![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 12, Issue 10, 2987-3003, October 2001
*Departments of Biochemistry and ¶Genetics, and
#Howard Hughes Medical Institute, Stanford University
School of Medicine, Stanford, California 94305; and
§Department of Biochemistry and ##Howard Hughes
Medical Institute, Baylor College of Medicine, Houston, Texas 77030
Eukaryotic cells respond to DNA damage by arresting the cell
cycle and modulating gene expression to ensure efficient DNA repair.
The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the
role of the Mec1 pathway in modulating the cellular response to DNA
damage, we used DNA microarrays to observe genomic expression in
Saccharomyces cerevisiae responding to two different
DNA-damaging agents. We compared the genome-wide expression patterns of
wild-type cells and mutants defective in Mec1 signaling, including
mec1, dun1, and crt1 mutants, under
normal growth conditions and in response to the methylating-agent
methylmethane sulfonate (MMS) and ionizing radiation. Here, we present
a comparative analysis of wild-type and mutant cells responding to
these DNA-damaging agents, and identify specific features of the gene
expression responses that are dependent on the Mec1 pathway. Among the
hundreds of genes whose expression was affected by Mec1p, one set of
genes appears to represent an MEC1-dependent expression signature of DNA damage. Other aspects of the genomic responses were independent of
Mec1p, and likely independent of DNA damage, suggesting the pleiotropic
effects of MMS and ionizing radiation. The complete data set as well as
supplemental materials is available at
http://www-genome.stanford.edu/mec1.
These authors contributed equally to this work.
Present addresses:
Lawrence Berkeley National Lab,
Berkeley, CA 94720;
Department of Biochemistry and
Molecular Genetics, University of Colorado Health Science Center,
Denver, CO 80262.
@
Corresponding author. E-mail address:
pbrown{at}cmgm.stanford.edu.
This article has been cited by other articles:
|
|
 |
|
  X. Wang, H. Xu, S.-W. Ha, D. Ju, and Y. Xie Proteasomal Degradation of Rpn4 in Saccharomyces cerevisiae Is Critical for Cell Viability Under Stressed Conditions Genetics, February 1, 2010; 184(2): 335 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Taschner, M. Harreman, Y. Teng, H. Gill, R. Anindya, S. L. Maslen, J. M. Skehel, R. Waters, and J. Q. Svejstrup A Role for Checkpoint Kinase-Dependent Rad26 Phosphorylation in Transcription-Coupled DNA Repair in Saccharomyces cerevisiae Mol. Cell. Biol., January 15, 2010; 30(2): 436 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. S. Swamy, C.-Y. Cho, S. Chiang, Z. T.-Y. Tsai, and H.-K. Tsai Impact of DNA-binding position variants on yeast gene expression Nucleic Acids Res., November 1, 2009; 37(21): 6991 - 7001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Roa, J. Lang, K. M. Culligan, M. Keller, S. Holec, V. Cognat, M.-H. Montane, G. Houlne, and M.-E. Chaboute Ribonucleotide Reductase Regulation in Response to Genotoxic Stress in Arabidopsis Plant Physiology, September 1, 2009; 151(1): 461 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yoshiyama, P. A. Conklin, N. D. Huefner, and A. B. Britt Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage PNAS, August 4, 2009; 106(31): 12843 - 12848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-s. C. Huang and E. Fraenkel Integrating Proteomic, Transcriptional, and Interactome Data Reveals Hidden Components of Signaling and Regulatory Networks Sci. Signal., July 28, 2009; 2(81): ra40 - ra40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, B. Kakaradov, S. R. Collins, L. Karotki, D. Fiedler, M. Shales, K. M. Shokat, T. C. Walther, N. J. Krogan, and D. Koller A Complex-based Reconstruction of the Saccharomyces cerevisiae Interactome Mol. Cell. Proteomics, June 1, 2009; 8(6): 1361 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ulitsky and R. Shamir Identifying functional modules using expression profiles and confidence-scored protein interactions Bioinformatics, May 1, 2009; 25(9): 1158 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Grossmann, J. Malinsky, W. Stahlschmidt, M. Loibl, I. Weig-Meckl, W. B. Frommer, M. Opekarova, and W. Tanner Plasma membrane microdomains regulate turnover of transport proteins in yeast J. Cell Biol., December 15, 2008; 183(6): 1075 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wu and M. Huang Dif1 Controls Subcellular Localization of