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Vol. 13, Issue 5, 1778-1791, May 2002
and
Departments of *Cell Biology and §Pathology, Harvard
Medical School, Boston, Massachusetts 02115; The endoplasmic reticulum (ER) is divided into rough and smooth
domains (RER and SER). The two domains share most proteins, but RER is
enriched in some membrane proteins by an unknown mechanism. We studied
RER protein targeting by expressing fluorescent protein fusions to ER
membrane proteins in Caenorhabditis elegans. In several
cell types RER and general ER proteins colocalized, but in neurons RER
proteins were concentrated in the cell body, whereas general ER
proteins were also found in neurites. Surprisingly RER membrane
proteins diffused rapidly within the cell body, indicating they are not
localized by immobilization. Ribosomes were also concentrated in the
cell body, suggesting they may be in part responsible for targeting RER
membrane proteins.
Center for
C. elegans Anatomy, Department of Neuroscience, Albert
Einstein College of Medicine, Bronx, New York 10461; and
Light Microscopy Group and Cell Biophysics Programme,
European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
Present address: Institute of Neuroscience,
University of Oregon 1254, Eugene, OR 97403.
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