Molecular Biology of the Cell Sign up for new MBC in Press e-TOCs!

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Originally published as MBC in Press, 10.1091/mbc.E02-05-0280 on September 24, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
E02-05-0280v1
13/12/4317    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, T.
Right arrow Articles by Hong, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, T.
Right arrow Articles by Hong, W.

Vol. 13, Issue 12, 4317-4332, December 2002

Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein

Tuanlao Wang, and Wanjin Hong*

Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore

We present evidence to suggest the existence of a regulatory pathway for the Golgi apparatus to modulate the spatial positioning of otherwise distantly located lysosomes. Rab34, a new member of the Rab GTPase family, is associated primarily with the Golgi apparatus. Expression of wild-type or GTP-restricted but not GDP-restricted versions of Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. The regulation of lysosomal positioning by Rab34 depends on its association with the membrane mediated by prenylation and its direct interaction with Rab-interacting lysosomal protein (RILP). This biological activity, mediated by Rab34-RILP interaction, is dependent on Lys82 in the switch I region. Our results have uncovered a novel mechanism for the Golgi apparatus to regulate the spatial distribution of another organelle.

* Corresponding author. E-mail address: mcbhwj{at}imcb.nus.edu.sg.

Molecular Biology of the Cell
Vol. 13, 4317-4332, December 2002
Copyright © 2002 by The American Society for Cell Biology


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. R. Spinosa, C. Progida, A. De Luca, A. M. R. Colucci, P. Alifano, and C. Bucci
Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease
J. Neurosci., February 13, 2008; 28(7): 1640 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. M. Goldenberg, S. Grinstein, and M. Silverman
Golgi-bound Rab34 Is a Novel Member of the Secretory Pathway
Mol. Biol. Cell, December 1, 2007; 18(12): 4762 - 4771.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. R. Terebiznik, C. L. Vazquez, K. Torbicki, D. Banks, T. Wang, W. Hong, S. R. Blanke, M. I. Colombo, and N. L. Jones
Helicobacter pylori VacA Toxin Promotes Bacterial Intracellular Survival in Gastric Epithelial Cells
Infect. Immun., December 1, 2006; 74(12): 6599 - 6614.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Buvelot Frei, P. B. Rahl, M. Nussbaum, B. J. Briggs, M. Calero, S. Janeczko, A. D. Regan, C. Z. Chen, Y. Barral, G. R. Whittaker, et al.
Bioinformatic and comparative localization of rab proteins reveals functional insights into the uncharacterized GTPases ypt10p and ypt11p.
Mol. Cell. Biol., October 1, 2006; 26(19): 7299 - 7317.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
L. A. Knodler and O. Steele-Mortimer
The Salmonella Effector PipB2 Affects Late Endosome/Lysosome Distribution to Mediate Sif Extension
Mol. Biol. Cell, September 1, 2005; 16(9): 4108 - 4123.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. R. Junutula, A. M. De Maziere, A. A. Peden, K. E. Ervin, R. J. Advani, S. M. van Dijk, J. Klumperman, and R. H. Scheller
Rab14 Is Involved in Membrane Trafficking between the Golgi Complex and Endosomes
Mol. Biol. Cell, May 1, 2004; 15(5): 2218 - 2229.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. Wang, K. K. Wong, and W. Hong
A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34
Mol. Biol. Cell, February 1, 2004; 15(2): 815 - 826.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]