Ribonucleotide Reductase by Mediating Nuclear Import of the R2 Subunit Mol. Cell. Biol., December 1, 2008; 28(23): 7156 - 7167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, H. Xu, D. Ju, and Y. Xie Disruption of Rpn4-Induced Proteasome Expression in Saccharomyces cerevisiae Reduces Cell Viability Under Stressed Conditions Genetics, December 1, 2008; 180(4): 1945 - 1953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rojas, C. W. Wright, B. Pina, and J. Portugal Genomewide Expression Profiling of Cryptolepine-Induced Toxicity in Saccharomyces cerevisiae Antimicrob. Agents Chemother., November 1, 2008; 52(11): 3844 - 3850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dutta, P. K. Patel, A. Rosebrock, A. Oliva, J. Leatherwood, and N. Rhind The DNA Replication Checkpoint Directly Regulates MBF-Dependent G1/S Transcription Mol. Cell. Biol., October 1, 2008; 28(19): 5977 - 5985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Celic, A. Verreault, and J. D. Boeke Histone H3 K56 Hyperacetylation Perturbs Replisomes and Causes DNA Damage Genetics, August 1, 2008; 179(4): 1769 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Bharucha, J. Ma, C. J. Dobry, S. K. Lawson, Z. Yang, and A. Kumar Analysis of the Yeast Kinome Reveals a Network of Regulated Protein Localization during Filamentous Growth Mol. Biol. Cell, July 1, 2008; 19(7): 2708 - 2717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tagkopoulos, Y.-C. Liu, and S. Tavazoie Predictive Behavior Within Microbial Genetic Networks Science, June 6, 2008; 320(5881): 1313 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vernon, K. Lobachev, and T. D. Petes High Rates of "Unselected" Aneuploidy and Chromosome Rearrangements in tel1 mec1 Haploid Yeast Strains Genetics, May 1, 2008; 179(1): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tan, H. Feizi, C. Luo, S. H. Fan, T. Ravasi, and T. G. Ideker A systems approach to delineate functions of paralogous transcription factors: Role of the Yap family in the DNA damage response PNAS, February 26, 2008; 105(8): 2934 - 2939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Pihur, S. Datta, and S. Datta Reconstruction of genetic association networks from microarray data: a partial least squares approach Bioinformatics, February 15, 2008; 24(4): 561 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Hershman, Q. Chen, J. Y. Lee, M. L. Kozak, P. Yue, L.-S. Wang, and F. B. Johnson Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae Nucleic Acids Res., January 17, 2008; 36(1): 144 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Brauer, C. Huttenhower, E. M. Airoldi, R. Rosenstein, J. C. Matese, D. Gresham, V. M. Boer, O. G. Troyanskaya, and D. Botstein Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast Mol. Biol. Cell, January 1, 2008; 19(1): 352 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Lehner, M. M. Stone, R. A. Farber, and T. D. Petes Ninety-Six Haploid Yeast Strains With Individual Disruptions of Open Reading Frames Between YOR097C and YOR192C, Constructed for the Saccharomyces Genome Deletion Project, Have an Additional Mutation in the Mismatch Repair Gene MSH3 Genetics, November 1, 2007; 177(3): 1951 - 1953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Buckley Comparative environmental genomics in non-model species: using heterologous hybridization to DNA-based microarrays J. Exp. Biol., May 1, 2007; 210(9): 1602 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Koren The role of the DNA damage checkpoint in regulation of translesion DNA synthesis Mutagenesis, May 1, 2007; 22(3): 155 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, K. Yang, C.-C. Chen, J. Feser, and M. Huang Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1 PNAS, February 13, 2007; 104(7): 2217 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Woolstencroft, T. H. Beilharz, M. A. Cook, T. Preiss, D. Durocher, and M. Tyers Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length J. Cell Sci., December 15, 2006; 119(24): 5178 - 5192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Brynildsen, L. M. Tran, and J. C. Liao A Gibbs sampler for the identification of gene expression and network connectivity consistency Bioinformatics, December 15, 2006; 22(24): 3040 - 3046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sokolov, I. G. Panyutin, and R. Neumann Genome-wide gene expression changes in normal human fibroblasts in response to low-LET gamma-radiation and high-LET-like 