![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vol. 13, Issue 9, 3096-3106, September 2002
Indiana University School of Medicine Department of Medicine,
Division of Nephrology, Indianapolis, Indiana 46202-5116
Nephrogenesis starts with the reciprocal induction of two
embryonically distinct analages, metanephric mesenchyme and ureteric bud. This complex process requires the refined and coordinated expression of numerous developmental genes, such as inv.
Mice that are homozygous for a mutation in the inv gene
(inv/inv) develop renal cysts resembling
autosomal-recessive polycystic kidney disease. The gene locus
containing inv has been proposed to serve as a common
modifier for some human and rodent polycystic kidney disease phenotypes. We generated polyclonal antibodies to inversin to study its
subcellular distribution, potential binding partners, and functional
aspects in cultured murine proximal tubule cells. A 125-kDa inversin
protein isoform was found at cell-cell junctions. Two inversin
isoforms, 140- and 90-kDa, were identified in the nuclear and
perinuclear compartments. Plasma membrane allocation of inversin is
dependent upon cell-cell contacts and was redistributed when cell
adhesion was disrupted after incubation of the cell monolayer with
low-calcium/EGTA medium. We further show that the membrane-associated
125-kDa inversin forms a complex with N-cadherin and the catenins. The
90-kDa nuclear inversin complexes with 
-catenin. These findings
indicate that the inv gene product functions in several
cellular compartments, including the nucleus and cell-cell adhesion sites.
This article has been cited by other articles:
|
|
 |
|
  M Adams, U M Smith, C V Logan, and C A Johnson Recent advances in the molecular pathology, cell biology and genetics of ciliopathies J. Med. Genet., May 1, 2008; 45(5): 257 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nornes, M. Newman, G. Verdile, S. Wells, C. L. Stoick-Cooper, B. Tucker, I. Frederich-Sleptsova, R. Martins, and M. Lardelli Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity Hum. Mol. Genet., February 1, 2008; 17(3): 402 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Giorgio, M. Alfieri, C. Prattichizzo, A. Zullo, S. Cairo, and B. Franco Functional Characterization of the OFD1 Protein Reveals a Nuclear Localization and Physical Interaction with Subunits of a Chromatin Remodeling Complex Mol. Biol. Cell, November 1, 2007; 18(11): 4397 - 4404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hoefele, M. T.F. Wolf, J. F. O'Toole, E. A. Otto, U. Schultheiss, G. Deschenes, M. Attanasio, B. Utsch, C. Antignac, and F. Hildebrandt Evidence of Oligogenic Inheritance in Nephronophthisis J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2789 - 2795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hildebrandt and W. Zhou Nephronophthisis-Associated Ciliopathies J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1855 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Benzing, M. Simons, and G. Walz Wnt Signaling in Polycystic Kidney Disease J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1389 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W. Bisgrove and H. J. Yost The roles of cilia in developmental disorders and disease Development, November 1, 2006; 133(21): 4131 - 4143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shiratori and H. Hamada The left-right axis in the mouse: from origin to morphology Development, June 1, 2006; 133(11): 2095 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Louie and J. G. Gleeson Genetic basis of Joubert syndrome and related disorders of cerebellar development Hum. Mol. Genet., October 15, 2005; 14(suppl_2): R235 - R242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mrug, R. Li, X. Cui, T. R. Schoeb, G. A. Churchill, and L. M. Guay-Woodford Kinesin Family Member 12 Is a Candidate Polycystic Kidney Disease Modifier in the cpk Mouse J. Am. Soc. Nephrol., April 1, 2005; 16(4): 905 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Essner, J. D. Amack, M. K. Nyholm, E. B. Harris, and H. J. Yost Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut Development, March 15, 2005; 132(6): 1247 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nurnberger, A. Kribben, A. O. Saez, G. Heusch, T. Philipp, and C. L. Phillips The Invs Gene Encodes a Microtubule-Associated Protein J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1700 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Phillips, K. J. Miller, A. J. Filson, J. Nurnberger, J. L. Clendenon, G. W. Cook, K. W. Dunn, P. A. Overbeek, V. H. Gattone II, and R. L. Bacallao Renal Cysts of inv/inv Mice Resemble Early Infantile Nephronophthisis J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1744 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. Cantiello Regulation of calcium signaling by polycystin-2 Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1012 - F1029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Guay-Woodford Murine models of polycystic kidney disease: molecular and therapeutic insights Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1034 - F1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Watanabe, Y. Saijoh, S. Nonaka, G. Sasaki, Y. Ikawa, T. Yokoyama, and H. Hamada The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia Development, May 1, 2003; 130(9): 1725 - 1734. [Abstract] [Full Text] [PDF]
|
|
