![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vol. 13, Issue 10, 3452-3465, October 2002
§§
*Biotechnology Research Institute, National Research Council of
Canada, Montreal, Quebec, Canada H4P 2R2; and The ability of the pathogenic fungus Candida
albicans to switch from a yeast to a hyphal morphology in
response to external signals is implicated in its pathogenicity. We
used glass DNA microarrays to investigate the transcription profiles of
6333 predicted ORFs in cells undergoing this transition and their
responses to changes in temperature and culture medium. We have
identified several genes whose transcriptional profiles are similar to
those of known virulence factors that are modulated by the switch to hyphal growth caused by addition of serum and a 37°C growth
temperature. Time course analysis of this transition identified
transcripts that are induced before germ tube initiation and shut off
later in the developmental process. A strain deleted for the Efg1p and Cph1p transcription factors is defective in hyphae formation, and its
response to serum and increased temperature is almost identical to the
response of a wild-type strain grown at 37°C in the absence of serum.
Thus Efg1p and Cph1p are needed for the activation of the
transcriptional program that is induced by the presence of serum.
Institute
for Marine Bioscience, National Research Council of Canada, Halifax,
Nova Scotia, Canada B3H 3Z1
Corresponding author. E-mail address:
andre.nantel{at}bri.nrc.ca.
Present addresses:
§Department of Biochemistry and
Molecular Biology, University of Calgary, Calgary, AB Canada T2N 4N1;
¶Department of Biochemistry, McGill University,
Montreal, PQ Canada H3G 1Y6.
Online version of this article contains supplemental
data. Online version is available at www.molbiolcell.org.
This article has been cited by other articles:
|
|
 |
|
  S. Goyard, P. Knechtle, M. Chauvel, A. Mallet, M.-C. Prevost, C. Proux, J.-Y. Coppee, P. Schwartz, F. Dromer, H. Park, et al. The Yak1 Kinase Is Involved in the Initiation and Maintenance of Hyphal Growth in Candida albicans Mol. Biol. Cell, May 1, 2008; 19(5): 2251 - 2266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Bahn, M. Molenda, J. F. Staab, C. A. Lyman, L. J. Gordon, and P. Sundstrom Genome-Wide Transcriptional Profiling of the Cyclic AMP-Dependent Signaling Pathway during Morphogenic Transitions of Candida albicans Eukaryot. Cell, December 1, 2007; 6(12): 2376 - 2390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Wolyniak and P. Sundstrom Role of Actin Cytoskeletal Dynamics in Activation of the Cyclic AMP Pathway and HWP1 Gene Expression in Candida albicans Eukaryot. Cell, October 1, 2007; 6(10): 1824 - 1840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Vinces and C. A. Kumamoto The morphogenetic regulator Czf1p is a DNA-binding protein that regulates white opaque switching in Candida albicans Microbiology, September 1, 2007; 153(9): 2877 - 2884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wang and P. J. Szaniszlo WdStuAp, an APSES Transcription Factor, Is a Regulator of Yeast-Hyphal Transitions in Wangiella (Exophiala) dermatitidis Eukaryot. Cell, September 1, 2007; 6(9): 1595 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Enjalbert, D. M. MacCallum, F. C. Odds, and A. J. P. Brown Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans Infect. Immun., May 1, 2007; 75(5): 2143 - 2151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dunkler and J. Wendland Candida albicans Rho-Type GTPase-Encoding Genes Required for Polarized Cell Growth and Cell Separation Eukaryot. Cell, May 1, 2007; 6(5): 844 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Argimon, J. A. Wishart, R. Leng, S. Macaskill, A. Mavor, T. Alexandris, S. Nicholls, A. W. Knight, B. Enjalbert, R. Walmsley, et al. Developmental Regulation of an Adhesin Gene during Cellular Morphogenesis in the Fungal Pathogen Candida albicans Eukaryot. Cell, April 1, 2007; 6(4): 682 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kim, M. J. Wolyniak, J. F. Staab, and P. Sundstrom A 368-Base-Pair cis-Acting HWP1 Promoter Region, HCR, of Candida albicans Confers Hypha-Specific Gene Regulation and Binds Architectural Transcription Factors Nhp6 and Gcf1p Eukaryot. Cell, April 1, 2007; 6(4): 693 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Levitin, A. Marcil, G. Tettweiler, M. J. Laforest, U. Oberholzer, A. M. Alarco, D. Y. Thomas, P. Lasko, and M. Whiteway Drosophila melanogaster Thor and Response to Candida albicans Infection Eukaryot. Cell, April 1, 2007; 6(4): 658 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Alvarez and J. B. Konopka Identification of an N-Acetylglucosamine Transporter