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Vol. 13, Issue 12, 4279-4295, December 2002
*Departments of Surgery and Orthopedics, Regenerative
Bioengineering and Repair Laboratory, UCLA School of Medicine, Los
Angeles, California 90095; and Much of the work conducted on adult stem cells has focused
on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within
the adipose stromal compartment. This cell population, termed processed
lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and,
like MSCs, differentiate toward the osteogenic, adipogenic, myogenic,
and chondrogenic lineages. To confirm whether adipose tissue contains
stem cells, the PLA population and multiple clonal isolates were
analyzed using several molecular and biochemical approaches. PLA cells
expressed multiple CD marker antigens similar to those observed on
MSCs. Mesodermal lineage induction of PLA cells and clones resulted in
the expression of multiple lineage-specific genes and proteins.
Furthermore, biochemical analysis also confirmed lineage-specific
activity. In addition to mesodermal capacity, PLA cells and clones
differentiated into putative neurogenic cells, exhibiting a
neuronal-like morphology and expressing several proteins consistent
with the neuronal phenotype. Finally, PLA cells exhibited unique
characteristics distinct from those seen in MSCs, including differences
in CD marker profile and gene expression.
Department of Medicine
and the Jonsson Comprehensive Cancer Center, Division of Hematology and
Oncology, UCLA School of Medicine, Los Angeles, California 90095
Online version of this article contains supplemental figures and
tables. Online version is available at www.molbiolcell.org.
Corresponding author. E-mail address:
zukpat{at}yahoo.com.
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C.E. Gargett Uterine stem cells: What is the evidence? Hum. Reprod. Update, January 1, 2007; 13(1): 87 - 101. [Abstract] [Full Text] [PDF]
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Q. He, C. Wan, and G. Li Concise Review: Multipotent Mesenchymal Stromal Cells in Blood Stem Cells, January 1, 2007; 25(1): 69 - 77. [Abstract] [Full Text] [PDF]
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 M. E. Trujillo and P. E. Scherer Adipose Tissue-Derived Factors: Impact on Health and Disease Endocr. Rev., December 1, 2006; 27(7): 762 - 778. [Abstract] [Full Text] [PDF]
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C. Rink, S. Roy, S. Khanna, T. Rink, D. Bagchi, and C. K. Sen Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium Physiol Genomics, November 21, 2006; 27(3): 370 - 379. [Abstract] [Full Text] [PDF]
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 K. H. Wu, Y. L. Liu, B. Zhou, and Z. C. Han Cellular therapy and myocardial tissue engineering: the role of adult stem and progenitor cells Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 770 - 781. [Abstract] [Full Text] [PDF]
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 J.J. Mao, W.V. Giannobile, J.A. Helms, S.J. Hollister, P.H. Krebsbach, M.T. Longaker, and S. Shi Craniofacial Tissue Engineering by Stem Cells Journal of Dental Research, November 1, 2006; 85(11): 966 - 979. [Abstract] [Full Text] [PDF]
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L.-E. Zaragosi, G. Ailhaud, and C. Dani Autocrine Fibroblast Growth Factor 2 Signaling Is Critical for Self-Renewal of Human Multipotent Adipose-Derived Stem Cells Stem Cells, November 1, 2006; 24(11): 2412 - 2419. [Abstract] [Full Text] [PDF]
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R. Yanez, M. L. Lamana, J. Garcia-Castro, I. Colmenero, M. Ramirez, and J. A. Bueren Adipose Tissue-Derived Mesenchymal Stem Cells Have In Vivo Immunosuppressive Properties Applicable for the Control of the Graft-Versus-Host Disease Stem Cells, November 1, 2006; 24(11): 2582 - 2591. [Abstract] [Full Text] [PDF]
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G. S. Tjabringa, P. S. Vezeridis, B. Zandieh-Doulabi, M. N. Helder, P. I.J.M. Wuisman, and J. Klein-Nulend Polyamines Modulate Nitric Oxide Production and Cox-2 Gene Expression in Response to Mechanical Loading in Human Adipose Tissue-Derived Mesenchymal Stem Cells Stem Cells, October 1, 2006; 24(10): 2262 - 2269. [Abstract] [Full Text] [PDF]
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 D. C. Wan, Y.-Y. Shi, R. P. Nacamuli, N. Quarto, K. M. Lyons, and M. T. Longaker Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling PNAS, August 15, 2006; 103(33): 12335 - 12340. [Abstract] [Full Text] [PDF]
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L. V. Rodriguez, Z. Alfonso, R. Zhang, J. Leung, B. Wu, and L. J. Ignarro Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells PNAS, August 8, 2006; 103(32): 12167 - 12172. [Abstract] [Full Text] [PDF]
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X. Wang, F. Li, and C. Niyibizi Progenitors Systemically Transplanted into Neonatal Mice Localize to Areas of Active Bone Formation In Vivo: Implications of Cell Therapy for Skeletal Diseases Stem Cells, August 1, 2006; 24(8): 1869 - 1878. [Abstract] [Full Text] [PDF]
