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Vol. 12, Issue 7, 2087-2098, July 2001
and
*Centro de Biologia Molecular, Consejo Superior de Investigaciones
Cientificas, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain; and Cultured neurons obtained from a hypomorphous MAP1B mutant mouse
line display a selective and significant inhibition of axon formation
that reflects a delay in axon outgrowth and a reduced rate of
elongation. This phenomenon is paralleled by decreased microtubule
formation and dynamics, which is dramatic at the distal axonal segment,
as well as in growth cones, where the more recently assembled
microtubule polymer normally predominates. These neurons also have
aberrant growth cone formation and increased actin-based protrusive
activity. Taken together, this study provides direct evidence showing
that by promoting microtubule dynamics and regulating cytoskeletal
organization MAP1B has a crucial role in axon formation.
Instituto Investigación
Médica Mercedes y Martín Ferreyra, (INIMEC-Consejo
Nacional de Investigaciones Cientificas y Técnicas de Argentina),
Córdoba, Argentina
Corresponding author. E-mail
address: acaceres{at}immf.uncor.edu or javila{at}cbm.uam.es.
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