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Vol. 12, Issue 2, 449-462, February 2001
*Molecular and Structural Neurobiology and Gene Therapy Program,
State University of New York, Buffalo, New York 14214; Arizona State
University, Tempe, Arizona 85287; In bovine adrenal medullary cells synergistically acting
type 1 and type 2 angiotensin II (AII) receptors activate the
fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive
promoter element. Both the type 1 and type 2 AII receptors and
the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase
C-dependent signaling pathways activate the FGF-2 promoter through a
novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of
the AII-responsive element in the FGF-2 promoter.
The Scripps Research
Institute, La Jolla, California 92037; and §University of
Pennsylvania, Schools of Medicine and Veterinary Medicine,
Philadelphia, Pennsylvania 19104
These authors contributed equally to this work.
Present address: Biosignaling Department, National
Institute of Bioscience and Human Technology, Higashi 1-1, Tsukuba,
Ibaraki 305-8566, Japan.
¶
Corresponding author. E-mail address:
mks4{at}Buffalo.edu.
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