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Vol. 13, Issue 6, 1916-1928, June 2002
and
*Institut de Biologie Moléculaire des Plantes du CNRS, 67084 Strasbourg, France; The SCF (for SKP1, Cullin/CDC53,
F-box protein) ubiquitin ligase targets a number of cell
cycle regulators, transcription factors, and other proteins for
degradation in yeast and mammalian cells. Recent genetic studies
demonstrate that plant F-box proteins are involved in auxin responses,
jasmonate signaling, flower morphogenesis, photocontrol of circadian
clocks, and leaf senescence, implying a large spectrum of functions for
the SCF pathway in plant development. Here, we present a molecular and
functional characterization of plant cullins. The
Arabidopsis genome contains 11 cullin-related genes.
Complementation assays revealed that AtCUL1 but not AtCUL4 can
functionally complement the yeast cdc53 mutant.
Arabidopsis mutants containing transfer DNA
(T-DNA) insertions in the AtCUL1 gene were shown
to display an arrest in early embryogenesis. Consistently, both the
transcript and the protein of the AtCUL1 gene were found to accumulate in embryos. The AtCUL1 protein localized mainly in the
nucleus but also weakly in the cytoplasm during interphase and
colocalized with the mitotic spindle in metaphase. Our results demonstrate a critical role for the SCF ubiquitin ligase in
Arabidopsis embryogenesis.
Institute for Cellular and Molecular
Biology Molecular, Cellular and Developmental Biology Section,
University of Texas at Austin, Austin, TX 78712;
Department of Biochemistry, School of Life Sciences,
Fudan University, Shanghai 200433, PR China; §INRA Colmar,
UMR Vigne et Vin Alsace, Biologie du Développement de la Vigne,
68021 Colmar, France; Laboratoire de Biologie
Cellulaire, INRA-INAPG, 78026 Versailles, France; and
¶Laboratoire de Biologie des Semences, INRA-INAPG, 78026 Versailles, France.
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