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J. Chan, K. O'Donoghue, M. Gavina, Y. Torrente, N. Kennea, H. Mehmet, H. Stewart, D. J. Watt, J. E. Morgan, and N. M. Fisk Galectin-1 Induces Skeletal Muscle Differentiation in Human Fetal Mesenchymal Stem Cells and Increases Muscle Regeneration Stem Cells, August 1, 2006; 24(8): 1879 - 1891. [Abstract] [Full Text] [PDF]
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C.-C. Chien, B. L. Yen, F.-K. Lee, T.-H. Lai, Y.-C. Chen, S.-H. Chan, and H.-I Huang In Vitro Differentiation of Human Placenta-Derived Multipotent Cells into Hepatocyte-Like Cells Stem Cells, July 1, 2006; 24(7): 1759 - 1768. [Abstract] [Full Text] [PDF]
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R. Sarig, Z. Baruchi, O. Fuchs, U. Nudel, and D. Yaffe Regeneration and Transdifferentiation Potential of Muscle-Derived Stem Cells Propagated as Myospheres Stem Cells, July 1, 2006; 24(7): 1769 - 1778. [Abstract] [Full Text] [PDF]
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H. Aslan, Y. Zilberman, L. Kandel, M. Liebergall, R. J. Oskouian, D. Gazit, and Z. Gazit Osteogenic Differentiation of Noncultured Immunoisolated Bone Marrow-Derived CD105+ Cells Stem Cells, July 1, 2006; 24(7): 1728 - 1737. [Abstract] [Full Text] [PDF]
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S. Kern, H. Eichler, J. Stoeve, H. Kluter, and K. Bieback Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue Stem Cells, May 1, 2006; 24(5): 1294 - 1301. [Abstract] [Full Text] [PDF]
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K. McIntosh, S. Zvonic, S. Garrett, J. B. Mitchell, Z. E. Floyd, L. Hammill, A. Kloster, Y. Di Halvorsen, J. P. Ting, R. W. Storms, et al. The Immunogenicity of Human Adipose-Derived Cells: Temporal Changes In Vitro Stem Cells, May 1, 2006; 24(5): 1246 - 1253. [Abstract] [Full Text] [PDF]
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 I. Pountos, E. Jones, C. Tzioupis, D. McGonagle, and P. V. Giannoudis Growing bone and cartilage: THE ROLE OF MESENCHYMAL STEM CELLS J Bone Joint Surg Br, April 1, 2006; 88-B(4): 421 - 426. [Full Text] [PDF]
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 P. Malladi, Y. Xu, M. Chiou, A. J. Giaccia, and M. T. Longaker Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1139 - C1146. [Abstract] [Full Text] [PDF]
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J. B. Mitchell, K. McIntosh, S. Zvonic, S. Garrett, Z. E. Floyd, A. Kloster, Y. Di Halvorsen, R. W. Storms, B. Goh, G. Kilroy, et al. Immunophenotype of Human Adipose-Derived Cells: Temporal Changes in Stromal-Associated and Stem Cell-Associated Markers Stem Cells, February 1, 2006; 24(2): 376 - 385. [Abstract] [Full Text] [PDF]
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S. Y. Lee, M. Miwa, Y. Sakai, R. Kuroda, T. Niikura, and M. Kurosaka Osteogenic potential of cells in vitro derived from haemarthrosis of the knee induced by injury to the anterior cruciate ligament J Bone Joint Surg Br, January 1, 2006; 88-B(1): 129 - 133. [Abstract] [Full Text] [PDF]
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I. Dimarakis, N. A. Habib, and M. Y.A. Gordon Adult bone marrow-derived stem cells and the injured heart: just the beginning? Eur. J. Cardiothorac. Surg., November 1, 2005; 28(5): 665 - 676. [Abstract] [Full Text] [PDF]
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 V. Kindler Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions? J. Leukoc. Biol., October 1, 2005; 78(4): 836 - 844. [Abstract] [Full Text] [PDF]
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D. T.-b. Shih, D.-C. Lee, S.-C. Chen, R.-Y. Tsai, C.-T. Huang, C.-C. Tsai, E.-Y. Shen, and W.-T. Chiu Isolation and Characterization of Neurogenic Mesenchymal Stem Cells in Human Scalp Tissue Stem Cells, August 1, 2005; 23(7): 1012 - 1020. [Abstract] [Full Text] [PDF]
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 J. P. DeLany, Z. E. Floyd, S. Zvonic, A. Smith, A. Gravois, E. Reiners, X. Wu, G. Kilroy, M. Lefevre, and J. M. Gimble Proteomic Analysis of Primary Cultures of Human Adipose-derived Stem Cells: Modulation by Adipogenesis Mol. Cell. Proteomics, June 1, 2005; 4(6): 731 - 740. [Abstract] [Full Text] [PDF]
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 A.-M. Rodriguez, D. Pisani, C. A. Dechesne, C. Turc-Carel, J.-Y. Kurzenne, B. Wdziekonski, A. Villageois, C. Bagnis, J.-P. Breittmayer, H. Groux, et al. Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse J. Exp. Med., May 2, 2005; 201(9): 1397 - 1405. [Abstract] [Full Text] [PDF]
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A. J. Katz, A. Tholpady, S. S. Tholpady, H. Shang, and R. C. Ogle Cell Surface and Transcriptional Characterization of Human Adipose-Derived Adherent Stromal (hADAS) Cells Stem Cells, March 1, 2005; 23(3): 412 - 423. [Abstract] [Full Text] [PDF]
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A. C. Boquest, A. Shahdadfar, K. Fronsdal, O. Sigurjonsson, S. H. Tunheim, P. Collas, and J. E. Brinchmann Isolation and Transcription Profiling of Purified Uncultured Human Stromal Stem Cells: Alteration of Gene Expression after In Vitro Cell Culture Mol. Biol. Cell, March 1, 2005; 16(3): 1131 - 1141. [Abstract] [Full Text] [PDF]
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