![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 12, Issue 3, 685-698, March 2001
Sidney Kimmel Cancer Center, San Diego, CA 92121
Select lipid-anchored proteins such as
glycosylphosphatidylinositol (GPI)-anchored proteins and
nonreceptor tyrosine kinases may preferentially partition into
sphingomyelin-rich and cholesterol-rich plasmalemmal microdomains,
thereby acquiring resistance to detergent extraction. Two such domains,
caveolae and lipid rafts, are morphologically and biochemically
distinct, contain many signaling molecules, and may function in
compartmentalizing cell surface signaling. Subfractionation and
confocal immunofluorescence microscopy reveal that, in lung tissue and
in cultured endothelial and epithelial cells, heterotrimeric G proteins
(Gi, Gq, Gs, and
G
) target discrete cell surface
microdomains. Gq specifically concentrates in caveolae,
whereas Gi and Gs concentrate much more in
lipid rafts marked by GPI-anchored proteins (5' nucleotidase and folate receptor). Gq, apparently without
G subunits, stably associates with
plasmalemmal and cytosolic caveolin. Gi and Gs
interact with G subunits but not
caveolin. Gi and Gs, unlike Gq,
readily move out of caveolae. Thus, caveolin may function as a scaffold
to trap, concentrate, and stabilize Gq preferentially
within caveolae over lipid rafts. In N2a cells lacking caveolae and
caveolin, Gq, Gi, and Gs all concentrate in lipid rafts as a complex with
G. Without effective physiological
interaction with caveolin, G proteins tend by default to segregate in
lipid rafts. The ramifications of the segregated microdomain
distribution and the Gq-caveolin complex without
G for trafficking, signaling, and
mechanotransduction are discussed.
This article has been cited by other articles:
|
|
 |
|
  Y. Li, J. Yu, Y. Wang, N. M. Griffin, F. Long, S. Shore, P. Oh, and J. E. Schnitzer Enhancing Identifications of Lipid-embedded Proteins by Mass Spectrometry for Improved Mapping of Endothelial Plasma Membranes in Vivo Mol. Cell. Proteomics, June 1, 2009; 8(6): 1219 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Heakal and M. Kester Nanoliposomal Short-Chain Ceramide Inhibits Agonist-Dependent Translocation of Neurotensin Receptor 1 to Structured Membrane Microdomains in Breast Cancer Cells Mol. Cancer Res., May 1, 2009; 7(5): 724 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Norambuena, M. I. Poblete, M. V. Donoso, C. S. Espinoza, A. Gonzalez, and J. P. Huidobro-Toro P2Y1 Receptor Activation Elicits Its Partition out of Membrane Rafts and Its Rapid Internalization from Human Blood Vessels: Implications for Receptor Signaling Mol. Pharmacol., December 1, 2008; 74(6): 1666 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Pontier, Y. Percherancier, S. Galandrin, A. Breit, C. Gales, and M. Bouvier Cholesterol-dependent Separation of the {beta}2-Adrenergic Receptor from Its Partners Determines Signaling Efficacy: INSIGHT INTO NANOSCALE ORGANIZATION OF SIGNAL TRANSDUCTION J. Biol. Chem., September 5, 2008; 283(36): 24659 - 24672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. O. Rybin, J. Guo, Z. Gertsberg, S. J. Feinmark, and S. F. Steinberg Phorbol 12-Myristate 13-Acetate-dependent Protein Kinase C{delta}-Tyr311 Phosphorylation in Cardiomyocyte Caveolae J. Biol. Chem., June 27, 2008; 283(26): 17777 - 17788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sengupta, F. Philip, and S. Scarlata Caveolin-1 alters Ca2+ signal duration through specific interaction with the G{alpha}q family of G proteins J. Cell Sci., May 1, 2008; 121(9): 1363 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Linden, V. R. Martins, M. A. M. Prado, M. Cammarota, I. Izquierdo, and R. R. Brentani Physiology of the Prion Protein Physiol Rev, April 1, 2008; 88(2): 673 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Palygin, J. M. Pettus, and E. F. Shibata Regulation of caveolar cardiac sodium current by a single Gs{alpha} histidine residue Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1693 - H1699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, F. Tan, Y. Zhang, and R. A. Skidgel Carboxypeptidase M and Kinin B1 Receptors Interact to Facilitate Efficient B1 Signaling from B2 Agonists J. Biol. Chem., March 21, 2008; 283(12): 7994 - 8004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Donati, Y. Dwivedi, R. C. Roberts, R. R. Conley, G. N. Pandey, and M. M. Rasenick Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gs{alpha} Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase J. Neurosci., March 19, 2008; 28(12): 3042 - 3050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Morris, B. Lei, Y.