That Mediates Hyphal Induction in Candida albicans Mol. Biol. Cell, March 1, 2007; 18(3): 965 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Court and P. Sudbery Regulation of Cdc42 GTPase Activity in the Formation of Hyphae in Candida albicans Mol. Biol. Cell, January 1, 2007; 18(1): 265 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen and C. A. Kumamoto A conserved G protein (Drg1p) plays a role in regulation of invasive filamentation in Candida albicans Microbiology, December 1, 2006; 152(12): 3691 - 3700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Mulhern, M. E. Logue, and G. Butler Candida albicans Transcription Factor Ace2 Regulates Metabolism and Is Required for Filamentation in Hypoxic Conditions Eukaryot. Cell, December 1, 2006; 5(12): 2001 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Naglik, F. Fostira, J. Ruprai, J. F. Staab, S. J. Challacombe, and P. Sundstrom Candida albicans HWP1 gene expression and host antibody responses in colonization and disease. J. Med. Microbiol., October 1, 2006; 55(Pt 10): 1323 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C.G. Rida, A. Nishikawa, G. Y. Won, and N. Dean Yeast-to-Hyphal Transition Triggers Formin-dependent Golgi Localization to the Growing Tip in Candida albicans Mol. Biol. Cell, October 1, 2006; 17(10): 4364 - 4378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Oberholzer, A. Nantel, J. Berman, and M. Whiteway Transcript Profiles of Candida albicans Cortical Actin Patch Mutants Reflect Their Cellular Defects: Contribution of the Hog1p and Mkc1p Signaling Pathways. Eukaryot. Cell, August 1, 2006; 5(8): 1252 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dignard and M. Whiteway SST2, a Regulator of G-Protein Signaling for the Candida albicans Mating Response Pathway Eukaryot. Cell, January 1, 2006; 5(1): 192 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cao, S. Lane, P. P. Raniga, Y. Lu, Z. Zhou, K. Ramon, J. Chen, and H. Liu The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans Mol. Biol. Cell, January 1, 2006; 17(1): 295 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sohn, M. Roehm, C. Urban, N. Saunders, D. Rothenstein, F. Lottspeich, K. Schroppel, H. Brunner, and S. Rupp Identification and Characterization of Cor33p, a Novel Protein Implicated in Tolerance towards Oxidative Stress in Candida albicans Eukaryot. Cell, December 1, 2005; 4(12): 2160 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tournu, G. Tripathi, G. Bertram, S. Macaskill, A. Mavor, L. Walker, F. C. Odds, N. A. R. Gow, and A. J. P. Brown Global Role of the Protein Kinase Gcn2 in the Human Pathogen Candida albicans Eukaryot. Cell, October 1, 2005; 4(10): 1687 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Martin, A. Walther, and J. Wendland Ras1-Induced Hyphal Development in Candida albicans Requires the Formin Bni1 Eukaryot. Cell, October 1, 2005; 4(10): 1712 - 1724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Hromatka, S. M. Noble, and A. D. Johnson Transcriptional Response of Candida albicans to Nitric Oxide and the Role of the YHB1 Gene in Nitrosative Stress and Virulence Mol. Biol. Cell, October 1, 2005; 16(10): 4814 - 4826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Richard, C. J. Nobile, V. M. Bruno, and A. P. Mitchell Candida albicans Biofilm-Defective Mutants Eukaryot. Cell, August 1, 2005; 4(8): 1493 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Enjalbert and M. Whiteway Release from Quorum-Sensing Molecules Triggers Hyphal Formation during Candida albicans Resumption of Growth Eukaryot. Cell, July 1, 2005; 4(7): 1203 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kadosh and A. D. Johnson Induction of the Candida albicans Filamentous Growth Program by Relief of Transcriptional Repression: A Genome-wide Analysis Mol. Biol. Cell, June 1, 2005; 16(6): 2903 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Granger, M. L. Flenniken, D. A. Davis, A. P. Mitchell, and J. E. Cutler Yeast wall protein 1 of Candida albicans Microbiology, May 1, 2005; 151(5): 1631 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bassilana, J. Hopkins, and R. A. Arkowitz Regulation of the Cdc42/Cdc24 GTPase Module during Candida albicans Hyphal Growth Eukaryot. Cell, March 1, 2005; 4(3): 588 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Noble and A. D. Johnson Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen Candida albicans Eukaryot. Cell, February 1, 2005; 4(2): 298 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bachewich and M. Whiteway Cyclin Cln3p Links G1 Progression to Hyphal and Pseudohyphal Development in Candida albicans Eukaryot. Cell, January 1, 2005; 4(1): 95 