Molecular Biology of the Cell track citations

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prokisch, H.
Right arrow Articles by Westermann, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prokisch, H.
Right arrow Articles by Westermann, B.

Vol. 11, Issue 9, 2961-2971, September 2000

Role of MMM1 in Maintaining Mitochondrial Morphology in Neurospora crassa

Holger Prokisch, Walter Neupert, and Benedikt Westermann*

Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 80336 München, Germany

Mmm1p is a protein required for maintenance of mitochondrial morphology in budding yeast. It was proposed that it is required to mediate the interaction of the mitochondrial outer membrane with the actin cytoskeleton. We report the cloning and characterization of MMM1 of the filamentous fungus Neurospora crassa, an organism that uses microtubules for mitochondrial transport. Mutation of the mmm-1 gene leads to a temperature-sensitive slow growth phenotype and female sterility. Mutant cells harbor abnormal giant mitochondria at all stages of the asexual life cycle, whereas actin filament-depolymerizing drugs have no effect on mitochondrial morphology. The MMM1 protein has a single transmembrane domain near the N terminus and exposes a large C-terminal domain to the cytosol. The protein can be imported into the outer membrane in a receptor-dependent manner. Our findings suggest that MMM1 is a factor of general importance for mitochondrial morphology independent of the cytoskeletal system used for mitochondrial transport.

* Corresponding author. E-mail address: benedikt.westermann{at}bio.med.uni-muenchen.de.

Molecular Biology of the Cell
Vol. 11, 2961-2971, September 2000
Copyright © 2000 by The American Society for Cell Biology


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
T. Becker, S. Pfannschmidt, B. Guiard, D. Stojanovski, D. Milenkovic, S. Kutik, N. Pfanner, C. Meisinger, and N. Wiedemann
Biogenesis of the Mitochondrial TOM Complex: Mim1 PROMOTES INSERTION AND ASSEMBLY OF SIGNAL-ANCHORED RECEPTORS
J. Biol. Chem., January 4, 2008; 283(1): 120 - 127.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
K. S. Dimmer, S. Jakobs, F. Vogel, K. Altmann, and B. Westermann
Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast
J. Cell Biol., January 3, 2005; 168(1): 103 - 115.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
F. Fuchs and B. Westermann
Role of Unc104/KIF1-related Motor Proteins in Mitochondrial Transport in Neurospora crassa
Mol. Biol. Cell, January 1, 2005; 16(1): 153 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Vasiljev, U. Ahting, F. E. Nargang, N. E. Go, S. J. Habib, C. Kozany, V. Panneels, I. Sinning, H. Prokisch, W. Neupert, et al.
Reconstituted TOM Core Complex and Tim9/Tim10 Complex of Mitochondria Are Sufficient for Translocation of the ADP/ATP Carrier across Membranes
Mol. Biol. Cell, March 1, 2004; 15(3): 1445 - 1458.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Kondo-Okamoto, J. M. Shaw, and K. Okamoto
Mmm1p Spans Both the Outer and Inner Mitochondrial Membranes and Contains Distinct Domains for Targeting and Foci Formation
J. Biol. Chem., December 5, 2003; 278(49): 48997 - 49005.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Herlan, F. Vogel, C. Bornhovd, W. Neupert, and A. S. Reichert
Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA
J. Biol. Chem., July 18, 2003; 278(30): 27781 - 27788.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. Hanekamp, M. K. Thorsness, I. Rebbapragada, E. M. Fisher, C. Seebart, M. R. Darland, J. A. Coxbill, D. L. Updike, and P. E. Thorsness
Maintenance of Mitochondrial Morphology Is Linked to Maintenance of the Mitochondrial Genome in Saccharomyces cerevisiae
Genetics, November 1, 2002; 162(3): 1147 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. S. Dimmer, S. Fritz, F. Fuchs, M. Messerschmitt, N. Weinbach, W. Neupert, and B. Westermann
Genetic Basis of Mitochondrial Function and Morphology in Saccharomyces cerevisiae
Mol. Biol. Cell, March 1, 2002; 13(3): 847 - 853.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F. Fuchs, H. Prokisch, W. Neupert, and B. Westermann
Interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa
J. Cell Sci., January 5, 2002; 115(9): 1931 - 1937.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. Klanner, H. Prokisch, and T. Langer
MAP-1 and IAP-1, Two Novel AAA Proteases with Catalytic Sites on Opposite Membrane Surfaces in Mitochondrial Inner Membrane of Neurospora crassa
Mol. Biol. Cell, September 1, 2001; 12(9): 2858 - 2869.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]