-X. Wu, G. A. Michelotti, and D. A. Schwinn The {alpha}1a-Adrenergic Receptor Occupies Membrane Rafts with Its G Protein Effectors but Internalizes via Clathrin-coated Pits J. Biol. Chem., February 1, 2008; 283(5): 2973 - 2985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Peres, D. M. Aronoff, C. H. Serezani, N. Flamand, L. H. Faccioli, and M. Peters-Golden Specific Leukotriene Receptors Couple to Distinct G Proteins to Effect Stimulation of Alveolar Macrophage Host Defense Functions J. Immunol., October 15, 2007; 179(8): 5454 - 5461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Renner, K. Glebov, T. Lang, E. Papusheva, S. Balakrishnan, B. Keller, D. W. Richter, R. Jahn, and E. Ponimaskin Localization of the Mouse 5-Hydroxytryptamine1A Receptor in Lipid Microdomains Depends on Its Palmitoylation and Is Involved in Receptor-Mediated Signaling Mol. Pharmacol., September 1, 2007; 72(3): 502 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Abankwa and H. Vogel A FRET map of membrane anchors suggests distinct microdomains of heterotrimeric G proteins J. Cell Sci., August 15, 2007; 120(16): 2953 - 2962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carlile-Klusacek and V. Rizzo Endothelial cytoskeletal reorganization in response to PAR1 stimulation is mediated by membrane rafts but not caveolae Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H366 - H375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Awasthi, S. K. Mandal, V. Papanna, L. V. M. Rao, and U. R. Pendurthi Modulation of Tissue Factor-Factor VIIa Signaling by Lipid Rafts and Caveolae Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1447 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Fowler, P. Aryal, K. F. Suen, and P. A. Slesinger Evidence for association of GABAB receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins J. Physiol., April 1, 2007; 580(1): 51 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Perona, O. Vogler, J. M. Sanchez-Dominguez, E. Montero, P. V. Escriba, and V. Ruiz-Gutierrez Consumption of Virgin Olive Oil Influences Membrane Lipid Composition and Regulates Intracellular Signaling in Elderly Adults With Type 2 Diabetes Mellitus J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2007; 62(3): 256 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Kwiatek, R. D. Minshall, D. R. Cool, R. A. Skidgel, A. B. Malik, and C. Tiruppathi Caveolin-1 Regulates Store-Operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells Mol. Pharmacol., October 1, 2006; 70(4): 1174 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Linder, R. Leite, K. Lauria, T. M. Mills, and R. C. Webb Penile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1302 - R1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. L. Smith, Y. Lei, J. Liu, M. E. Cahill, G. M. Hagen, B. G. Barisas, and D. A. Roess Luteinizing Hormone Receptors Translocate to Plasma Membrane Microdomains after Binding of Human Chorionic Gonadotropin Endocrinology, April 1, 2006; 147(4): 1789 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Fitzsimons, U. A. Gompels, D. Verzijl, H. F. Vischer, C. Mattick, R. Leurs, and M. J. Smit Chemokine-Directed Trafficking of Receptor Stimulus to Different G Proteins: Selective Inducible and Constitutive Signaling by Human Herpesvirus 6-Encoded Chemokine Receptor U51 Mol. Pharmacol., March 1, 2006; 69(3): 888 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Urs, K. T. Jones, P. D. Salo, J. E. Severin, J. Trejo, and H. Radhakrishna A requirement for membrane cholesterol in the {beta}-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors J. Cell Sci., November 15, 2005; 118(22): 5291 - 5304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sugama, S. Ohkubo, M. Atsumi, and N. Nakahata Mastoparan Changes the Cellular Localization of G{alpha}q/11 and G{beta} through Its Binding to Ganglioside in Lipid Rafts Mol. Pharmacol., November 1, 2005; 68(5): 1466 