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Schade, G. Jansen, M. Whiteway, K. D. Entian, and D. Y. Thomas Cold Adaptation in Budding Yeast Mol. Biol. Cell, December 1, 2004; 15(12): 5492 - 5502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Lorenz, J. A. Bender, and G. R. Fink Transcriptional Response of Candida albicans upon Internalization by Macrophages Eukaryot. Cell, October 1, 2004; 3(5): 1076 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nicholls, M. Straffon, B. Enjalbert, A. Nantel, S. Macaskill, M. Whiteway, and A. J. P. Brown Msn2- and Msn4-Like Transcription Factors Play No Obvious Roles in the Stress Responses of the Fungal Pathogen Candida albicans Eukaryot. Cell, October 1, 2004; 3(5): 1111 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Oberholzer, T. L. Iouk, D. Y. Thomas, and M. Whiteway Functional Characterization of Myosin I Tail Regions in Candida albicans Eukaryot. Cell, October 1, 2004; 3(5): 1272 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Harcus, A. Nantel, A. Marcil, T. Rigby, and M. Whiteway Transcription Profiling of Cyclic AMP Signaling in Candida albicans Mol. Biol. Cell, October 1, 2004; 15(10): 4490 - 4499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. K. Gordon and C. W. Sensen Osprey: a comprehensive tool employing novel methods for the design of oligonucleotides for DNA sequencing and microarrays Nucleic Acids Res., September 29, 2004; 32(17): e133 - e133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Hudson, Q. L. Sciascia, R. J. Sanders, G. E. Norris, P. J. B. Edwards, P. A. Sullivan, and P. C. Farley Identification of the dialysable serum inducer of germ-tube formation in Candida albicans Microbiology, September 1, 2004; 150(9): 3041 - 3049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. J. de Groot, A. D. de Boer, J. Cunningham, H. L. Dekker, L. de Jong, K. J. Hellingwerf, C. de Koster, and F. M. Klis Proteomic Analysis of Candida albicans Cell Walls Reveals Covalently Bound Carbohydrate-Active Enzymes and Adhesins Eukaryot. Cell, August 1, 2004; 3(4): 955 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Doedt, S. Krishnamurthy, D. P. Bockmuhl, B. Tebarth, C. Stempel, C. L. Russell, A. J.P. Brown, and J. F. Ernst APSES Proteins Regulate Morphogenesis and Metabolism in Candida albicans Mol. Biol. Cell, July 1, 2004; 15(7): 3167 - 3180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krishnamurthy, A. Plaine, J. Albert, T. Prasad, R. Prasad, and J. F. Ernst Dosage-dependent functions of fatty acid desaturase Ole1p in growth and morphogenesis of Candida albicans Microbiology, June 1, 2004; 150(6): 1991 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Martin and J. B. Konopka Lipid Raft Polarization Contributes to Hyphal Growth in Candida albicans Eukaryot. Cell, June 1, 2004; 3(3): 675 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, M. Fujita, Q. Feng, J. Clardy, and G. R. Fink Tyrosol is a quorum-sensing molecule in Candida albicans PNAS, April 6, 2004; 101(14): 5048 - 5052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Garcia-Sanchez, S. Aubert, I. Iraqui, G. Janbon, J.-M. Ghigo, and C. d'Enfert Candida albicans Biofilms: a Developmental State Associated With Specific and Stable Gene Expression Patterns Eukaryot. Cell, April 1, 2004; 3(2): 536 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Martchenko, A.-M. Alarco, D. Harcus, and M. Whiteway Superoxide Dismutases in Candida albicans: Transcriptional Regulation and Functional Characterization of the Hyphal-induced SOD5 Gene Mol. Biol. Cell, February 1, 2004; 15(2): 456 - 467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Li and S. P. Palecek EAP1, a Candida albicans Gene Involved in Binding Human Epithelial Cells Eukaryot. Cell, December 1, 2003; 2(6): 1266 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Bennett, M. A. Uhl, M. G. Miller, and A. D. Johnson Identification and Characterization of a Candida albicans Mating Pheromone Mol. Cell. Biol., November 15, 2003; 23(22): 8189 - 8201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Naglik, S. J. Challacombe, and B. Hube Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis Microbiol. Mol. Biol. Rev., September 1, 2003; 67(3): 400 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Magee, C. Gale, J. Berman, and D. Davis Molecular Genetic and Genomic Approaches to the Study of Medically Important Fungi Infect. Immun., May 1, 2003; 71(5): 2299 - 2309. [Full Text] [PDF]
|
|
|
|
|
|
C. Bachewich, D. Y. Thomas, and M. Whiteway Depletion of a Polo-like Kinase in Candida albicans Activates Cyclase-dependent Hyphal-like Growth Mol. Biol. Cell, May 1, 2003; 14(5): 2163 - 2180. [Abstract] [Full Text] [PDF]
|
|
