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Vol. 12, Issue 5, 1409-1419, May 2001

Dribble, the Drosophila KRR1p Homologue, Is Involved in rRNA Processing

H.Y. Edwin Chan,^* Saverio Brogna, and Cahir J. O'Kane

Department of Genetics, University of Cambridge, Cambridge CB2 3EH, England, United Kingdom

The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe⁺ is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected.

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Present addresses: ^* Howard Hughes Medical Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018; Howard Hughes Medical Institute, Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454.

Corresponding author. E-mail address: c.okane{at}gen.cam.ac.uk

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Molecular Biology of the Cell
Vol. 12, 1409-1419, May 2001
Copyright © 2001 by The American Society for Cell Biology

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