125IUdR exposures Radiat Prot Dosimetry, December 1, 2006; 122(1-4): 195 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Tringe, J. Willis, K. L. Liberatore, and S. W. Ruby The WTM Genes in Budding Yeast Amplify Expression of the Stress-Inducible Gene RNR3 Genetics, November 1, 2006; 174(3): 1215 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Belle, A. Tanay, L. Bitincka, R. Shamir, and E. K. O'Shea Quantification of protein half-lives in the budding yeast proteome PNAS, August 29, 2006; 103(35): 13004 - 13009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Seay, B. Hook, K. Evans, and M. Wickens A three-hybrid screen identifies mRNAs controlled by a regulatory protein RNA, August 1, 2006; 12(8): 1594 - 1600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Buckley, A. Y. Gracey, and G. N. Somero The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysis J. Exp. Biol., July 15, 2006; 209(14): 2660 - 2677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Workman, H. C. Mak, S. McCuine, J.-B. Tagne, M. Agarwal, O. Ozier, T. J. Begley, L. D. Samson, and T. Ideker A systems approach to mapping DNA damage response pathways. Science, May 19, 2006; 312(5776): 1054 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Neal, S. Karunanithi, A. Best, A. K.-C. So, R. M. Tanguay, H. L. Atwood, and J. T. Westwood Thermoprotection of synaptic transmission in a Drosophila heat shock factor mutant is accompanied by increased expression of Hsp83 and DnaJ-1 Physiol Genomics, May 16, 2006; 25(3): 493 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Barutcuoglu, R. E. Schapire, and O. G. Troyanskaya Hierarchical multi-label prediction of gene function Bioinformatics, April 1, 2006; 22(7): 830 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schmitt, P. Schwanewilm, J. Ludwig, and H. Lichtenberg-Frate Use of PMA1 as a Housekeeping Biomarker for Assessment of Toxicant-Induced Stress in Saccharomyces cerevisiae Appl. Envir. Microbiol., February 1, 2006; 72(2): 1515 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lubelsky, N. Reuven, and Y. Shaul Autorepression of Rfx1 Gene Expression: Functional Conservation from Yeast to Humans in Response to DNA Replication Arrest Mol. Cell. Biol., December 1, 2005; 25(23): 10665 - 10673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dolinski and D. Botstein Changing perspectives in yeast research nearly a decade after the genome sequence Genome Res., December 1, 2005; 15(12): 1611 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Scheel, M. Aldrin, I. K. Glad, R. Sorum, H. Lyng, and A. Frigessi The influence of missing value imputation on detection of differentially expressed genes from microarray data Bioinformatics, December 1, 2005; 21(23): 4272 - 4279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mercier, N. Berthault, N. Touleimat, F. Kepes, G. Fourel, E. Gilson, and M. Dutreix A haploid-specific transcriptional response to irradiation in Saccharomyces cerevisiae Nucleic Acids Res., November 30, 2005; 33(20): 6635 - 6643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wang and G. D. Stormo Identifying the conserved network of cis-regulatory sites of a eukaryotic genome PNAS, November 29, 2005; 102(48): 17400 - 17405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Xing and M. J. van der Laan A causal inference approach for constructing transcriptional regulatory networks Bioinformatics, November 1, 2005; 21(21): 4007 - 4013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sarver and J. DeRisi Fzf1p Regulates an Inducible Response to Nitrosative Stress in Saccharomyces cerevisiae Mol. Biol. Cell, October 1, 2005; 16(10): 4781 - 4791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-C. Lai, A. L. Kosorukoff, P. V. Burke, and K. E. Kwast Dynamical Remodeling of the Transcriptome during Short-Term Anaerobiosis in Saccharomyces cerevisiae: Differential Response and Role of Msn2 and/or Msn4 and Other Factors in Galactose and Glucose Media Mol. Cell. Biol., May 15, 2005; 25(10): 4075 - 4091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bilsland and J. A. Downs Tails of histones in DNA double-strand break repair Mutagenesis, May 1, 2005; 20(3): 153 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Mallory, G. Crudden, B. L. Johnson, C. Mo, C. A. Pierson, M. Bard, and R. J. Craven Dap1p, a Heme-Binding Protein That Regulates the Cytochrome P450 Protein Erg11p/Cyp51p in Saccharomyces cerevisiae Mol. Cell. Biol., March 1, 2005; 25(5): 