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Vol. 13, Issue 5, 1750-1764, May 2002
and
*Institute for Molecular Bioscience, Center for Microscopy and
Microanalysis, and Department of Physiology and Pharmacology, School of
Biomedical Sciences, University of Queensland, Queensland 4072, Australia; and Simian virus 40 (SV40) is a nonenveloped virus that has been shown
to pass from surface caveolae to the endoplasmic reticulum in an
apparently novel infectious entry pathway. We now show that the
initial entry step is blocked by brefeldin A and by incubation at
20°C. Subsequent to the entry step, the virus reaches a domain of the
rough endoplasmic reticulum by an unknown pathway. This intracellular
trafficking pathway is also brefeldin A sensitive. Infection is
strongly inhibited by expression of GTP-restricted ADP-ribosylation
factor 1 (Arf1) and Sar1 mutants and by microinjection of antibodies to
European Molecular Biology Laboratory,
69117 Heidelberg, Germany
COP. In addition, we demonstrate a potent inhibition of SV40
infection by the dipeptide
N-benzoyl-oxycarbonyl-Gly-Phe-amide, which also inhibits
late events in cholera toxin action. Our results identify novel
inhibitors of SV40 infection and show that SV40 requires COPI- and
COPII-dependent transport steps for successful infection.
Present address: Institute of Pathology,
University of Oslo, The National Hospital, 0027 Oslo, Norway.
§
Corresponding author. E-mail address:
r.parton{at}imb.uq.edu.au.
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