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Vol. 13, Issue 5, 1641-1651, May 2002
Howard Hughes Medical Institute and Division of Biology,
California Institute of Technology, Pasadena, California 91125
Ovulation in Caenorhabditis elegans requires
inositol 1,4,5-triphosphate (IP3) signaling
activated by the epidermal growth factor (EGF)-receptor homolog LET-23.
We generated a deletion mutant of a type I 5-phosphatase,
ipp-5, and found a novel ovulation phenotype whereby the
spermatheca hyperextends to engulf two oocytes per ovulation cycle. The
temporal and spatial expression of IPP-5 is consistent with its
proposed inhibition of IP3 signaling in the adult
spermatheca. ipp-5 acts downstream of
let-23, and interacts with
let-23-mediated IP3 signaling pathway
genes. We infer that IPP-5 negatively regulates IP3
signaling to ensure proper spermathecal contraction.
Online version of this article contains video material. Online
version available at www.molbiolcell.org.
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