1669 - 1679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kim, G. H. Golub, and H. Park Missing value estimation for DNA microarray gene expression data: local least squares imputation Bioinformatics, January 15, 2005; 21(2): 187 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zaim, E. Speina, and A. M. Kierzek Identification of New Genes Regulated by the Crt1 Transcription Factor, an Effector of the DNA Damage Checkpoint Pathway in Saccharomyces cerevisiae J. Biol. Chem., January 7, 2005; 280(1): 28 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Traven, A. Hammet, N. Tenis, C. L. Denis, and J. Heierhorst Ccr4-Not Complex mRNA Deadenylase Activity Contributes to DNA Damage Responses in Saccharomyces cerevisiae Genetics, January 1, 2005; 169(1): 65 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shapira, E. Segal, and D. Botstein Disruption of Yeast Forkhead-associated Cell Cycle Transcription by Oxidative Stress Mol. Biol. Cell, December 1, 2004; 15(12): 5659 - 5669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu and W. Xiao Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element Nucleic Acids Res., September 27, 2004; 32(17): 5066 - 5075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Rieger and G. Chu Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells Nucleic Acids Res., September 8, 2004; 32(16): 4786 - 4803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. U. Keller-Seitz, U. Certa, C. Sengstag, F. E. Wurgler, M. Sun, and M. Fasullo Transcriptional Response of Yeast to Aflatoxin B1: Recombinational Repair Involving RAD51 and RAD1 Mol. Biol. Cell, September 1, 2004; 15(9): 4321 - 4336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Smith, S. Nicholls, B. A. Morgan, A. J.P. Brown, and J. Quinn A Conserved Stress-activated Protein Kinase Regulates a Core Stress Response in the Human Pathogen Candida albicans Mol. Biol. Cell, September 1, 2004; 15(9): 4179 - 4190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Van Dyke, L. D. Nelson, R. G. Weilbaecher, and D. V. Mehta Stm1p, a G4 Quadruplex and Purine Motif Triplex Nucleic Acid-binding Protein, Interacts with Ribosomes and Subtelomeric Y' DNA in Saccharomyces cerevisiae J. Biol. Chem., June 4, 2004; 279(23): 24323 - 24333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dubacq, A. Chevalier, and C. Mann The Protein Kinase Snf1 Is Required for Tolerance to the Ribonucleotide Reductase Inhibitor Hydroxyurea Mol. Cell. Biol., March 15, 2004; 24(6): 2560 - 2572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.A. Cahill, A.W. Knight, N. Billinton, M.G. Barker, L. Walsh, P.O. Keenan, C.V. Williams, D.J. Tweats, and R.M. Walmsley The GreenScreen(R) genotoxicity assay: a screening validation programme Mutagenesis, March 1, 2004; 19(2): 105 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lesur and J. L. Campbell The Transcriptome of Prematurely Aging Yeast Cells Is Similar to That of Telomerase-deficient Cells Mol. Biol. Cell, March 1, 2004; 15(3): 1297 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lin and E. H. Blackburn Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA Genes & Dev., February 15, 2004; 18(4): 387 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Brodsky, B. T. Weinert, G. Tsang, Y. S. Rong, N. M. McGinnis, K. G. Golic, D. C. Rio, and G. M. Rubin Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage Mol. Cell. Biol., February 1, 2004; 24(3): 1219 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Gallo, D. L. Smith Jr., and J. S. Smith Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity Mol. Cell. Biol., February 1, 2004; 24(3): 1301 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watson, J. Mata, J. Bahler, A. Carr, and T. Humphrey Global Gene Expression Responses of Fission Yeast to Ionizing Radiation Mol. Biol. Cell, February 1, 2004; 15(2): 851 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Scholes, A. E. Kenny, E. R. Gamache, Z. Mou, and M. J. Curcio Activation of a LTR-retrotransposon by telomere erosion PNAS, December 23, 2003; 100(26): 15736 - 15741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Agarwal, P. D. Rogers, S. R. Baerson, M. R. Jacob, K. S. Barker, J. D. Cleary, L. A. Walker, D. G. Nagle, and A. M. Clark Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole, and Echinocandin Antifungal Agents in Saccharomyces cerevisiae J. Biol. Chem., September 12, 2003; 278(37): 34998 - 35015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lu, A. Nakorchevskiy, and