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Vol. 11, Issue 9, 2961-2971, September 2000

Role of MMM1 in Maintaining Mitochondrial Morphology in Neurospora crassa

Holger Prokisch, Walter Neupert, and Benedikt Westermann*

Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 80336 München, Germany

Mmm1p is a protein required for maintenance of mitochondrial morphology in budding yeast. It was proposed that it is required to mediate the interaction of the mitochondrial outer membrane with the actin cytoskeleton. We report the cloning and characterization of MMM1 of the filamentous fungus Neurospora crassa, an organism that uses microtubules for mitochondrial transport. Mutation of the mmm-1 gene leads to a temperature-sensitive slow growth phenotype and female sterility. Mutant cells harbor abnormal giant mitochondria at all stages of the asexual life cycle, whereas actin filament-depolymerizing drugs have no effect on mitochondrial morphology. The MMM1 protein has a single transmembrane domain near the N terminus and exposes a large C-terminal domain to the cytosol. The protein can be imported into the outer membrane in a receptor-dependent manner. Our findings suggest that MMM1 is a factor of general importance for mitochondrial morphology independent of the cytoskeletal system used for mitochondrial transport.

* Corresponding author. E-mail address: benedikt.westermann{at}bio.med.uni-muenchen.de.

Molecular Biology of the Cell
Vol. 11, 2961-2971, September 2000
Copyright © 2000 by The American Society for Cell Biology


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