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Vol. 13, Issue 2, 435-444, February 2002
Department of Zoology, University of Oxford, Oxford, OX1 3PS United
Kingdom
A critical event in eukaryotic DNA replication involves association
of minichromosome maintenance (MCM2-7) proteins with origins, to form
prereplicative complexes (pre-RCs) that are competent for initiation.
The ability of mutants defective in MCM2-7 function to complete
meiosis had suggested that pre-RC components could be irrelevant to
premeiotic S phase. We show here that MCM2-7 proteins bind to
chromatin in fission yeast cells preparing for meiosis and during
premeiotic S phase in a manner suggesting they in fact are required for
DNA replication in the meiotic cycle. This is confirmed by analysis of
a degron mcm4 mutant, which cannot carry out premeiotic
DNA replication. Later in meiosis, Mcm4 chromatin association is
blocked between meiotic nuclear divisions, presumably accounting for
the absence of a second round of DNA replication. Together, these
results emphasize similarity between replication mechanisms in mitotic
and meiotic cell cycles.
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