated cyclins of the budding yeast Saccharomyces
cerevisiae. Genetic analysis reveals that Pas1 cyclin is
unrelated to phosphate metabolism and stimulates the G1-S
transition by specifically activating the Res2p-Cdc10p complex
independently of Rep2p. Pas1 cyclin also controls mating pheromone
signaling. Cells lacking pas1+ are highly
sensitive to mating pheromone, responding with facilitated G1 arrest and premature commitment to conjugation. Pas1
cyclin associates in vivo with both Cdc2 and Pef1 kinases, the latter of which is a fission yeast counterpart of the budding yeast Pho85 kinase, but genetic analysis indicates that the Pef1p-associated Pas1p
is responsible for the activation of Res2p-Cdc10p during the
G1-S transition.
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