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Vol. 13, Issue 9, 3064-3077, September 2002
and
*Department of Biochemistry and Molecular Genetics, University of
Virginia Medical Center, Charlottesville, Virginia 22908; and
Aurora B regulates chromosome segregation and cytokinesis and is
the first protein to be implicated as a regulator of bipolar attachment
of spindle microtubules to kinetochores. Evidence from several systems suggests that Aurora B is physically associated with
inner centromere protein (INCENP) in mitosis and has genetic interactions with Survivin. It is unclear whether the Aurora B and
INCENP interaction is cell cycle regulated and if Survivin physically
interacts in this complex. In this study, we cloned the
Xenopus Survivin gene, examined its association with
Aurora B and INCENP, and determined the effect of its binding on Aurora B kinase activity. We demonstrate that in the Xenopus
early embryo, all of the detectable Survivin is in a complex with both
Aurora B and INCENP throughout the cell cycle. Survivin and Aurora B bind different domains on INCENP. Aurora B activity is stimulated >10-fold in mitotic extracts; this activation is phosphatase
sensitive, and the binding of Survivin is required for full Aurora B
activity. We also find the hydrodynamic properties of the Aurora
B/Survivin/INCENP complex are cell cycle regulated. Our data indicate
that Aurora B kinase activity is regulated by both Survivin binding and
cell cycle-dependent phosphorylation.
Department of Experimental Therapeutics, University of
Texas, MD Anderson Center, Houston, Texas 77908
Corresponding author. E-mail address:
pts7h{at}virginia.edu.
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