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Vol. 12, Issue 10, 2907-2920, October 2001
Cell Biology and Metabolism Branch, National Institute of
Child Health and Human Development, National Institutes of Health,
Bethesda, Maryland, 20892
Adaptins are subunits of adaptor protein (AP) complexes
involved in the formation of intracellular transport vesicles and in
the selection of cargo for incorporation into the vesicles. In this
article, we report the results of a survey for adaptins from sequenced
genomes including those of man, mouse, the fruit fly Drosophila
melanogaster, the nematode Caenorhabditis
elegans, the plant Arabidopsis thaliana, and the
yeasts, Saccharomyces cerevisiae and
Schizosaccharomyces pombe. We find that humans, mice,
and Arabidopsis thaliana have four AP complexes (AP-1,
AP-2, AP-3, and AP-4), whereas D. melanogaster,
C. elegans, S. cerevisiae, and S.
pombe have only three (AP-1, AP-2, and AP-3). Additional diversification of AP complexes arises from the existence of adaptin isoforms encoded by distinct genes or resulting from alternative splicing of mRNAs. We complete the assignment of adaptins to AP complexes and provide information on the chromosomal localization, exon-intron structure, and pseudogenes for the different adaptins. In
addition, we discuss the structural and evolutionary relationships of
the adaptins and the genetic analyses of their function. Finally, we
extend our survey to adaptin-related proteins such as the GGAs and
stonins, which contain domains homologous to the adaptins.
Online version of this essay contains
supplemental tabular material. Online version is available at
www.molcellbiol.org.
*
Corresponding author: E-mail: juan{at}helix.nih.gov
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Y. Xu, J. C. Clark, B. J. Aronow, C. R. Dey, C. Liu, J. L. Wooldridge, and J. A. Whitsett Transcriptional Adaptation to Cystic Fibrosis Transmembrane Conductance Regulator Deficiency J. Biol. Chem., February 21, 2003; 278(9): 7674 - 7682. [Abstract] [Full Text] [PDF]
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T. L. Adair-Kirk, F. C. Dorsey, and J. V. Cox Multiple cytoplasmic signals direct the intracellular trafficking of chicken kidney AE1 anion exchangers in MDCK cells J. Cell Sci., February 15, 2003; 116(4): 655 - 663. [Abstract] [Full Text] [PDF]
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H. M. Ngo, M. Yang, K. Paprotka, M. Pypaert, H. Hoppe, and K. A. Joiner AP-1 in Toxoplasma gondii Mediates Biogenesis of the Rhoptry Secretory Organelle from a Post-Golgi Compartment J. Biol. Chem., February 7, 2003; 278(7): 5343 - 5352. [Abstract] [Full Text] [PDF]
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 J.-C. Lu, P. Scott, G. J. Strous, and L. A. Schuler Multiple Internalization Motifs Differentially Used by Prolactin Receptor Isoforms Mediate Similar Endocytic Pathways Mol. Endocrinol., November 1, 2002; 16(11): 2515 - 2527. [Abstract] [Full Text] [PDF]
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Y. Xu, S. Martin, D. E. James, and W. Hong GS15 Forms a SNARE Complex with Syntaxin 5, GS28, and Ykt6 and Is Implicated in Traffic in the Early Cisternae of the Golgi Apparatus Mol. Biol. Cell, October 1, 2002; 13(10): 3493 - 3507. [Abstract] [Full Text] [PDF]
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Z. Hua, P. Fatheddin, and T. R. Graham An Essential Subfamily of Drs2p-related P-Type ATPases Is Required for Protein Trafficking between Golgi Complex and Endosomal/Vacuolar System Mol. Biol. Cell, September 1, 2002; 13(9): 3162 - 3177. [Abstract] [Full Text] [PDF]
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M. Geyer, O. T. Fackler, and B. M. Peterlin Subunit H of the V-ATPase Involved in Endocytosis Shows Homology to beta -Adaptins Mol. Biol. Cell, June 1, 2002; 13(6): 2045 - 2056. [Abstract] [Full Text] [PDF]
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