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Vol. 12, Issue 9, 2835-2845, September 2001

Calreticulin, a Calcium-binding Molecular Chaperone, Is Required for Stress Response and Fertility in Caenorhabditis elegans

Byung-Jae Park,*dagger Duk-Gyu Lee,*dagger Dagger Jae-Ran Yu,§ Sun-ki Jung,*Dagger Kyuyeong Choi,* Jungsoo Lee,* Jiyeon Lee,* Yun Sik Kim,* Jin Il Lee,* Jae Young Kwon, Junho Lee, Andrew Singson,# Woo Keun Song,* Soo Hyun Eom,* Chul-Seung Park,* Do Han Kim,* Jaya Bandyopadhyay,* and Joohong Ahnn*@

 *Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, 500-712, Korea;  §Department of Parasitology, College of Medicine, Kon-kuk University, Chungju 380-710, Korea;  Department of Biology, Yonsei University, Seoul 120-749, Korea; and  #Waksman Institute, Rutgers University, Piscataway, New Jersey 08854

Calreticulin (CRT), a Ca2+-binding protein known to have many cellular functions, including regulation of Ca2+ homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice. Here, we report the functional characterization of Caenorhabditis elegans calreticulin (crt-1). A crt-1 null mutant does not result in embryonic lethality but shows temperature-dependent reproduction defects. In C. elegans CRT-1 is expressed in the intestine, pharynx, body-wall muscles, head neurons, coelomocytes, and in sperm. crt-1 males exhibit reduced mating efficiency and defects late in sperm development in addition to defects in oocyte development and/or somatic gonad function in hermaphrodites. Furthermore, crt-1 and itr-1 (inositol triphosphate receptor) together are required for normal behavioral rhythms. crt-1 transcript level is elevated under stress conditions, suggesting that CRT-1 may be important for stress-induced chaperoning function in C. elegans.

dagger These authors contributed equally to this work.

Dagger Current Address: Hanwha Chemical, Research and Development Center, Taejeon 305-345, Korea.

@ Corresponding author. E-mail address: joohong{at}kjist.ac.kr.

Molecular Biology of the Cell
Vol. 12, 2835-2845, September 2001
Copyright © 2001 by The American Society for Cell Biology


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