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Vol. 13, Issue 8, 2783-2794, August 2002
*Department of Biochemistry, Academic Medical Center, University of
Amsterdam, 1105 AZ Amsterdam, The Netherlands; Yeast cells were grown in glucose-limited chemostat cultures and
forced to switch to a new carbon source, the fatty acid oleate. Alterations in gene expression were monitored using DNA microarrays combined with bioinformatics tools, among which was included the recently developed algorithm REDUCE. Immediately after the switch to
oleate, a transient and very specific stress response was observed, followed by the up-regulation of genes encoding peroxisomal enzymes required for fatty acid metabolism. The stress response included up-regulation of genes coding for enzymes to keep thioredoxin and
glutathione reduced, as well as enzymes required for the detoxification of reactive oxygen species. Among the genes coding for various isoenzymes involved in these processes, only a specific subset was
expressed. Not the general stress transcription factors Msn2 and Msn4,
but rather the specific factor Yap1p seemed to be the main regulator of
the stress response. We ascribe the initiation of the oxidative stress
response to a combination of poor redox flux and fatty acid-induced
uncoupling of the respiratory chain during the metabolic reprogramming phase.
Department
of Plant Pathology, Swammerdam Institute for Life Sciences, University
of Amsterdam, 1098 SM Amsterdam, The Netherlands; and
§Department of Microbiology, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
Present address: Department of Biological
Sciences, Columbia University, 1212 Amsterdam Ave., MC 2441, New York,
NY 10027.
Corresponding author. E-mail address:
h.f.tabak{at}med.uu.nl.
Online version of this article contains
complete data sets. Online version available at
www.molbiolcell.org.
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