![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vol. 13, Issue 9, 3064-3077, September 2002
and
*Department of Biochemistry and Molecular Genetics, University of
Virginia Medical Center, Charlottesville, Virginia 22908; and
Aurora B regulates chromosome segregation and cytokinesis and is
the first protein to be implicated as a regulator of bipolar attachment
of spindle microtubules to kinetochores. Evidence from several systems suggests that Aurora B is physically associated with
inner centromere protein (INCENP) in mitosis and has genetic interactions with Survivin. It is unclear whether the Aurora B and
INCENP interaction is cell cycle regulated and if Survivin physically
interacts in this complex. In this study, we cloned the
Xenopus Survivin gene, examined its association with
Aurora B and INCENP, and determined the effect of its binding on Aurora B kinase activity. We demonstrate that in the Xenopus
early embryo, all of the detectable Survivin is in a complex with both
Aurora B and INCENP throughout the cell cycle. Survivin and Aurora B bind different domains on INCENP. Aurora B activity is stimulated >10-fold in mitotic extracts; this activation is phosphatase
sensitive, and the binding of Survivin is required for full Aurora B
activity. We also find the hydrodynamic properties of the Aurora
B/Survivin/INCENP complex are cell cycle regulated. Our data indicate
that Aurora B kinase activity is regulated by both Survivin binding and
cell cycle-dependent phosphorylation.
Department of Experimental Therapeutics, University of
Texas, MD Anderson Center, Houston, Texas 77908
Corresponding author. E-mail address:
pts7h{at}virginia.edu.
This article has been cited by other articles:
|
|
 |
|
  A. A. Dar, L. W. Goff, S. Majid, J. Berlin, and W. El-Rifai Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics? Mol. Cancer Ther., February 1, 2010; 9(2): 268 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xu, H. Ogawa, P. Vagnarelli, J. H. Bergmann, D. F. Hudson, S. Ruchaud, T. Fukagawa, W. C. Earnshaw, and K. Samejima INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization J. Cell Biol., November 30, 2009; 187(5): 637 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Makrantoni and M. J. R. Stark Efficient Chromosome Biorientation and the Tension Checkpoint in Saccharomyces cerevisiae both Require Bir1 Mol. Cell. Biol., August 15, 2009; 29(16): 4552 - 4562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ferri, H. Bouzinba-Segard, G. Velasco, F. Hube, and C. Francastel Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase Nucleic Acids Res., August 1, 2009; 37(15): 5071 - 5080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hans, D. A. Skoufias, S. Dimitrov, and R. L. Margolis Molecular Distinctions between Aurora A and B: A Single Residue Change Transforms Aurora A into Correctly Localized and Functional Aurora B Mol. Biol. Cell, August 1, 2009; 20(15): 3491 - 3502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fu, M. Bian, J. Liu, Q. Jiang, and C. Zhang A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function PNAS, April 28, 2009; 106(17): 6939 - 6944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yue, A. Carvalho, Z. Xu, X. Yuan, S. Cardinale, S. Ribeiro, F. Lai, H. Ogawa, E. Gudmundsdottir, R. Gassmann, et al. Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line J. Cell Biol., October 20, 2008; 183(2): 279 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Xia, P. M. Canovas, T. M. Guadagno, and D. C. Altieri A Survivin-Ran Complex Regulates Spindle Formation in Tumor Cells Mol. Cell. Biol., September 1, 2008; 28(17): 5299 - 5311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Mita, M. M. Mita, S. T. Nawrocki, and F. J. Giles Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics Clin. Cancer Res., August 15, 2008; 14(16): 5000 - 5005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Yamamoto, A. L. Lewellyn, and J. L. Maller Regulation of the Aurora B Chromosome Passenger Protein Complex during Oocyte Maturation in Xenopus laevis Mol. Cell. Biol., June 15, 2008; 28(12): 4196 - 4203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Brennan, E. Rexhepaj, S. L. O'Brien, E. McSherry, D. P. O'Connor, A. Fagan, A. C. Culhane, D. G. Higgins, K. Jirstrom, R. C. Millikan, et al. Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer Clin. Cancer Res., May 1, 2008; 14(9): 2681 - 2689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chanrion, V. Negre, H. Fontaine, N. Salvetat, F. Bibeau, G. M. Grogan, L. Mauriac, D. Katsaros, F. Molina, C. Theillet, et al. A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer Clin. Cancer Res., March 15, 2008; 14(6): 1744 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Thomas and K. B. Kaplan A Bir1p Sli15p Kinetochore Passenger Complex Regulates Septin Organization during Anaphase Mol. Biol. Cell, October 1, 2007; 18(10): 3820 - 3834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, G. S. Lakshmikanth, J. A. Spudich, and A. De Lozanne The Localization of Inner Centromeric Protein (INCENP) at the Cleavage Furrow