E. M. Marcotte Expression deconvolution: A reinterpretation of DNA microarray data reveals dynamic changes in cell populations PNAS, September 2, 2003; 100(18): 10370 - 10375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Osborn and S. J. Elledge Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53 Genes & Dev., July 15, 2003; 17(14): 1755 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Cliften, P. Sudarsanam, A. Desikan, L. Fulton, B. Fulton, J. Majors, R. Waterston, B. A. Cohen, and M. Johnston Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting Science, July 4, 2003; 301(5629): 71 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yao, Z. Zhang, X. An, B. Bucci, D. L. Perlstein, J. Stubbe, and M. Huang Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways PNAS, May 27, 2003; 100(11): 6628 - 6633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Ostapenko and M. J. Solomon Budding Yeast CTDK-I Is Required for DNA Damage-Induced Transcription Eukaryot. Cell, April 1, 2003; 2(2): 274 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Hand, N. Jia, M. Bard, and R. J. Craven Saccharomyces cerevisiae Dap1p, a Novel DNA Damage Response Protein Related to the Mammalian Membrane-Associated Progesterone Receptor Eukaryot. Cell, April 1, 2003; 2(2): 306 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Conlon, X. S. Liu, J. D. Lieb, and J. S. Liu Integrating regulatory motif discovery and genome-wide expression analysis PNAS, March 18, 2003; 100(6): 3339 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. BOTSTEIN Genomic Perspective and Cancer Cold Spring Harb Symp Quant Biol, January 1, 2003; 68(0): 417 - 424. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Garcia, H. Bruchet, D. Camescasse, F. Granier, D. Bouchez, and A. Tissier AtATM Is Essential for Meiosis and the Somatic Response to DNA Damage in Plants PLANT CELL, January 1, 2003; 15(1): 119 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chen, W. M. Toone, J. Mata, R. Lyne, G. Burns, K. Kivinen, A. Brazma, N. Jones, and J. Bahler Global Transcriptional Responses of Fission Yeast to Environmental Stress Mol. Biol. Cell, January 1, 2003; 14(1): 214 - 229. [Abstract] [Full Text]
|
|
|
|
|
|
M. Chang, M. Bellaoui, C. Boone, and G. W. Brown A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage PNAS, December 24, 2002; 99(26): 16934 - 16939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kiechle, P. Manivasakam, F. Eckardt-Schupp, R. H. Schiestl, and A. A. Friedl Promoter-trapping in Saccharomyces cerevisiae by radiation-assisted fragment insertion Nucleic Acids Res., December 15, 2002; 30(24): e136 - e136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Crespo and M. N. Hall Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae Microbiol. Mol. Biol. Rev., December 1, 2002; 66(4): 579 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Begley, A. S. Rosenbach, T. Ideker, and L. D. Samson Damage Recovery Pathways in Saccharomyces cerevisiae Revealed by Genomic Phenotyping and Interactome Mapping Mol. Cancer Res., December 1, 2002; 1(2): 103 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Horak, N. M. Luscombe, J. Qian, P. Bertone, S. Piccirrillo, M. Gerstein, and M. Snyder Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae Genes & Dev., December 1, 2002; 16(23): 3017 - 3033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nautiyal, J. L. DeRisi, and E. H. Blackburn The genome-wide expression response to telomerase deletion in Saccharomycescerevisiae PNAS, July 9, 2002; 99(14): 9316 - 9321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Birrell, J. A. Brown, H. I. Wu, G. Giaever, A. M. Chu, R. W. Davis, and J. M. Brown Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents PNAS, June 25, 2002; 99(13): 8778 - 8783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, C. L. Liu, J. D. Storey, R. J. Tibshirani, D. Herschlag, and P. O. Brown Precision and functional specificity in mRNA decay PNAS, April 30, 2002; 99(9): 5860 - 5865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Kryukov, R. A. Kumar, A. Koc, Z. Sun, and V. N. Gladyshev Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase PNAS, April 2, 2002; 99(7): 4245 - 4250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, C. L. Liu, J. D. Storey, R. J. Tibshirani, D. Herschlag, and P. O. Brown Precision and functional specificity in mRNA decay PNAS, April 30, 2002; 99(9): 5860 - 5865. [Abstract] [Full Text] [PDF]
|
|