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Head, H. H. Patel, D. M. Roth, N. C. Lai, I. R. Niesman, M. G. Farquhar, and P. A. Insel G-protein-coupled Receptor Signaling Components Localize in Both Sarcolemmal and Intracellular Caveolin-3-associated Microdomains in Adult Cardiac Myocytes J. Biol. Chem., September 2, 2005; 280(35): 31036 - 31044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rudajev, J. Novotny, L. Hejnova, G. Milligan, and P. Svoboda Dominant Portion of Thyrotropin-Releasing Hormone Receptor Is Excluded from Lipid Domains. Detergent-Resistant and Detergent-Sensitive Pools of TRH Receptor and Gq{alpha}/G11{alpha} Protein J. Biochem., August 1, 2005; 138(2): 111 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Linder, L. P. McCluskey, K. R. Cole III, K. M. Lanning, and R. C. Webb Dynamic Association of Nitric Oxide Downstream Signaling Molecules with Endothelial Caveolin-1 in Rat Aorta J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 9 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Hill, E. Almasri, W. G. Ruiz, G. Apodaca, and M. L. Zeidel Water and solute permeability of rat lung caveolae: high permeabilities explained by acyl chain unsaturation Am J Physiol Cell Physiol, July 1, 2005; 289(1): C33 - C41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Allen, J. Z. Yu, R. J. Donati, and M. M. Rasenick {beta}-Adrenergic Receptor Stimulation Promotes G{alpha}s Internalization through Lipid Rafts: A Study in Living Cells Mol. Pharmacol., May 1, 2005; 67(5): 1493 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Monastyrskaya, A. Hostettler, S. Buergi, and A. Draeger The NK1 Receptor Localizes to the Plasma Membrane Microdomains, and Its Activation Is Dependent on Lipid Raft Integrity J. Biol. Chem., February 25, 2005; 280(8): 7135 - 7146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inoue, M. A. Digman, M. Cheng, S. Y. Breusegem, N. Halaihel, V. Sorribas, W. W. Mantulin, E. Gratton, N. P. Barry, and M. Levi Partitioning of NaPi Cotransporter in Cholesterol-, Sphingomyelin-, and Glycosphingolipid-enriched Membrane Domains Modulates NaPi Protein Diffusion, Clustering, and Activity J. Biol. Chem., November 19, 2004; 279(47): 49160 - 49171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Shajahan, C. Tiruppathi, A. V. Smrcka, A. B. Malik, and R. D. Minshall G{beta}{gamma} Activation of Src Induces Caveolae-mediated Endocytosis in Endothelial Cells J. Biol. Chem., November 12, 2004; 279(46): 48055 - 48062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Abrahamsen, G. Baillie, J. Ngai, T. Vang, K. Nika, A. Ruppelt, T. Mustelin, M. Zaccolo, M. Houslay, and K. Tasken TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling J. Immunol., October 15, 2004; 173(8): 4847 - 4858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gonzalez, A. Nagiel, A. J. Lin, D. E. Golan, and T. Michel Small Interfering RNA-mediated Down-regulation of Caveolin-1 Differentially Modulates Signaling Pathways in Endothelial Cells J. Biol. Chem., September 24, 2004; 279(39): 40659 - 40669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Czarny and J. E. Schnitzer Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1344 - H1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Vogler, J. Casas, D. Capo, T. Nagy, G. Borchert, G. Martorell, and P. V. Escriba The G{beta}{gamma} Dimer Drives the Interaction of Heterotrimeric Gi Proteins with Nonlamellar Membrane Structures J. Biol. Chem., August 27, 2004; 279(35): 36540 - 36545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Azpiazu and N. Gautam A Fluorescence Resonance Energy Transfer-based Sensor Indicates that Receptor Access to a G Protein Is Unrestricted in a Living Mammalian Cell J. Biol. Chem., June 25, 2004; 279(26): 27709 - 27718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Gratton, P. Bernatchez, and W. C. Sessa Caveolae and Caveolins in the Cardiovascular System Circ. Res., June 11, 2004; 94(11): 1408 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wadehra, L. Goodglick, and J. Braun The Tetraspan Protein EMP2 Modulates the Surface Expression of Caveolins and Glycosylphosphatidyl Inositol-linked Proteins Mol. Biol. Cell, May 1, 2004; 15(5): 2073 - 