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Vol. 13, Issue 6, 1977-2000, June 2002
¶ and
*Departments of Genetics and §Biochemistry,
The genome-wide program of gene expression during the cell division
cycle in a human cancer cell line (HeLa) was characterized using cDNA
microarrays. Transcripts of >850 genes showed periodic variation
during the cell cycle. Hierarchical clustering of the expression
patterns revealed coexpressed groups of previously well-characterized
genes involved in essential cell cycle processes such as DNA
replication, chromosome segregation, and cell adhesion along with genes
of uncharacterized function. Most of the genes whose expression had
previously been reported to correlate with the proliferative state of
tumors were found herein also to be periodically expressed during the
HeLa cell cycle. However, some of the genes periodically expressed in
the HeLa cell cycle do not have a consistent correlation with tumor
proliferation. Cell cycle-regulated transcripts of genes involved in
fundamental processes such as DNA replication and chromosome
segregation seem to be more highly expressed in proliferative tumors
simply because they contain more cycling cells. The data in this report
provide a comprehensive catalog of cell cycle regulated genes that can
serve as a starting point for functional discovery. The full dataset is
available at http://genome-www.stanford.edu/Human-CellCycle/HeLa/.
Howard Hughes Medical Institute, Stanford University
School of Medicine, Stanford, California 94305;
Department of Biomedical Sciences, College of Medicine,
Florida State University, Tallahassee, Florida 32306; and
Department of Genetics, Lineberger Comprehensive Cancer
Center, University of North Carolina at Chapel Hill, Chapel Hill, North
Carolina 27599
A complete data set for this article is available
at www.molbiolcell.org. Article published online ahead of print. Mol.
Biol. Cell 10.1091/mbc.02-02-0030. Article and publication date are at www.molbiolcell.org/cgi/doi/10.1091/mbc.02-02-0030.
¶
Corresponding authors. E-mail
addresses: botstein{at}genome.stanford.edu or pbrown{at}cmgm.stanford.edu.
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