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Vol. 13, Issue 2, 503-514, February 2002
and
§
Departments of *Molecular Biophysics and Biochemistry and
Protein kinases in the Cot-1/Orb6/Ndr/Warts family are important
regulators of cell morphogenesis and proliferation. Cbk1p, a member of
this family in Saccharomyces cerevisiae, has previously been shown to be required for normal morphogenesis in vegetatively growing cells and in haploid cells responding to mating pheromone. A
mutant of PAG1, a novel gene in S.
cerevisiae, displayed defects similar to those of
cbk1 mutants. pag1 and
cbk1 mutants share a common set of suppressors,
including the disruption of SSD1, a gene encoding an RNA
binding protein, and the overexpression of Sim1p, an extracellular
protein. These genetic results suggest that PAG1 and
CBK1 act in the same pathway. Furthermore, we found that
Pag1p and Cbk1p localize to the same polarized peripheral sites and
that they coimmunoprecipitate with each other. Pag1p is a conserved
protein. The homologs of Pag1p in other organisms are likely to form
complexes with the Cbk1p-related kinases and function with those
kinases in the same biological processes.
Cell Biology, Yale University School of Medicine, New
Haven, Connecticut 06520
Present address: Department of Molecular Biology,
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037.
§
Corresponding author. E-mail address:
peter.novick{at}yale.edu.
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