Is Dependent on Kif12 and Involves Interactions of the N Terminus of INCENP with the Actin Cytoskeleton Mol. Biol. Cell, September 1, 2007; 18(9): 3366 - 3374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, W. Lan, S. C. Ems-McClung, P. T. Stukenberg, and C. E. Walczak Aurora B Phosphorylates Multiple Sites on Mitotic Centromere-associated Kinesin to Spatially and Temporally Regulate Its Function Mol. Biol. Cell, September 1, 2007; 18(9): 3264 - 3276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kaneko, N. Tsuji, K. Asanuma, H. Tanabe, D. Kobayashi, and N. Watanabe Survivin Down-regulation Plays a Crucial Role in 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitor-induced Apoptosis in Cancer J. Biol. Chem., July 6, 2007; 282(27): 19273 - 19281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Vogel, C. Hager, and H. Bastians Mechanisms of Mitotic Cell Death Induced by Chemotherapy-Mediated G2 Checkpoint Abrogation Cancer Res., January 1, 2007; 67(1): 339 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fu, M. Bian, Q. Jiang, and C. Zhang Roles of Aurora Kinases in Mitosis and Tumorigenesis Mol. Cancer Res., January 1, 2007; 5(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Monier, S. Mouradian, and K. F. Sullivan DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains J. Cell Sci., January 1, 2007; 120(1): 101 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vader, R. H. Medema, and S. M.A. Lens The chromosomal passenger complex: guiding Aurora-B through mitosis J. Cell Biol., June 19, 2006; 173(6): 833 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. R. Klein, E. A. Nigg, and U. Gruneberg Centromere Targeting of the Chromosomal Passenger Complex Requires a Ternary Subcomplex of Borealin, Survivin, and the N-Terminal Domain of INCENP Mol. Biol. Cell, June 1, 2006; 17(6): 2547 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rosa, P. Canovas, A. Islam, D. C. Altieri, and S. J. Doxsey Survivin Modulates Microtubule Dynamics and Nucleation throughout the Cell Cycle Mol. Biol. Cell, March 1, 2006; 17(3): 1483 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, H. Li, and A. De Lozanne Contractile Ring-independent Localization of DdINCENP, a Protein Important for Spindle Stability and Cytokinesis Mol. Biol. Cell, February 1, 2006; 17(2): 779 - 788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-I Chao and H.-F. Liu The Blockage of Survivin and Securin Expression Increases the Cytochalasin B-Induced Cell Death and Growth Inhibition in Human Cancer Cells Mol. Pharmacol., January 1, 2006; 69(1): 154 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Hanson, A. C. Kelley, and M. Bienz Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development Development, November 1, 2005; 132(21): 4777 - 4787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Huang, J. M. Bailis, J. D. Leverson, E. B. Gomez, S. L. Forsburg, and T. Hunter Suppressors of Bir1p (Survivin) Identify Roles for the Chromosomal Passenger Protein Pic1p (INCENP) and the Replication Initiation Factor Psf2p in Chromosome Segregation Mol. Cell. Biol., October 15, 2005; 25(20): 9000 - 9015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Cho, Y. Liu, M. Gomez, J. Dunlap, M. Tyers, and Y. Wang The Dual-Specificity Phosphatase CDC14B Bundles and Stabilizes Microtubules Mol. Cell. Biol., June 1, 2005; 25(11): 4541 - 4551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yan, L. Cao, Q. Li, Y. Wu, H. Zhang, H. Saiyin, X. Liu, X. Zhang, Q. Shi, and L. Yu Aurora C is directly associated with Survivin and required for cytokinesis Genes Cells, June 1, 2005; 10(6): 617 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Samuel, K. Okada, M. Hyer, K. Welsh, J. M. Zapata, and J. C. Reed cIAP1 Localizes to the Nuclear Compartment and Modulates the Cell Cycle Cancer Res., January 1, 2005; 65(1): 210 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Scrittori, D. A. Skoufias, F. Hans, V. Gerson, P. Sassone-Corsi, S. Dimitrov, and R. L. Margolis A Small C-Terminal Sequence of Aurora B Is Responsible for Localization and Function Mol. Biol. Cell, January 1, 2005; 16(1): 292 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-C. Kuo, H.-F. Liu, and J.-I Chao Survivin and p53 Modulate Quercetin-induced Cell Growth Inhibition and Apoptosis in Human Lung Carcinoma Cells J. Biol. Chem., December 31, 2004; 279(53): 55875 - 55885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Johnson and E. W. Howerth Survivin: A Bifunctional Inhibitor of Apoptosis Protein Veterinary Pathology, November 1, 2004; 41(6): 599 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Boman, R. Walters, J. Z. Fields, A. J. Kovatich, T. Zhang, G. A. Isenberg, S. D. Goldstein, and J. P. Palazzo Colonic Crypt Changes during Adenoma Development in Familial Adenomatous Polyposis: Immunohistochemical Evidence for Expansion of the Crypt Base Cell Population Am. J. Pathol., November 1, 2004; 165(5): 1489 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Beardmore, L. J. Ahonen, G. J. Gorbsky, and M. J. Kallio Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity