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Vol. 13, Issue 3, 892-901, March 2002
*Department of Cell Biology, The Johns Hopkins University School of
Medicine, Baltimore, Maryland 21205; Mutations in the Caenorhabditis elegans unc-84 gene
cause defects in nuclear migration and anchoring. We show that
endogenous UNC-84 protein colocalizes with Ce-lamin at the nuclear
envelope and that the envelope localization of UNC-84 requires
Ce-lamin. We also show that during mitosis, UNC-84 remains at the
nuclear periphery until late anaphase, similar to known inner nuclear membrane proteins. UNC-84 protein is first detected at the 26-cell stage and thereafter is present in most cells during development and in
adults. UNC-84 is properly expressed in unc-83 and
anc-1 lines, which have phenotypes similar to
unc-84, suggesting that neither the expression nor
nuclear envelope localization of UNC-84 depends on UNC-83 or ANC-1
proteins. The envelope localization of Ce-lamin, Ce-emerin, Ce-MAN1,
and nucleoporins are unaffected by the loss of UNC-84. UNC-84 is not
required for centrosome attachment to the nucleus because centrosomes
are localized normally in unc-84 hyp7 cells despite a
nuclear migration defect. Models for UNC-84 localization are discussed.
Howard Hughes
Medical Institute and Department of MCD Biology, The University of
Colorado, Boulder, Colorado 80309; §Department of
Genetics, The Institute of Life Sciences, The Hebrew University of
Jerusalem, Jerusalem, 91904 Israel; and Department of
Embryology, Carnegie Institute of Washington, Baltimore, Maryland 21210
Both authors contributed equally to this work.
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