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Vol. 13, Issue 2, 593-606, February 2002
Departments of *Biology and The phylum Apicomplexa includes thousands of species of obligate
intracellular parasites, many of which are significant human and/or
animal pathogens. Parasites in this phylum replicate by assembling
daughters within the mother, using a cytoskeletal and membranous
scaffolding termed the inner membrane complex. Most apicomplexan
parasites, including Plasmodium sp. (which cause malaria), package many daughters within a single mother during mitosis,
whereas Toxoplasma gondii typically packages only two. The comparatively simple pattern of T. gondii cell
division, combined with its molecular genetic and cell biological
accessibility, makes this an ideal system to study parasite cell
division. A recombinant fusion between the fluorescent protein reporter
YFP and the inner membrane complex protein IMC1 has been exploited to
examine daughter scaffold formation in T. gondii.
Time-lapse video microscopy permits the entire cell cycle of these
parasites to be visualized in vivo. In addition to replication via
endodyogeny (packaging two parasites at a time), T.
gondii is also capable of forming multiple daughters,
suggesting fundamental similarities between cell division in T.
gondii and other apicomplexan parasites.
Cell and Developmental
Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104;
Division of Geographic Medicine, University of Alabama,
Birmingham, Alabama 35294; and Center for Tropical and
Emerging Global Diseases and Department of Cellular Biology, University
of Georgia, Athens, Georgia 30602
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