J. Cell Sci., August 15, 2004; 117(18): 4033 - 4042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Geddis and K. Kaushansky Megakaryocytes express functional Aurora-B kinase in endomitosis Blood, August 15, 2004; 104(4): 1017 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gassmann, A. Carvalho, A. J. Henzing, S. Ruchaud, D. F. Hudson, R. Honda, E. A. Nigg, D. L. Gerloff, and W. C. Earnshaw Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle J. Cell Biol., July 19, 2004; 166(2): 179 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Gruneberg, R. Neef, R. Honda, E. A. Nigg, and F. A. Barr Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 J. Cell Biol., July 19, 2004; 166(2): 167 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ohi, T. Sapra, J. Howard, and T. J. Mitchison Differentiation of Cytoplasmic and Meiotic Spindle Assembly MCAK Functions by Aurora B-dependent Phosphorylation Mol. Biol. Cell, June 1, 2004; 15(6): 2895 - 2906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I Chao, P.-C. Kuo, and T.-S. Hsu Down-regulation of Survivin in Nitric Oxide-induced Cell Growth Inhibition and Apoptosis of the Human Lung Carcinoma Cells J. Biol. Chem., May 7, 2004; 279(19): 20267 - 20276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Asanuma, N. Tsuji, T. Endoh, A. Yagihashi, and N. Watanabe Survivin Enhances Fas Ligand Expression via Up-Regulation of Specificity Protein 1-Mediated Gene Transcription in Colon Cancer Cells J. Immunol., March 15, 2004; 172(6): 3922 - 3929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Eyers and J. L. Maller Regulation of Xenopus Aurora A Activation by TPX2 J. Biol. Chem., March 5, 2004; 279(10): 9008 - 9015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lewis, E. Burstein, S. B. Reffey, S. B. Bratton, A. B. Roberts, and C. S. Duckett Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis J. Biol. Chem., March 5, 2004; 279(10): 9023 - 9029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Wheatley, A. J. Henzing, H. Dodson, W. Khaled, and W. C. Earnshaw Aurora-B Phosphorylation in Vitro Identifies a Residue of Survivin That Is Essential for Its Localization and Binding to Inner Centromere Protein (INCENP) in Vivo J. Biol. Chem., February 13, 2004; 279(7): 5655 - 5660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Glotzer Cleavage furrow positioning J. Cell Biol., February 2, 2004; 164(3): 347 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zhang, J. Z. Fields, S. M. Ehrlich, and B. M. Boman The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma Cells J. Pharmacol. Exp. Ther., February 1, 2004; 308(2): 434 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Martinez, B. Bellosillo, F. Bosch, A. Ferrer, S. Marce, N. Villamor, G. Ott, E. Montserrat, E. Campo, and D. Colomer Nuclear Survivin Expression in Mantle Cell Lymphoma Is Associated with Cell Proliferation and Survival Am. J. Pathol., February 1, 2004; 164(2): 501 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Daidone, A. Costa, M. Frattini, D. Balestra, L. Bertario, M. A. Pierotti, B. M. Boman, T. Zhang, and J. Z. Fields Correspondence re: T. Zhang et al., Evidence That APC Regulates Survivin Expression: A Possible Mechanism Contributing to the Stem Cell Origin of Colon Cancer. Cancer Res., 61: 8664-8667, 2001. Cancer Res., January 15, 2004; 64(2): 776 - 779. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xing, E. M. Conway, C. Kang, and A. Winoto Essential Role of Survivin, an Inhibitor of Apoptosis Protein, in T Cell Development, Maturation, and Homeostasis J. Exp. Med., January 5, 2004; 199(1): 69 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Reed and D. B. Wilson Cancer Immunotherapy Targeting Survivin: Commentary re: V. Pisarev et al., Full-Length Dominant-Negative Survivin for Cancer Immunotherapy. Clin. Cancer Res., 9:6523-6533, 2003. Clin. Cancer Res., December 15, 2003; 9(17): 6310 - 6315. [Full Text] [PDF]
|
|
|
|
|
|
R. Neef, C. Preisinger, J. Sutcliffe, R. Kopajtich, E. A. Nigg, T. U. Mayer, and F. A. Barr Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis J. Cell Biol., September 1, 2003; 162(5): 863 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Honda, R. Korner, and E. A. Nigg Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis Mol. Biol. Cell, August 1, 2003; 14(8): 3325 - 3341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Song, X. Yao, and M. Wu Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis J. Biol. Chem., June 13, 2003; 278(25): 23130 - 23140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Romano, A. Guse, I. Krascenicova, H. Schnabel, R. Schnabel, and M. Glotzer CSC-1: a subunit of the aurora b kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1 J. Cell Biol., April 28, 2003; 161(2): 229 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. McCleland, R. D. Gardner, M. J. Kallio, J. R. Daum, G. J. Gorbsky, D. J. Burke, and P. T. Stukenberg The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity Genes & Dev., January 1, 2003; 17(1): 101 - 114. [Abstract] [Full Text] [PDF]
|
|