2083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Costa, Y. Song, P. Macours, C. Massart, M. C. Many, S. Costagliola, J. E. Dumont, J. Van Sande, and V. Vanvooren Sphingolipid-Cholesterol Domains (Lipid Rafts) in Normal Human and Dog Thyroid Follicular Cells Are Not Involved in Thyrotropin Receptor Signaling Endocrinology, March 1, 2004; 145(3): 1464 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vallejo and C. D. Hardin Metabolic organization in vascular smooth muscle: distribution and localization of caveolin-1 and phosphofructokinase Am J Physiol Cell Physiol, January 1, 2004; 286(1): C43 - C54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mukherjee, L. Arnaud, and J. A. Cooper Lipid-dependent Recruitment of Neuronal Src to Lipid Rafts in the Brain J. Biol. Chem., October 17, 2003; 278(42): 40806 - 40814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Rizzo, C. Morton, N. DePaola, J. E. Schnitzer, and P. F. Davies Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1720 - H1729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Igarashi, P. A. Erwin, A. P. V. Dantas, H. Chen, and T. Michel VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors PNAS, September 16, 2003; 100(19): 10664 - 10669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Peters, A. Mironov Jr., D. Peretz, E. van Donselaar, E. Leclerc, S. Erpel, S. J. DeArmond, D. R. Burton, R. A. Williamson, M. Vey, et al. Trafficking of prion proteins through a caveolae-mediated endosomal pathway J. Cell Biol., August 18, 2003; 162(4): 703 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. GRATZINGER, S. CANOSA, B. ENGELHARDT, and J. A. MADRI Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho FASEB J, August 1, 2003; 17(11): 1458 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Frank, S. E. Woodman, D. S. Park, and M. P. Lisanti Caveolin, Caveolae, and Endothelial Cell Function Arterioscler. Thromb. Vasc. Biol., July 1, 2003; 23(7): 1161 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hessel, M. Heck, P. Muller, A. Herrmann, and K. P. Hofmann Signal Transduction in the Visual Cascade Involves Specific Lipid-Protein Interactions J. Biol. Chem., June 13, 2003; 278(25): 22853 - 22860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. O. Rybin, E. Pak, S. Alcott, and S. F. Steinberg Developmental Changes in {beta}2-Adrenergic Receptor Signaling in Ventricular Myocytes: the Role of Gi proteins and Caveolae Microdomains Mol. Pharmacol., June 1, 2003; 63(6): 1338 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. R. Nabi and P. U. Le Caveolae/raft-dependent endocytosis J. Cell Biol., May 26, 2003; 161(4): 673 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ledoux, I. Runembert, K. Koumanov, J.B. Michel, G. Trugnan, and G. Friedlander Hypoxia Enhances Ecto-5'-Nucleotidase Activity and Cell Surface Expression in Endothelial Cells: Role of Membrane Lipids Circ. Res., May 2, 2003; 92(8): 848 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Roessler and M. Muenke How a Hedgehog might see holoprosencephaly Hum. Mol. Genet., April 2, 2003; 12(90001): R15 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Pike Lipid rafts: bringing order to chaos J. Lipid Res., April 1, 2003; 44(4): 655 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fourgeaud, A.-S. Bessis, F. Rossignol, J.-P. Pin, J.-C. Olivo-Marin, and A. Hemar The Metabotropic Glutamate Receptor mGluR5 Is Endocytosed by a Clathrin-independent Pathway J. Biol. Chem., March 28, 2003; 278(14): 12222 - 12230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Czarny, J. Liu, P. Oh, and J. E. Schnitzer Transient Mechanoactivation of Neutral Sphingomyelinase in Caveolae to Generate Ceramide J. Biol. Chem., February 7, 2003; 278(7): 4424 - 4430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nanjundan and F. Possmayer Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L1 - L23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Labrecque, I. Royal, D. S. Surprenant, C. Patterson, D. Gingras, and R. Beliveau Regulation of Vascular Endothelial Growth Factor Receptor-2 Activity by Caveolin-1 and Plasma Membrane Cholesterol Mol. Biol. Cell, January 1, 2003; 14(1): 334 - 347. [Abstract] [Full Text]
|
|
|
|
|
|
