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Vol. 13, Issue 6, 1977-2000, June 2002
¶ and
*Departments of Genetics and §Biochemistry,
The genome-wide program of gene expression during the cell division
cycle in a human cancer cell line (HeLa) was characterized using cDNA
microarrays. Transcripts of >850 genes showed periodic variation
during the cell cycle. Hierarchical clustering of the expression
patterns revealed coexpressed groups of previously well-characterized
genes involved in essential cell cycle processes such as DNA
replication, chromosome segregation, and cell adhesion along with genes
of uncharacterized function. Most of the genes whose expression had
previously been reported to correlate with the proliferative state of
tumors were found herein also to be periodically expressed during the
HeLa cell cycle. However, some of the genes periodically expressed in
the HeLa cell cycle do not have a consistent correlation with tumor
proliferation. Cell cycle-regulated transcripts of genes involved in
fundamental processes such as DNA replication and chromosome
segregation seem to be more highly expressed in proliferative tumors
simply because they contain more cycling cells. The data in this report
provide a comprehensive catalog of cell cycle regulated genes that can
serve as a starting point for functional discovery. The full dataset is
available at http://genome-www.stanford.edu/Human-CellCycle/HeLa/.
Howard Hughes Medical Institute, Stanford University
School of Medicine, Stanford, California 94305;
Department of Biomedical Sciences, College of Medicine,
Florida State University, Tallahassee, Florida 32306; and
Department of Genetics, Lineberger Comprehensive Cancer
Center, University of North Carolina at Chapel Hill, Chapel Hill, North
Carolina 27599
A complete data set for this article is available
at www.molbiolcell.org. Article published online ahead of print. Mol.
Biol. Cell 10.1091/mbc.02-02-0030. Article and publication date are at www.molbiolcell.org/cgi/doi/10.1091/mbc.02-02-0030.
¶
Corresponding authors. E-mail
addresses: botstein{at}genome.stanford.edu or pbrown{at}cmgm.stanford.edu.
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M. Fahling, R. Mrowka, A. Steege, P. Martinka, P. B. Persson, and B. J. Thiele Heterogeneous Nuclear Ribonucleoprotein-A2/B1 Modulate Collagen Prolyl 4-Hydroxylase, {alpha} (I) mRNA Stability J. Biol. Chem., April 7, 2006; 281(14): 9279 - 9286. [Abstract] [Full Text] [PDF]
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A. V. Tkatchenko, P. A. Walsh, T. V. Tkatchenko, S. Gustincich, and E. Raviola Form deprivation modulates retinal neurogenesis in primate experimental myopia PNAS, March 21, 2006; 103(12): 4681 - 4686. [Abstract] [Full Text] [PDF]
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S. Schmidt, J. Rainer, S. Riml, C. Ploner, S. Jesacher, C. Achmuller, E. Presul, S. Skvortsov, R. Crazzolara, M. Fiegl, et al. Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia Blood, March 1, 2006; 107(5): 2061 - 2069. [Abstract] [Full Text] [PDF]
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P. K. Pandey, T. S. Udayakumar, X. Lin, D. Sharma, P. S. Shapiro, and J. D. Fondell Activation of TRAP/Mediator Subunit TRAP220/Med1 Is Regulated by Mitogen-Activated Protein Kinase-Dependent Phosphorylation Mol. Cell. Biol., December 15, 2005; 25(24): 10695 - 10710. [Abstract] [Full Text] [PDF]
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K. Willbrand, F. Radvanyi, J.-P. Nadal, J.-P. Thiery, and T. M. A. Fink Identifying genes from up-down properties of microarray expression series Bioinformatics, October 15, 2005; 21(20): 3859 - 3864. [Abstract] [Full Text] [PDF]
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P. A. Hall, C. B. Todd, P. L. Hyland, S. S. McDade, H. Grabsch, M. Dattani, K. J. Hillan, and S.E. H. Russell The Septin-Binding Protein Anillin Is Overexpressed in Diverse Human Tumors Clin. Cancer Res., October 1, 2005; 11(19): 6780 - 6786. [Abstract] [Full Text] [PDF]
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I. Shmulevich, S. A. Kauffman, and M. Aldana Eukaryotic cells are dynamically ordered or critical but not chaotic PNAS, September 20, 2005; 102(38): 13439 - 13444. [Abstract] [Full Text] [PDF]
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E. Balciunaite, A. Spektor, N. H. Lents, H. Cam, H. te Riele, A. Scime, M. A. Rudnicki, R. Young, and B. D. Dynlacht Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells Mol. Cell. Biol., September 15, 2005; 25(18): 8166 - 8178. [Abstract] [Full Text] [PDF]
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K. J. Palmer, J. E. Konkel, and D. J. Stephens PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport J. Cell Sci., September 1, 2005; 118(17): 3839 - 3847. [Abstract] [Full Text] [PDF]
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M. T. Bengoechea-Alonso, T. Punga, and J. Ericsson Hyperphosphorylation regulates the activity of SREBP1 during mitosis PNAS, August 16, 2005; 102(33): 11681 - 11686. [Abstract] [Full Text] [PDF]
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C.-T. R. Yu, J.-M. Hsu, Y.-C. G. Lee, A.-P. Tsou, C.-K. Chou, and C.-Y. F. Huang Phosphorylation and Stabilization of HURP by Aurora-A: Implication of HURP as a Transforming Target of Aurora-A Mol. Cell. Biol., July 15, 2005; 25(14): 5789 - 5800. [Abstract] [Full Text] [PDF]
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Y. He, M. A. Brown, J. A. Rothnagel, N. A. Saunders, and R. Smith Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation J. Cell Sci., July 15, 2005; 118(14): 3173 - 3183. [Abstract] [Full Text] [PDF]
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R. C. Osthus, B. Karim, J. E. Prescott, B. D. Smith, M. McDevitt, D. L. Huso, and C. V. Dang The Myc Target Gene JPO1/CDCA7 Is Frequently Overexpressed in Human Tumors and Has Limited Transforming Activity In vivo Cancer Res., July 1, 2005; 65(13): 5620 - 5627. [Abstract] [Full Text] [PDF]
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G. A. Boorman, P. E. Blackshear, J. S. Parker, E. K. Lobenhofer, D. E. Malarkey, M. K. Vallant, D. K. Gerken, and R. D. Irwin Hepatic Gene Expression Changes throughout the Day in the Fischer Rat: Implications for Toxicogenomic Experiments Toxicol. Sci., July 1, 2005; 86(1): 185 - 193. [Abstract] [Full Text] [PDF]
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Z. Zhu, J. Shendure, and G. M. Church Discovering functional transcription-factor combinations in the human cell cycle Genome Res., June 1, 2005; 15(6): 848 - 855. [Abstract] [Full Text] [PDF]
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H. Dai, L. van't Veer, J. Lamb, Y. D. He, M. Mao, B. M. Fine, R. Bernards, M. van de Vijver, P. Deutsch, A. Sachs, et al. A Cell Proliferation Signature Is a Marker of Extremely Poor Outcome in a Subpopulation of Breast Cancer Patients Cancer Res., May 15, 2005; 65(10): 4059 - 4066. [Abstract] [Full Text] [PDF]
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