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Vol. 13, Issue 3, 847-853, March 2002
Institut für Physiologische Chemie der Universität
München, D-81377 München, Germany
The understanding of the processes underlying organellar function
and inheritance requires the identification and characterization of the
molecular components involved. We pursued a genomic approach to define
the complements of genes required for respiratory growth and
inheritance of mitochondria with normal morphology in yeast. With the
systematic screening of a deletion mutant library covering the
nonessential genes of Saccharomyces cerevisiae the
numbers of genes known to be required for respiratory function and
establishment of wild-type-like mitochondrial structure have been more
than doubled. In addition to the identification of novel components, the systematic screen revealed unprecedented mitochondrial phenotypes that have never been observed by conventional screens. These data provide a comprehensive picture of the cellular processes and molecular
components required for mitochondrial function and structure in a
simple eukaryotic cell.
Corresponding author. E-mail address:
benedikt.westermann{at}bio.med.uni-muenchen.de.
*
The first five authors contributed equally to this work and are
listed in alphabetical order.
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