R. S. Ostrom, X. Liu, B. P. Head, C. Gregorian, T. M. Seasholtz, and P. A. Insel Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Noncaveolin Domains Mol. Pharmacol., November 1, 2002; 62(5): 983 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nebl, K. N. Pestonjamasp, J. D. Leszyk, J. L. Crowley, S. W. Oh, and E. J. Luna Proteomic Analysis of a Detergent-resistant Membrane Skeleton from Neutrophil Plasma Membranes J. Biol. Chem., November 1, 2002; 277(45): 43399 - 43409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Razani, S. E. Woodman, and M. P. Lisanti Caveolae: From Cell Biology to Animal Physiology Pharmacol. Rev., September 1, 2002; 54(3): 431 - 467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kimura, S. Mora, S. Shigematsu, J. E. Pessin, and A. R. Saltiel The Insulin Receptor Catalyzes the Tyrosine Phosphorylation of Caveolin-1 J. Biol. Chem., August 9, 2002; 277(33): 30153 - 30158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. BABIYCHUK, K. MONASTYRSKAYA, F. C. BURKHARD, S. WRAY, and A. DRAEGER Modulating signaling events in smooth muscle: cleavage of annexin 2 abolishes its binding to lipid rafts FASEB J, August 1, 2002; 16(10): 1177 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hekman, H. Hamm, A. V. Villar, B. Bader, J. Kuhlmann, J. Nickel, and U. R. Rapp Associations of B- and C-Raf with Cholesterol, Phosphatidylserine, and Lipid Second Messengers. PREFERENTIAL BINDING OF Raf TO ARTIFICIAL LIPID RAFTS J. Biol. Chem., June 28, 2002; 277(27): 24090 - 24102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Berlot A Highly Effective Dominant Negative alpha s Construct Containing Mutations That Affect Distinct Functions Inhibits Multiple Gs-coupled Receptor Signaling Pathways J. Biol. Chem., May 31, 2002; 277(23): 21080 - 21085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Assmann Heterotrimeric and Unconventional GTP Binding Proteins in Plant Cell Signaling PLANT CELL, May 1, 2002; 14(90001): S355 - 373. [Full Text] [PDF]
|
|
|
|
|
|
D. H. Nguyen and D. Taub CXCR4 Function Requires Membrane Cholesterol: Implications for HIV Infection J. Immunol., April 15, 2002; 168(8): 4121 - 4126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S Ostrom New Determinants of Receptor-Effector Coupling: Trafficking and Compartmentation in Membrane Microdomains Mol. Pharmacol., March 1, 2002; 61(3): 473 - 476. [Full Text] [PDF]
|
|
|
|
|
|
T. Sabourin, L. Bastien, D. R. Bachvarov, and F. Marceau Agonist-Induced Translocation of the Kinin B1 Receptor to Caveolae-Related Rafts Mol. Pharmacol., March 1, 2002; 61(3): 546 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Alenghat and D. E. Ingber Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins Sci. Signal., February 12, 2002; 2002(119): pe6 - pe6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Z. Yu and M. M. Rasenick Real-Time Visualization of a Fluorescent Galpha s: Dissociation of the Activated G Protein from Plasma Membrane Mol. Pharmacol., February 1, 2002; 61(2): 352 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Isshiki, J. Ando, K. Yamamoto, T. Fujita, Y. Ying, and R. G. W. Anderson Sites of Ca2+ wave initiation move with caveolae to the trailing edge of migrating cells J. Cell Sci., January 2, 2002; 115(3): 475 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Dunphy, W. K. Greentree, and M. E. Linder Enrichment of G-protein Palmitoyltransferase Activity in Low Density Membranes. IN VITRO RECONSTITUTION OF Galpha i TO THESE DOMAINS REQUIRES PALMITOYLTRANSFERASE ACTIVITY J. Biol. Chem., November 9, 2001; 276(46): 43300 - 43304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ostrom, C. Gregorian, R. M. Drenan, Y. Xiang, J. W. Regan, and P. A. Insel Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase J. Biol. Chem., November 2, 2001; 276(45): 42063 - 42069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Farazi, G. Waksman, and J. I. Gordon The Biology and Enzymology of Protein N-Myristoylation J. Biol. Chem., October 19, 2001; 276(43): 39501 - 39504. [Full Text] [PDF]
|
|
|
|
|
|
C. A.O. Stuermer, D. M. Lang, F. Kirsch, M. Wiechers, S.-O. Deininger, and H. Plattner Glycosylphosphatidyl Inositol-anchored Proteins and fyn Kinase Assemble in Noncaveolar Plasma Membrane Microdomains Defined by Reggie-1 and -2 Mol. Biol. Cell, October 1, 2001; 12(10): 3031 - 3045. [Abstract] [Full Text] [PDF]
|
|
