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Vol. 13, Issue 6, 2080-2090, June 2002
and
Cell Cycle Laboratory, Imperial Cancer Research Fund, London, WC2A
3PX, United Kingdom
Cyclin-dependent kinases (CDKs) are important for both mitotic and
meiotic cell cycles. In fission yeast, the major CDK, Cdc2p is involved
in premeiotic DNA replication and in meiosis II. One of its partners,
the mitotic cyclin Cdc13p is known to be required for meiosis, whereas
there are no studies on the G1/S cyclin Cig2p. In this article, we have
studied the regulation of the Cdc2p/Cdc13p and Cdc2p/Cig2p complexes
during synchronous meiosis. We observed that Cdc2p/Cig2p kinase is
activated in an unexpected biphasic manner, first at onset of
premeiotic S phase and again during meiotic nuclear divisions. The role
of Cig2p during meiosis was investigated using
cig2-deleted strains that exhibit delays in onset of
both S phase and meiotic divisions as well as an inefficient completion
of MII. Furthermore, analysis of cig2 transcripts
revealed a meiosis-specific regulation of cig2
expression during MI/MII dependent upon the Mei4p transcription factor
leading to a different transcription start site at this stage of meiosis.
Department of Biochemistry,
Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho,
Mizuho-ku, Nagoya 467-8601, Japan;
Cell Signaling
Unit, Department de Ciències Experimentals i de la Salut,
Universitat Pompeu Fabra, C/Doctor Aiguader 80, 08003 Barcelona, Spain.
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